Protein Alignment Ir21a and GRID2

DIOPT Version :9

• Sequence 1: NP_001097043.1
• Gene: Ir21a / 33157
• FlyBaseID: FBgn0031209
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: XP_011530195.2
• Gene: GRID2 / 2895
• HGNCID: 4576
• Length: 1035
• Species: Homo sapiens
• Alignment Length: 636
• Identity: 124/636 - (19%)
• Similarity: 228/636 - (35%)
• Gaps: 180/636 - (28%)

  Fly   237 THKLYADGLGSNTPVVLTSWIKGALSRPHINLFPSKFQFGFAGHRFQISAANQPPFIFRIRTLDS 301
            |.|::.. ||...||   :.:.|:|:       ..|.:....|...::....:.||:.    :..
Human   437 TGKIWPQ-LGCWNPV---TGLNGSLT-------DKKLENNMRGVVLRVVTVLEEPFVM----VSE 486

  Fly   302 SGMGQ-LRWDGVEFRLLTMISKRLNFSIDITETPTRS----NTRGVVDTIQEQIIERTVDIGMSG 361
            :.:|: .::.|....:|..:|..|.|:.:|...|...    ...|..:.:..:::.:..|||:|.
Human   487 NVLGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISA 551

  Fly   362 IYITQE---------RLMDSAMSVGHSPDCAAFITLASKALPKYRAIMGPFQWPVW--------- 408
            :.||.:         |.||.::.|        .:..|.|.:..: |.:.||...:|
Human   552 LTITPDRENVVDFTTRYMDYSVGV--------LLRRAEKTVDMF-ACLAPFDLSLWACIAGTVLL 607

  Fly   409 VALICVYLGGIFPIVFTDRLTLSHLMGNWGEVENMFWYVFGMFTNAFSFTGKYSWSNTRKNSTRL 473
            |.|:...|..:.|    .||.:..:...  .:.|..|:|:|.|...   .|:..::..   :||:
Human   608 VGLLVYLLNWLNP----PRLQMGSMTST--TLYNSMWFVYGSFVQQ---GGEVPYTTL---ATRM 660

  Fly   474 LIGAYWLFTIIITSCYTGSIIAFVTLPAFPDTVDSVLDLLGLFFRVGTLNNGGWETWFQNSTHIP 538
            ::||:|||.:|:.|.||.::.||:|:.....::.|:.||                   ...|.||
Human   661 MMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQDL-------------------SKQTEIP 706

  Fly   539 -----TSRLYKKMEFVG-------------------------SVDEGIGNVTQSFFWNYAFLGSK 573
                 .|.:|:.:...|                         :|.|....:.:..:.||||:...
Human   707 YGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRSNGSENNVLESQAGIQKVKYGNYAFVWDA 771

  Fly   574 AQLEYLVQSNFSDENISRRSALHLSEECFALFQIGFLFPRESVYKIKIDSMILLAQQSGLIAKIN 638
            |.|||:.   .:|.:.|    .:......|....|......|.|:......||..||:|.:..:.
Human   772 AVLEYVA---INDPDCS----FYTIGNTVADRGYGIALQHGSPYRDVFSQRILELQQNGDMDILK 829

  Fly   639 NEVSWVMQRSSSGRLLQASSSNSLREIIQEERQLTTADTEGMFLLMALGYFLGATALVSEIVGGI 703
            ::  |..:..      |....:|: :..|:...|......|:|.::|.|..|.....:.|
Human   830 HK--WWPKNG------QCDLYSSV-DTKQKGGALDIKSFAGVFCILAAGIVLSCFIAMLE----- 880

  Fly   704 TNKCRQIIKRSRKSAASSWSSASSGSMLRTNAEQLSHDKRKANRREAAEVAQKMSFGMRELNLTR 768
                             :|                 .:|||.:|..:.|..:::.
Human   881 -----------------TW-----------------WNKRKGSRVPSKEDDKEID---------- 901

  Fly   769 ATLREIYGSYGAPETDHGQLDIVHTEFPNSSAKLN--NIEDEESREALESL 817
              |..::....:..||.   |..|.:|..||..|.  :|:...:|:|||.:
Human   902 --LEHLHRRVNSLCTDD---DSPHKQFSTSSIDLTPLDIDTLPTRQALEQI 947

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	72/346 (21%)
		Lig_chan	407..662	CDD:278489	59/293 (20%)
GRID2	XP_011530195.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810