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Protein Alignment Ir21a and GRIN2D

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_000827.2	Gene:	GRIN2D / 2906	HGNCID:	4588	Length:	1336	Species:	Homo sapiens

Alignment Length:	593	Identity:	115/593 - (19%)
Similarity:	214/593 - (36%)	Gaps:	126/593 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 RKILGPQTESRVVLVSRSTQWRLRDF-LSSELSSN--IVNLLVIGESLMADPMRERPYVLYTHKL 240
            |..|..:..:.|.:|:|..|..|||: ...||..:  ..|....||||....|.    :.:.::.
Human   313 RDDLARRVAAGVAVVARGAQALLRDYGFLPELGHDCRAQNRTHRGESLHRYFMN----ITWDNRD 373

  Fly   241 YA---DGLGSNTPVVLTS------W-IKGALSRPHINL-FPSKFQFGFAGHRF----------QI 284
            |:   ||...|..:|:.|      | :.|:..:..:.| :|...::|    ||          .:
Human   374 YSFNEDGFLVNPSLVVISLTRDRTWEVVGSWEQQTLRLKYPLWSRYG----RFLQPVDDTQHLTV 434

  Fly   285 SAANQPPFIFRIRTLDSSGMGQLRWDGVEFR---------------------------LLTMISK 322
            :...:.||:. :...|......:| |.|..|                           :|..::.
Human   435 ATLEERPFVI-VEPADPISGTCIR-DSVPCRSQLNRTHSPPPDAPRPEKRCCKGFCIDILKRLAH 497

  Fly   323 RLNFSID---ITETPTRSNTRGVVDTIQEQIIERTVDIGMSGIYITQERLMDSAMSVGHSPDCAA 384
            .:.||.|   :|.........||.:.:..::..:..|:.:..:.|.:||......||.......:
Human   498 TIGFSYDLYLVTNGKHGKKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGIS 562

  Fly   385 FITLASKALPKYRAIMGPFQWPVWVAL--ICVYLGGIFPIVF---------TDRLTLSHLMGNWG 438
            .:...|.......|.:.|:...|||.:  :|:.:..:...:|         ....|.....|:..
Human   563 VMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGGSTF 627

  Fly   439 EVENMFWYVFGMFTNAFSFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTGSIIAFVTLPAFP 503
            .:....|.::     |..|.......|.|..::::::..:..|.:|..:.||.::.||:....:.
Human   628 TIGKSIWLLW-----ALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYV 687

  Fly   504 DTVDSVLDLLGLF---------FRVGTLNNGGWETWFQNSTHIPTSRLYKKMEFVGSVDEGI--- 556
            |||..:.|  ..|         .:.||:.||..|...:  ::.|....|........|:|.:
Human   688 DTVSGLSD--RKFQRPQEQYPPLKFGTVPNGSTEKNIR--SNYPDMHSYMVRYNQPRVEEALTQL 748

  Fly   557 --GNVTQSFFWNYAFLGSKAQLEYLVQSNFSDENISRRSALHLSEECFALFQIGFLFPRESVYKI 619
              |.:.       ||:...|.|.|:.:.:...:.::..|.     :.||....|....:.|.:|.
Human   749 KAGKLD-------AFIYDAAVLNYMARKDEGCKLVTIGSG-----KVFATTGYGIALHKGSRWKR 801

  Fly   620 KIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLREIIQEERQLTTADTEGMF--L 682
            .||  :.|.|..|     ::|:..:.:...||     ...|...|::..  :|...:..|:|  |
Human   802 PID--LALLQFLG-----DDEIEMLERLWLSG-----ICHNDKIEVMSS--KLDIDNMAGVFYML 852

  Fly   683 LMALGYFL 690
            |:|:|..|
Human   853 LVAMGLSL 860

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.