Protein Alignment Ir21a and GRID1

DIOPT Version :10

• Sequence 1: NP_001097043.1
• Gene: Ir21a / 33157
• FlyBaseID: FBgn0031209
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: NP_060021.1
• Gene: GRID1 / 2894
• HGNCID: 4575
• Length: 1009
• Species: Homo sapiens
• Alignment Length: 944
• Identity: 186/944 - (19%)
• Similarity: 324/944 - (34%)
• Gaps: 267/944 - (28%)

  Fly     5 WVALVLFTAQAFSIEG-------------DRSASYQEKCISRRLINHYQLNKEIFGVGMCDGNNE 56
            |...|:|....:.|.|             |.|....:|.||....:.:...|.         ...
Human   162 WQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKT---------EEL 217

  Fly    57 NEFRQKRRIVPTFQGNPRPRGELLASKFHVNSYNFE--QTNSLVGLVNKIAQ-EYLNKCPPVIYY 118
            |.:|...|           |..||.|....:|:..|  :||    |.:|.:. .::|:
Human   218 NRYRDTLR-----------RAILLLSPQGAHSFINEAVETN----LASKDSHWVFVNE------- 260

  Fly   119 DSFVEKSDGLILE------NLFKTIPITFYHGEINADYEAKNKRFTSHIDCNCKSYI-------L 170
                |.||..||:      .....:...|...:.|......|.|.:|.:....:.|:       |
Human   261 ----EISDPEILDLVHSALGRMTVVRQIFPSAKDNQKCTRNNHRISSLLCDPQEGYLQMLQISNL 321

  Fly   171 FLSDPLMT------RKILGPQTESRVVL--VSRSTQ-WR-LRDFLSSELSSNIVNLLVIGESLMA 225
            :|.|.::.      ||:...:..|...|  :.:||: |. .|..|.:....:|..|..:.|
Human   322 YLYDSVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTGVME---- 382

  Fly   226 DPMRE---RPYVLY--THKLYADGLGSNTPVVLTSW-----IKGAL-SRPHINLFPSKFQFGFAG 279
              .||   .|||.:  ....|::..|.:.. .|.:|     :.|:| .||    ..|:.|    |
Human   383 --FREDSSNPYVQFEILGTTYSETFGKDMR-KLATWDSEKGLNGSLQERP----MGSRLQ----G 436

  Fly   280 HRFQISAANQPPFIFRIRTLDSSGMGQ-LRWDGVEFRLLTMISKRLNFSIDITETPT-------- 335
            ...::....:.||:.....:    :|| .|:.|....:|..::|.|.|..:|.:.|.
Human   437 LTLKVVTVLEEPFVMVAENI----LGQPKRYKGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLH 497

  Fly   336 RSNTRGVVDTIQEQIIERTVDIGMSGIYITQE---------RLMDSAMSVGHSPDCAAFITLASK 391
            .::..|::.    ::|.:..|:.:|.|.||.|         |.||.::.:           |..|
Human   498 NTSWNGMIG----ELISKRADLAISAITITPERESVVDFSKRYMDYSVGI-----------LIKK 547

  Fly   392 ALPKYR--AIMGPFQWPVWVALICVYLGGIFPIVFTDRLTLSHLMGNWGE------------VEN 442
            ...|..  ::..||.:.||.   |:  ....|:|......|:.:.....:            :.:
Human   548 PEEKISIFSLFAPFDFAVWA---CI--AAAIPVVGVLIFVLNRIQAVRAQSAAQPRPSASATLHS 607

  Fly   443 MFWYVFGMFTNAFSFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTGSIIAFVTLPAFPDTVD 507
            ..|.|:|      :|..:...|:....:.|:::|::||||:|:.|.||.::.||:|:....:.:.
Human   608 AIWIVYG------AFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIR 666

  Fly   508 SVLDL-LGLFFRVGTLNNGGWETWF---------QNSTHIPTSRLYKKM----EFVGSVDEGIGN 558
            :..|| ..:....||:.:.....:|         |:||.....|...|.    ..|.|..|||..
Human   667 TFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSSPSEGIRK 731

  Fly   559 VTQSFFWNYAFLGSKAQLEYLVQSNFSDENISRRSALHLSEECFALFQIGFLFPRESVYKIKIDS 623
            ..:.   |||||...|.:||   :..:|::.|    :.:.....:....|......|.|:.....
Human   732 AKKG---NYAFLWDVAVVEY---AALTDDDCS----VTVIGNSISSKGYGIALQHGSPYRDLFSQ 786

  Fly   624 MILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLREIIQEERQLTTADTEGMFLLMALGY 688
            .||..|.:|.:..:..:  |............||:.       .:.:.|......|:|.::|:|.
Human   787 RILELQDTGDLDVLKQK--WWPHMGRCDLTSHASAQ-------ADGKSLKLHSFAGVFCILAIGL 842

  Fly   689 FLGATALVSEIVGGITNKCRQIIKRSRKSAASSWSSASSGSMLRTNAEQLSHDKRKANRREAAEV 753
            .|.......|:... :|:|.|...:..|               ..|.||               |
Human   843 LLACLVAALELWWN-SNRCHQETPKEDK---------------EVNLEQ---------------V 876

  Fly   754 AQKMSFGMRELNLTRATLREIYGSYGAPETDHGQLDIVHTEFPNSSAKLNNIED---------EE 809
            .::|:..|.|                         ||.|.:...:|.:|:.:|.         |.
Human   877 HRRMNSLMDE-------------------------DIAHKQISPASIELSALEMGGLAPTQTLEP 916

  Fly   810 SREALESLQRLDEFMDQMDNDG-------NPSSH 836
            :||...:...:..|:.:..:.|       .|||:
Human   917 TREYQNTQLSVSTFLPEQSSHGTSRTLSSGPSSN 950

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	HisJ	287..>392	CDD:440596	24/122 (20%)
		Lig_chan	405..662	CDD:459656	59/282 (21%)
GRID1	NP_060021.1	Interaction with CBLN1. /evidence=ECO:0000250|UniProtKB:Q61627	21..436		66/323 (20%)
		PBP1_iGluR_delta_1	25..425	CDD:380615	61/304 (20%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	86/411 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	930..954		5/21 (24%)