Protein Alignment Ir21a and Gria4

DIOPT Version :10

• Sequence 1: NP_001097043.1
• Gene: Ir21a / 33157
• FlyBaseID: FBgn0031209
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: NP_058959.2
• Gene: Gria4 / 29629
• RGDID: 61863
• Length: 902
• Species: Rattus norvegicus
• Alignment Length: 753
• Identity: 140/753 - (18%)
• Similarity: 265/753 - (35%)
• Gaps: 224/753 - (29%)

  Fly    84 FHVNSYNFEQTNSLVGLVNKIAQ-EYL-NKCPP----VIYYDSFV-----------EKSD----- 126
            |.:..:|......|:....|:.| ||. ::.||    .:.||..:           :|.|
  Rat   262 FQLVDFNTPMVTKLMDRWKKLDQREYPGSETPPKYTSALTYDGVLVMAETFRSLRRQKIDISRRG 326

  Fly   127 ---------------GLILENLFKTIPITFYHGEINADYEAKNKRFTSHIDCNCKSYILFLSDPL 176
                           |:.:|...|.:.|....|.:..|:..:...:|..:      :.|..:.|
  Rat   327 NAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMDV------FELKSTGP- 384

  Fly   177 MTRKILGPQTESRVVLVSRSTQWRLRDF--LSSELSSNIVNLLVIGESLMADPMRERPYVLY--T 237
              ||:.......::||:        :|.  |.::.:: |.|..|:..::|     |.|||:|  .
  Rat   385 --RKVGYWNDMDKLVLI--------QDMPTLGNDTAA-IENRTVVVTTIM-----ESPYVMYKKN 433

  Fly   238 HKLYADGLGSNTPVVLTSWIKGALSRPHINLFPSKFQFGFAGHRFQISAANQPPFIFRIRTLDSS 302
            |:::.
  Rat   434 HEMFE------------------------------------------------------------ 438

  Fly   303 GMGQLRWDGVEFRLLTMISKRLNFSIDITETP-----TRSNTRGVVDTIQEQIIERTVDIGMSGI 362
              |..:::|....|.:.|:|.:.....|...|     .|.....:.:.:..:::....:|.::.:
  Rat   439 --GNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPL 501

  Fly   363 YIT--QERLMDSA---MSVGHSPDCAAFITLASKALPKYRAIMGPFQWPVWVALICVYLGGIFPI 422
            .||  :|.::|.:   ||:|.|    ..|....|:.|...:.:.|..:.:|:.::..|: |:..:
  Rat   502 TITLVREEVIDFSKPFMSLGIS----IMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYI-GVSVV 561

  Fly   423 VFTDRLTLSHLMGNWGEVENMFWYV-----------------FGMFTNAFSFTGKYSWS----NT 466
            :|        |:..:...|   |:.                 ||:|.:.:...|.:...    :.
  Rat   562 LF--------LVSRFSPYE---WHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISP 615

  Fly   467 RKNSTRLLIGAYWLFTIIITSCYTGSIIAFVTLPAFPDTVDSVLDLL-GLFFRVGTLNNGGWETW 530
            |..|.|::.|.:|.||:||.|.||.::.||:|:......::|..||. ......|||::|..:.:
  Rat   616 RSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEF 680

  Fly   531 FQNSTHIPTSRLYKKM----------EFVGSVDEGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFS 585
            |:.|    ...:|:||          .|..:..||:..|.:| ...:|||......||:.|....
  Rat   681 FRRS----KIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKS-KGKFAFLLESTMNEYIEQRKPC 740

  Fly   586 DE-----NISRRSALHLSEECFALFQIGFLFPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVM 645
            |.     |:..:.             .|...|:.|..:..::..:|...::|::.|:.|:  |..
  Rat   741 DTMKVGGNLDSKG-------------YGVATPKGSSLRTPVNLAVLKLSEAGVLDKLKNK--WWY 790

  Fly   646 QRSSSGRLLQASSSNSLREIIQEERQLTTADTEGMFLLMALGYFLGATALVSEIVGGITNKCRQI 710
            .:...|.....|...:        ..|:.::..|:|.::..|  ||...||:.|  ....|.|..
  Rat   791 DKGECGPKDSGSKDKT--------SALSLSNVAGVFYILVGG--LGLAMLVALI--EFCYKSRAE 843

  Fly   711 IKRSR---KSAASSWSSASSGSMLRTNAEQLSHDKRKA 745
            .||.:   ..|..:.:..|....:..|...|:.|..||
  Rat   844 AKRMKLTFSEAIRNKARLSITGSVGENGRVLTPDCPKA 881

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	HisJ	287..>392	CDD:440596	18/114 (16%)
		Lig_chan	405..662	CDD:459656	61/293 (21%)
Gria4	NP_058959.2	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	26/154 (17%)
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	89/483 (18%)