DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir21a and GRID1

DIOPT Version :9

Sequence 1:NP_001097043.1 Gene:Ir21a / 33157 FlyBaseID:FBgn0031209 Length:842 Species:Drosophila melanogaster
Sequence 2:NP_060021.1 Gene:GRID1 / 2894 HGNCID:4575 Length:1009 Species:Homo sapiens


Alignment Length:944 Identity:186/944 - (19%)
Similarity:324/944 - (34%) Gaps:267/944 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 WVALVLFTAQAFSIEG-------------DRSASYQEKCISRRLINHYQLNKEIFGVGMCDGNNE 56
            |...|:|....:.|.|             |.|....:|.||....:.:...|.         ...
Human   162 WQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKT---------EEL 217

  Fly    57 NEFRQKRRIVPTFQGNPRPRGELLASKFHVNSYNFE--QTNSLVGLVNKIAQ-EYLNKCPPVIYY 118
            |.:|...|           |..||.|....:|:..|  :||    |.:|.:. .::|:       
Human   218 NRYRDTLR-----------RAILLLSPQGAHSFINEAVETN----LASKDSHWVFVNE------- 260

  Fly   119 DSFVEKSDGLILE------NLFKTIPITFYHGEINADYEAKNKRFTSHIDCNCKSYI-------L 170
                |.||..||:      .....:...|...:.|......|.|.:|.:....:.|:       |
Human   261 ----EISDPEILDLVHSALGRMTVVRQIFPSAKDNQKCTRNNHRISSLLCDPQEGYLQMLQISNL 321

  Fly   171 FLSDPLMT------RKILGPQTESRVVL--VSRSTQ-WR-LRDFLSSELSSNIVNLLVIGESLMA 225
            :|.|.::.      ||:...:..|...|  :.:||: |. .|..|.:....:|..|..:.|    
Human   322 YLYDSVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTGVME---- 382

  Fly   226 DPMRE---RPYVLY--THKLYADGLGSNTPVVLTSW-----IKGAL-SRPHINLFPSKFQFGFAG 279
              .||   .|||.:  ....|::..|.:.. .|.:|     :.|:| .||    ..|:.|    |
Human   383 --FREDSSNPYVQFEILGTTYSETFGKDMR-KLATWDSEKGLNGSLQERP----MGSRLQ----G 436

  Fly   280 HRFQISAANQPPFIFRIRTLDSSGMGQ-LRWDGVEFRLLTMISKRLNFSIDITETPT-------- 335
            ...::....:.||:.....:    :|| .|:.|....:|..::|.|.|..:|.:.|.        
Human   437 LTLKVVTVLEEPFVMVAENI----LGQPKRYKGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLH 497

  Fly   336 RSNTRGVVDTIQEQIIERTVDIGMSGIYITQE---------RLMDSAMSVGHSPDCAAFITLASK 391
            .::..|::.    ::|.:..|:.:|.|.||.|         |.||.::.:           |..|
Human   498 NTSWNGMIG----ELISKRADLAISAITITPERESVVDFSKRYMDYSVGI-----------LIKK 547

  Fly   392 ALPKYR--AIMGPFQWPVWVALICVYLGGIFPIVFTDRLTLSHLMGNWGE------------VEN 442
            ...|..  ::..||.:.||.   |:  ....|:|......|:.:.....:            :.:
Human   548 PEEKISIFSLFAPFDFAVWA---CI--AAAIPVVGVLIFVLNRIQAVRAQSAAQPRPSASATLHS 607

  Fly   443 MFWYVFGMFTNAFSFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTGSIIAFVTLPAFPDTVD 507
            ..|.|:|      :|..:...|:....:.|:::|::||||:|:.|.||.::.||:|:....:.:.
Human   608 AIWIVYG------AFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIR 666

  Fly   508 SVLDL-LGLFFRVGTLNNGGWETWF---------QNSTHIPTSRLYKKM----EFVGSVDEGIGN 558
            :..|| ..:....||:.:.....:|         |:||.....|...|.    ..|.|..|||..
Human   667 TFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSSPSEGIRK 731

  Fly   559 VTQSFFWNYAFLGSKAQLEYLVQSNFSDENISRRSALHLSEECFALFQIGFLFPRESVYKIKIDS 623
            ..:.   |||||...|.:||   :..:|::.|    :.:.....:....|......|.|:.....
Human   732 AKKG---NYAFLWDVAVVEY---AALTDDDCS----VTVIGNSISSKGYGIALQHGSPYRDLFSQ 786

  Fly   624 MILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLREIIQEERQLTTADTEGMFLLMALGY 688
            .||..|.:|.:..:..:  |............||:.       .:.:.|......|:|.::|:|.
Human   787 RILELQDTGDLDVLKQK--WWPHMGRCDLTSHASAQ-------ADGKSLKLHSFAGVFCILAIGL 842

  Fly   689 FLGATALVSEIVGGITNKCRQIIKRSRKSAASSWSSASSGSMLRTNAEQLSHDKRKANRREAAEV 753
            .|.......|:... :|:|.|...:..|               ..|.||               |
Human   843 LLACLVAALELWWN-SNRCHQETPKEDK---------------EVNLEQ---------------V 876

  Fly   754 AQKMSFGMRELNLTRATLREIYGSYGAPETDHGQLDIVHTEFPNSSAKLNNIED---------EE 809
            .::|:..|.|                         ||.|.:...:|.:|:.:|.         |.
Human   877 HRRMNSLMDE-------------------------DIAHKQISPASIELSALEMGGLAPTQTLEP 916

  Fly   810 SREALESLQRLDEFMDQMDNDG-------NPSSH 836
            :||...:...:..|:.:..:.|       .|||:
Human   917 TREYQNTQLSVSTFLPEQSSHGTSRTLSSGPSSN 950

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir21aNP_001097043.1 Periplasmic_Binding_Protein_Type_2 289..583 CDD:304360 75/339 (22%)
Lig_chan 407..662 CDD:278489 59/280 (21%)
GRID1NP_060021.1 Interaction with CBLN1. /evidence=ECO:0000250|UniProtKB:Q61627 21..436 66/323 (20%)
PBP1_iGluR_delta_1 25..423 CDD:107387 60/302 (20%)
ANF_receptor 41..400 CDD:279440 56/278 (20%)
PBP2_iGluR_delta_1 436..806 CDD:270448 86/411 (21%)
Lig_chan 564..841 CDD:278489 63/306 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 930..954 5/21 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1052
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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