Protein Alignment Ir21a and Gria3

DIOPT Version :10

• Sequence 1: NP_001097043.1
• Gene: Ir21a / 33157
• FlyBaseID: FBgn0031209
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: NP_116785.2
• Gene: Gria3 / 29628
• RGDID: 70958
• Length: 888
• Species: Rattus norvegicus
• Alignment Length: 711
• Identity: 132/711 - (18%)
• Similarity: 245/711 - (34%)
• Gaps: 227/711 - (31%)

  Fly   125 SDGLILENLFKTIPITFYHGEINADYEAKNKRFTSHIDCNCKSYILFLSDPLMTRKILGPQTESR 189
            |.|:.:|...|.:.:....|.|..|...:...:|  ||             :...|:.|.:
  Rat   343 SQGIDIERALKMVQVQGMTGNIQFDTYGRRTNYT--ID-------------VYEMKVSGSR---- 388

  Fly   190 VVLVSRSTQW----RLRDFLSSEL---SSNIVNLLVIGESLMADPMRERPYVLYTHKLYADGLGS 247
                 ::..|    |...|...::   ||:..|..::..:::     |.|||:|
  Rat   389 -----KAGYWNEYERFVPFSDQQISNDSSSSENRTIVVTTIL-----ESPYVMY----------- 432

  Fly   248 NTPVVLTSWIKGALSRPHINLFPSKFQFGFAGHRFQISAANQPPFIFRIRTLDSSGMGQLRWDGV 312
                          .:.|..|                                   .|..|::|.
  Rat   433 --------------KKNHEQL-----------------------------------EGNERYEGY 448

  Fly   313 EFRLLTMISK--RLNFSIDI-------TETPTRSNTRGVVDTIQEQIIERTVDIGMSGIYIT--Q 366
            ...|...|:|  |:.:.:.|       ...|......|:|.    :::....||.::.:.||  :
  Rat   449 CVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVG----ELVYGRADIAVAPLTITLVR 509

  Fly   367 ERLMDSA---MSVGHSPDCAAFITLASKALPKYRAIMGPFQWPVWVALICVYLGGIFPIVFTDRL 428
            |.::|.:   ||:|.|    ..|....|:.|...:.:.|..:.:|:.::..|: |:..::|
  Rat   510 EEVIDFSKPFMSLGIS----IMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYI-GVSVVLF---- 565

  Fly   429 TLSHLMGNWGEVENMFWYV-------------------FGMFTNAFSFTGKYSWS----NTRKNS 470
                |:..:...|   |::                   ||:|.:.:...|.:...    :.|..|
  Rat   566 ----LVSRFSPYE---WHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLS 623

  Fly   471 TRLLIGAYWLFTIIITSCYTGSIIAFVTLPAFPDTVDSVLDLL-GLFFRVGTLNNGGWETWFQNS 534
            .|::.|.:|.||:||.|.||.::.||:|:......::|..||. ......|||::|..:.:|:.|
  Rat   624 GRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRS 688

  Fly   535 THIPTSRLYKKME------FVGSVDEGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFSDE-----N 588
            ......:::..|:      |..:..:|:..|.:| ...:|||......||:.|....|.     |
  Rat   689 KIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKS-KGKFAFLLESTMNEYIEQRKPCDTMKVGGN 752

  Fly   589 ISRRSALHLSEECFALFQIGFLFPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRL 653
            :..:.             .|...|:.|.....::..:|...:.|::.|:.|:  |...:...|
  Rat   753 LDSKG-------------YGVATPKGSALGTPVNLAVLKLSEQGILDKLKNK--WWYDKGECG-- 800

  Fly   654 LQASSSNSLREIIQEERQLTTADTEGMFLLMALGYFLGATALVSEIVGGITNKCRQIIKRSRKSA 718
              |..|.|.    .:...|:.::..|:|.::..|  ||...:|:            :|:...||.
  Rat   801 --AKDSGSK----DKTSALSLSNVAGVFYILVGG--LGLAMMVA------------LIEFCYKSR 845

  Fly   719 ASSWSSASSGSMLRTNAEQLSHDKRKANRREAAEVAQKMSFGMRELNLTRATLREIYGSYG 779
            |.|              :::...|...|.:.|.....:          ..||.||.|..||
  Rat   846 AES--------------KRMKLTKNTQNFKPAPATNTQ----------NYATYREGYNVYG 882

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	HisJ	287..>392	CDD:440596	22/118 (19%)
		Lig_chan	405..662	CDD:459656	59/291 (20%)
Gria3	NP_116785.2	PBP1_iGluR_AMPA_GluR3	29..403	CDD:380610	14/83 (17%)
		PBP2_iGluR_AMPA	416..799	CDD:270433	89/483 (18%)