DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir21a and Gria4

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_001106655.1	Gene:	Gria4 / 29629	RGDID:	61863	Length:	902	Species:	Rattus norvegicus

Alignment Length:	753	Identity:	141/753 - (18%)
Similarity:	266/753 - (35%)	Gaps:	224/753 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 FHVNSYNFEQTNSLVGLVNKIAQ-EYL-NKCPP----VIYYDSFV-----------EKSD----- 126
            |.:..:|......|:....|:.| ||. ::.||    .:.||..:           :|.|
  Rat   262 FQLVDFNTPMVTKLMDRWKKLDQREYPGSETPPKYTSALTYDGVLVMAETFRSLRRQKIDISRRG 326

  Fly   127 ---------------GLILENLFKTIPITFYHGEINADYEAKNKRFTSHIDCNCKSYILFLSDPL 176
                           |:.:|...|.:.|....|.:..|:..:...:|..:      :.|..:.|
  Rat   327 NAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMDV------FELKSTGP- 384

  Fly   177 MTRKILGPQTESRVVLVSRSTQWRLRDF--LSSELSSNIVNLLVIGESLMADPMRERPYVLY--T 237
              ||:.......::||:        :|.  |.::.:: |.|..|:..::|     |.|||:|  .
  Rat   385 --RKVGYWNDMDKLVLI--------QDMPTLGNDTAA-IENRTVVVTTIM-----ESPYVMYKKN 433

  Fly   238 HKLYADGLGSNTPVVLTSWIKGALSRPHINLFPSKFQFGFAGHRFQISAANQPPFIFRIRTLDSS 302
            |:::.
  Rat   434 HEMFE------------------------------------------------------------ 438

  Fly   303 GMGQLRWDGVEFRLLTMISKRLNFSIDITETP-----TRSNTRGVVDTIQEQIIERTVDIGMSGI 362
              |..:::|....|.:.|:|.:.....|...|     .|.....:.:.:..:::....:|.::.:
  Rat   439 --GNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPL 501

  Fly   363 YIT--QERLMDSA---MSVGHSPDCAAFITLASKALPKYRAIMGPFQWPVWVALICVYLGGIFPI 422
            .||  :|.::|.:   ||:|.|    ..|....|:.|...:.:.|..:.:|:.::..|: |:..:
  Rat   502 TITLVREEVIDFSKPFMSLGIS----IMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYI-GVSVV 561

  Fly   423 VFTDRLTLSHLMGNWGEVENMFWYV-----------------FGMFTNAFSFTGKYSWS----NT 466
            :|        |:..:...|   |:.                 ||:|.:.:...|.:...    :.
  Rat   562 LF--------LVSRFSPYE---WHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISP 615

  Fly   467 RKNSTRLLIGAYWLFTIIITSCYTGSIIAFVTLPAFPDTVDSVLDLL-GLFFRVGTLNNGGWETW 530
            |..|.|::.|.:|.||:||.|.||.::.||:|:......::|..||. ......|||::|..:.:
  Rat   616 RSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEF 680

  Fly   531 FQNSTHIPTSRLYKKM----------EFVGSVDEGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFS 585
            |:.|    ...:|:||          .|..:..||:..|.:| ...:|||......||:.|....
  Rat   681 FRRS----KIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKS-KGKFAFLLESTMNEYIEQRKPC 740

  Fly   586 DE-----NISRRSALHLSEECFALFQIGFLFPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVM 645
            |.     |:..:.             .|...|:.|..:..::..:|...:.||:.|:.|:  |..
  Rat   741 DTMKVGGNLDSKG-------------YGVATPKGSSLRNAVNLAVLKLNEQGLLDKLKNK--WWY 790

  Fly   646 QRSSSGRLLQASSSNSLREIIQEERQLTTADTEGMFLLMALGYFLGATALVSEIVGGITNKCRQI 710
            .:...|     |.....::   :...|:.::..|:|.::..|  ||...||:.|  ....|.|..
  Rat   791 DKGECG-----SGGGDSKD---KTSALSLSNVAGVFYILVGG--LGLAMLVALI--EFCYKSRAE 843

  Fly   711 IKRSR---KSAASSWSSASSGSMLRTNAEQLSHDKRKA 745
            .||.:   ..|..:.:..|....:..|...|:.|..||
  Rat   844 AKRMKLTFSEAIRNKARLSITGSVGENGRVLTPDCPKA 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	70/335 (21%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	62/291 (21%)
Gria4	NP_001106655.1	PBP1_iGluR_AMPA_GluR4	28..398	CDD:107383	24/144 (17%)
		ANF_receptor	39..380	CDD:279440	20/123 (16%)
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	90/483 (19%)
		Lig_chan	546..825	CDD:278489	66/320 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910