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Protein Alignment Ir21a and GRIN2B

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_000825.2	Gene:	GRIN2B / 2904	HGNCID:	4586	Length:	1484	Species:	Homo sapiens

Alignment Length:	579	Identity:	108/579 - (18%)
Similarity:	199/579 - (34%)	Gaps:	108/579 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   316 LLTMISKRLNFSID---ITETPTRSNTRGVVDTIQEQIIERTVDIGMSGIYITQERLMDSAMSVG 377
            :|..|||.:.|:.|   :|.........|..:.:..:::.:...:.:..:.|.:||......||.
Human   464 ILKKISKSVKFTYDLYLVTNGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVP 528

  Fly   378 HSPDCAAFITLASKALPKYRAIMGPFQWPVW----VALICVYLGGIFPIVFTDRLTLSHLMGNWG 438
            ......:.:...|.......|.:.||...||    |.|:.|....:|...:...:..:..:.:..
Human   529 FIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGR 593

  Fly   439 E-------VENMFWYVFGMFTNAFSFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTGSIIAF 496
            |       :....|.::|:.     |.......|.:..::::::..:..|.:|..:.||.::.||
Human   594 EPGGPSFTIGKAIWLLWGLV-----FNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAF 653

  Fly   497 VTLPAFPDTVDSVLDL-------LGLFFRVGTLNNGGWETWFQNSTHIPTSRLYKKME-FVGSVD 553
            :....:.|.|..:.|.       ....||.||:.||..|...:|:        |.:|. ::|..:
Human   654 MIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNN--------YAEMHAYMGKFN 710

  Fly   554 E-GIGNVTQSFFWNY--AFLGSKAQLEYLVQSNFSDENISRRSALHL----SEECFALFQIGFLF 611
            : |:.:...|.....  ||:...|.|.|:.         .|.....|    |.:.||....|...
Human   711 QRGVDDALLSLKTGKLDAFIYDAAVLNYMA---------GRDEGCKLVTIGSGKVFASTGYGIAI 766

  Fly   612 PRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLREIIQEERQLTTAD 676
            .::|.:|.::|..||.....|.:.::  |..|          |.....|...|::..  ||...:
Human   767 QKDSGWKRQVDLAILQLFGDGEMEEL--EALW----------LTGICHNEKNEVMSS--QLDIDN 817

  Fly   677 TEGMFLLMALGYFLGATALVSEIVGGITNKCRQIIKRSRKSAASSWSSASSGSMLRTN------A 735
            ..|:|      |.|||...:|.    ||..|..:.....:.......|...|.:...:      .
Human   818 MAGVF------YMLGAAMALSL----ITFICEHLFYWQFRHCFMGVCSGKPGMVFSISRGIYSCI 872

  Fly   736 EQLSHDKRKANRREAAEVAQKMSFGMRELNLTRATLREIYGSYGAPETDHGQLDIVHTE------ 794
            ..::.::|::...............:..|..|...:..:.|..|:|::   .||.:..|
Human   873 HGVAIEERQSVMNSPTATMNNTHSNILRLLRTAKNMANLSGVNGSPQS---ALDFIRRESSVYDI 934

  Fly   795 ------FPNSSAK-LNNIEDEES---------REALESLQRLDE--FMDQMDNDGNPSS 835
                  |.:|..| .||...||:         .....:||..|.  :.|...:...|.|
Human   935 SEHRRSFTHSDCKSYNNPPCEENLFSDYISEVERTFGNLQLKDSNVYQDHYHHHHRPHS 993

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.