Protein Alignment Ir21a and GRIA4

DIOPT Version :10

• Sequence 1: NP_001097043.1
• Gene: Ir21a / 33157
• FlyBaseID: FBgn0031209
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: NP_000820.4
• Gene: GRIA4 / 2893
• HGNCID: 4574
• Length: 902
• Species: Homo sapiens
• Alignment Length: 673
• Identity: 127/673 - (18%)
• Similarity: 243/673 - (36%)
• Gaps: 187/673 - (27%)

  Fly   127 GLILENLFKTIPITFYHGEINADYEAKNKRFTSHIDCNCKSYILFLSDPLMTRKILGPQTESRVV 191
            |:.:|...|.:.|....|.:..|:..:...:|..:      :.|..:.|   ||:.......::|
Human   342 GIDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMDV------FELKSTGP---RKVGYWNDMDKLV 397

  Fly   192 LVSRSTQWRLRDF--LSSELSSNIVNLLVIGESLMADPMRERPYVLY--THKLYADGLGSNTPVV 252
            |:        :|.  |.::.:: |.|..|:..::|     |.|||:|  .|:::.
Human   398 LI--------QDVPTLGNDTAA-IENRTVVVTTIM-----ESPYVMYKKNHEMFE---------- 438

  Fly   253 LTSWIKGALSRPHINLFPSKFQFGFAGHRFQISAANQPPFIFRIRTLDSSGMGQLRWDGVEFRLL 317
                                                                |..:::|....|.
Human   439 ----------------------------------------------------GNDKYEGYCVDLA 451

  Fly   318 TMISKRLNFSIDITETP-----TRSNTRGVVDTIQEQIIERTVDIGMSGIYIT--QERLMDSA-- 373
            :.|:|.:.....|...|     .|.....:.:.:..:::....:|.::.:.||  :|.::|.:
Human   452 SEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKP 516

  Fly   374 -MSVGHSPDCAAFITLASKALPKYRAIMGPFQWPVWVALICVYLGGIFPIVFTDRLTLSHLMGNW 437
             ||:|.|    ..|....|:.|...:.:.|..:.:|:.::..|: |:..::|        |:..:
Human   517 FMSLGIS----IMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYI-GVSVVLF--------LVSRF 568

  Fly   438 GEVENMFWYV-----------------FGMFTNAFSFTGKYSWS----NTRKNSTRLLIGAYWLF 481
            ...|   |:.                 ||:|.:.:...|.:...    :.|..|.|::.|.:|.|
Human   569 SPYE---WHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFF 630

  Fly   482 TIIITSCYTGSIIAFVTLPAFPDTVDSVLDLL-GLFFRVGTLNNGGWETWFQNSTHIPTSRLYKK 545
            |:||.|.||.::.||:|:......::|..||. ......|||::|..:.:|:.|    ...:|:|
Human   631 TLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRS----KIAVYEK 691

  Fly   546 M----------EFVGSVDEGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFSDE-----NISRRSAL 595
            |          .|..:..||:..|.:| ...:|||......||:.|....|.     |:..:.
Human   692 MWTYMRSAEPSVFTRTTAEGVARVRKS-KGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKG-- 753

  Fly   596 HLSEECFALFQIGFLFPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSN 660
                       .|...|:.|..:..::..:|...::|::.|:.|:  |...:...|.....|...
Human   754 -----------YGVATPKGSSLRTPVNLAVLKLSEAGVLDKLKNK--WWYDKGECGPKDSGSKDK 805

  Fly   661 SLREIIQEERQLTTADTEGMFLLMALGYFLGATALVSEIVGGITNKCRQIIKRSR---KSAASSW 722
            :        ..|:.::..|:|.::..|  ||...||:.|  ....|.|...||.:   ..|..:.
Human   806 T--------SALSLSNVAGVFYILVGG--LGLAMLVALI--EFCYKSRAEAKRMKLTFSEAIRNK 858

  Fly   723 SSASSGSMLRTNAEQLSHDKRKA 745
            :..|....:..|...|:.|..||
Human   859 ARLSITGSVGENGRVLTPDCPKA 881

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	HisJ	287..>392	CDD:440596	18/114 (16%)
		Lig_chan	405..662	CDD:459656	61/293 (21%)
GRIA4	NP_000820.4	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	13/74 (18%)
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	89/483 (18%)