DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ir21a and GRIK4

DIOPT Version :9

Sequence 1:NP_001097043.1 Gene:Ir21a / 33157 FlyBaseID:FBgn0031209 Length:842 Species:Drosophila melanogaster
Sequence 2:NP_001269399.1 Gene:GRIK4 / 2900 HGNCID:4582 Length:956 Species:Homo sapiens


Alignment Length:853 Identity:169/853 - (19%)
Similarity:292/853 - (34%) Gaps:297/853 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 RLINHYQLNKEIFGVGMCDGNNE-----NEFRQKRRIVPTFQGNPRPRGELLASKFH-------- 85
            :|:..:.::|:...|.|.|...:     .|.|..:........|        ||..|        
Human   177 KLLRQFLISKDTLSVRMLDDTRDPTPLLKEIRDDKTATIIIHAN--------ASMSHTILLKAAE 233

  Fly    86 ---VNSY----------NFEQTNSLV-GLVNKIAQEYLNKCPPVIYYDSFVEK------------ 124
               |::|          :.::.:||| ..||.:.....|:..  .::..|.:.            
Human   234 LGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSH--AFFQEFAQSLNQSWQENCDHV 296

  Fly   125 -------SDGLILENLFKTI---------------PIT------FYHGEINADY--EAKNKRFTS 159
                   |..|:.:.::..:               |::      :.||....:|  ..:.:..|.
Human   297 PFTGPALSSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLTG 361

  Fly   160 HIDCNCK----SYILFLSDPLMTRKILGPQTESRVVLVSRS-----TQWRLRDFLSSELSSNIVN 215
            ||:.|.|    :|.|                  :::..:|:     .||.:.:.||.:       
Human   362 HIEFNSKGQRSNYAL------------------KILQFTRNGFRQIGQWHVAEGLSMD------- 401

  Fly   216 LLVIGESLMADPMRERPYVLYTHKLYADGLGS---NTPVVLTSWIKGALSRPHINLFPSKFQFGF 277
                                 :| |||..:..   ||.:|:|:    .|..|::.|         
Human   402 ---------------------SH-LYASNISDTLFNTTLVVTT----ILENPYLML--------- 431

  Fly   278 AGHRFQISAANQPPFIFRIRTLDSSGMGQLRWDGVEFRLLTMISKRLNFSIDIT-------ETPT 335
            .|:..::.                   |..|::|....:|..:::.|.|:..|.       ..|.
Human   432 KGNHQEME-------------------GNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPE 477

  Fly   336 RSNT-RGVVDTIQEQIIERTVDIGMSGIYITQER--LMDSAMSVGHSPDCAAFITLASKAL---- 393
            .:.| .|:|.    ::|.|..|:.::|:.||.||  ::|.:         ..|:||....|    
Human   478 ANGTWTGMVG----ELIARKADLAVAGLTITAEREKVIDFS---------KPFMTLGISILYRVH 529

  Fly   394 ----PKYRAIMGPFQWPVWVALICVYLGGIFPIVFTDRLT-------------LSHLMGNWGEVE 441
                |.|.:.:.||...||:.::..||.....:....|||             ..:|:.|...:.
Human   530 MGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLG 594

  Fly   442 NMFWYVFGMFTNAFSFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTGSIIAFVTLPAFPDTV 506
            |..|:..|      .|..:.|....|..|||.:.|.:|.||:||.|.||.::.||:|:......:
Human   595 NSLWFPVG------GFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPI 653

  Fly   507 DSVLDLLG-LFFRVGTLNNGGWETWFQNSTHIPTSRLYKKM------EFVGSVDEGIGNVTQSFF 564
            :||.||.. .....||::.|...|:||||.:....|::..|      .||.|.:|||..|..|  
Human   654 ESVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNS-- 716

  Fly   565 WNYAFLGSKAQLEYLVQSNFSDENISRRSALHLSEECFALFQIGFL---------FPRESVYKIK 620
             |||||......||..|.|.:                  |.|||.|         .|..||::.:
Human   717 -NYAFLLESTMNEYYRQRNCN------------------LTQIGGLLDTKGYGIGMPVGSVFRDE 762

  Fly   621 IDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLREIIQEERQLTTADTEGMFLLMA 685
            .|..||..|:       ||.:..:.::...|       ....:|.....:.|...:..|:|:::.
Human   763 FDLAILQLQE-------NNRLEILKRKWWEG-------GKCPKEEDHRAKGLGMENIGGIFVVLI 813

  Fly   686 LGYFLGATALVSEIVGGITNK-------CRQIIKRSRKSAASSWSSASSGSMLRTNAEQLSHDKR 743
            .|..:.....:.|.:..:.:.       |::::...|             |::      |..|..
Human   814 CGLIVAIFMAMLEFLWTLRHSEATEVSVCQEMVTELR-------------SII------LCQDSI 859

  Fly   744 KANRREAA 751
            ...||.||
Human   860 HPRRRRAA 867

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir21aNP_001097043.1 Periplasmic_Binding_Protein_Type_2 289..583 CDD:304360 88/331 (27%)
Lig_chan 407..662 CDD:278489 76/283 (27%)
GRIK4NP_001269399.1 PBP1_iGluR_Kainate_KA1_2 26..400 CDD:107389 37/250 (15%)
ANF_receptor 43..382 CDD:279440 33/232 (14%)
PBP2_iGluR_kainate_KA1 415..785 CDD:270442 111/448 (25%)
Lig_chan 547..816 CDD:278489 80/309 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 863..889 4/5 (80%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 931..956
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1052
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR18966
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.910

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