Protein Alignment Ir21a and GRIN2A

DIOPT Version :9

• Sequence 1: NP_001097043.1
• Gene: Ir21a / 33157
• FlyBaseID: FBgn0031209
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: XP_016878661.1
• Gene: GRIN2A / 2903
• HGNCID: 4585
• Length: 1516
• Species: Homo sapiens
• Alignment Length: 877
• Identity: 158/877 - (18%)
• Similarity: 296/877 - (33%)
• Gaps: 243/877 - (27%)

  Fly    65 IVPTF-QGN----PR--PRGELLASKFHVNSYNFE-QTNSLVGLVNKIAQEYLNKCPPVIYYDSF 121
            |||:. .||    |:  |.| |::..:....|:.| :....:|::...|...|.|.       |:
Human   308 IVPSLVSGNTELIPKEFPSG-LISVSYDDWDYSLEARVRDGIGILTTAASSMLEKF-------SY 364

  Fly   122 VEKSDGLILENLFK-TIPI-TFYHGEINADYEAKNKRFTSHIDCNCKSYILFLSDPLMTRKILGP 184
            :.::.......:.: .:|: |.:...:|..::.|:..||..                      |.
Human   365 IPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEE----------------------GY 407

  Fly   185 QTESR--VVLVSRSTQW-------------------RLRDFLSSELSSNIVNLLVIGESLMADPM 228
            |...|  |:::::..:|                   |.:.|...|...|.::::.         :
Human   408 QVHPRLVVIVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVT---------L 463

  Fly   229 RERPYVLYTHKLYADGLGSNTPVVLTSWIKGALSRPHINLFPSKFQFGFAGHRFQISAANQPPFI 293
            .|.|:|:      .:.:...|...:.            |..|.:                  .|:
Human   464 EEAPFVI------VEDIDPLTETCVR------------NTVPCR------------------KFV 492

  Fly   294 FRIRTLDSSGMGQLR-WDGVEFRLLTMISKRLNFSIDITETPTRSNTRGVVDT----IQEQIIER 353
             :|....:.||...: ..|....:|..:|:.:.|:.|:.......:.:.|.:.    |.|.:.:|
Human   493 -KINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQR 556

  Fly   354 TVDIGMSGIYITQERLMDSAMSVGHSPDCAAFITLASKALPKYRAIMGPFQWPVWVAL------- 411
            .| :.:..:.|.:||......||.......:.:...|.......|.:.||...|||.:
Human   557 AV-MAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIV 620

  Fly   412 --ICVYLGGIF-PIVFTDRLT---LSHLMGNWGEVENMFWYVFGMFTNAFSFTGKYSWSNTRKNS 470
              |.|::...| |:.:...|.   ..|  |....:....|.::|:.     |.......|.:..:
Human   621 SAIAVFVFEYFSPVGYNRNLAKGKAPH--GPSFTIGKAIWLLWGLV-----FNNSVPVQNPKGTT 678

  Fly   471 TRLLIGAYWLFTIIITSCYTGSIIAFVTLPAFPDTVDSVLDLLGLF---------FRVGTLNNGG 526
            :::::..:..|.:|..:.||.::.||:....|.|.|..:.|  ..|         ||.||:.||.
Human   679 SKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSD--KKFQRPHDYSPPFRFGTVPNGS 741

  Fly   527 WETWFQNSTHIPTSRLY-KKMEFVGSVDEGIGNVT---QSFFWNYAFLGSKAQLEYLVQSNFSDE 587
            .|...:|  :.|....| .|....|..|..:...|   .:|.::.|.|..||
Human   742 TERNIRN--NYPYMHQYMTKFNQKGVEDALVSLKTGKLDAFIYDAAVLNYKA------------- 791

  Fly   588 NISRRSALHL----SEECFALFQIGFLFPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRS 648
              .|.....|    |...||....|....:.|.:|.:||..:|.....|.:.::  |..|
Human   792 --GRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEEL--ETLW----- 847

  Fly   649 SSGRLLQASSSNSLREIIQEERQLTTADTEGMFLLMALGYFLGA-----------------TALV 696
                 |.....|...|::..  ||...:..|:|.::|....|..                 |.:.
Human   848 -----LTGICHNEKNEVMSS--QLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLRFCFTGVC 905

  Fly   697 SEIVGGITNKCRQI--------IKRSRKSAASSWSSASSGSM-LRTNAEQLS-----HDKRKANR 747
            |:..|.:.:..|.|        |:..:||...:.:.:.|..: |..:|:.:|     :..|..:.
Human   906 SDRPGLLFSISRGIYSCIHGVHIEEKKKSPDFNLTGSQSNMLKLLRSAKNISSMSNMNSSRMDSP 970

  Fly   748 REAAEVAQKMSFGMREL----NLTRATLREIYGSYGAPETDHGQLDIVHTEFPNSSAKLNNIEDE 808
            :.||:..|:.|..|..:    ||..:..|...|.    |:..|                :|:.:.
Human   971 KRAADFIQRGSLIMDMVSDKGNLMYSDNRSFQGK----ESIFG----------------DNMNEL 1015

  Fly   809 ESREALESLQRLDEFMDQMD-----NDGNPSS 835
            ::..|......|:.::.|..     |:.||::
Human  1016 QTFVANRQKDNLNNYVFQGQHPLTLNESNPNT 1047

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	67/324 (21%)
		Lig_chan	407..662	CDD:278489	60/284 (21%)
GRIN2A	XP_016878661.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810