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Protein Alignment Ir21a and GRIK1

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_001317923.1	Gene:	GRIK1 / 2897	HGNCID:	4579	Length:	949	Species:	Homo sapiens

Alignment Length:	654	Identity:	144/654 - (22%)
Similarity:	248/654 - (37%)	Gaps:	151/654 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 LGPQTESRVVLVSRSTQWRLRDFLSSELSSN------------IVNLLVIGESLMADPMRERPYV 234
            |||    |.:.:.:..:|   |.|:..::.|            |::|...|....|..:.:..|.
Human   356 LGP----RFMNLIKEARW---DGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYK 413

  Fly   235 LYTHKLYADGL-GSNTPVVLTSWIKGALSRPHINLFPSKFQFGFAGHRFQISAANQPPFIFRIRT 298
            :: .|:   |: .||:.:.:|...|...|    |:..|     .|.....::...:.|::. .|.
Human   414 VW-KKI---GIWNSNSGLNMTDSNKDKSS----NITDS-----LANRTLIVTTILEEPYVM-YRK 464

  Fly   299 LDSSGMGQLRWDGVEFRLLTMISKRLNFSIDITETPT----RSNTRGVVDTIQEQIIERTVDIGM 359
            .|....|..|::|....||..:|..|.|..|:...|.    ..|.:|..:.:.:::|:...|:.:
Human   465 SDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAV 529

  Fly   360 SGIYIT--QERLMDSAMSVGHSPDCAAFITLASKAL--------PKYRAIMGPFQWPVWVALICV 414
            :.:.||  :|:::|.:         ..|:||....|        |...:.:.|....:|:.::..
Human   530 APLTITYVREKVIDFS---------KPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLA 585

  Fly   415 YLGGIFPIVFTDRLTL------------SHLMGNWGEVENMFWYVFGMFTNAFSFTGKYSWSNTR 467
            .||....:....|.|.            |.::.|...:.|.||:..|      :...:.|....:
Human   586 CLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVG------ALMQQGSELMPK 644

  Fly   468 KNSTRLLIGAYWLFTIIITSCYTGSIIAFVTLPAFPDTVDSVLDLL-GLFFRVGTLNNGGWETWF 531
            ..|||::.|.:|.||:||.|.||.::.||:|:......:||..||. ......|.:.:|...|:|
Human   645 ALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFF 709

  Fly   532 QNSTHIPTSRLYKKM----------EFVGSVDEGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFSD 586
            :.| .|.|   |:||          ..|.:.||||..|..:   :||.|.....:||:.|.|.:
Human   710 KKS-KIST---YEKMWAFMSSRQQTALVRNSDEGIQRVLTT---DYALLMESTSIEYVTQRNCN- 766

  Fly   587 ENISRRSALHLSEECFALFQIGFLF---------PRESVYKIKIDSMILLAQQSGLIAKINNEVS 642
                             |.|||.|.         |..|.|:.||...||..|:.|.: .:..|..
Human   767 -----------------LTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKL-HMMKEKW 813

  Fly   643 WVMQRSSSGRLLQASSSNSLREIIQEERQLTTADTEGMFLLMALGYFLGATALVSEIVGGITNKC 707
            |             ..:....|..:|...|...:..|:|:::|.|..|.....:.|
Human   814 W-------------RGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGE--------- 856

  Fly   708 RQIIKRSRKSAASSWSSASSGSMLRTNAEQLSHDKRKANRREAAEVAQKMSFG--MRELNLTRAT 770
              .|.:|||:........||........:...|.::|    ::..|.:.:||.  |.||.::...
Human   857 --FIYKSRKNNDIEQKGKSSRIRFYFRNKVRFHGRKK----QSLGVEKCLSFNAIMEELGISLKN 915

  Fly   771 LREI 774
            .::|
Human   916 QKKI 919

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.