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Protein Alignment Ir21a and GRIA4

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_000820.4	Gene:	GRIA4 / 2893	HGNCID:	4574	Length:	902	Species:	Homo sapiens

Alignment Length:	673	Identity:	127/673 - (18%)
Similarity:	243/673 - (36%)	Gaps:	187/673 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 GLILENLFKTIPITFYHGEINADYEAKNKRFTSHIDCNCKSYILFLSDPLMTRKILGPQTESRVV 191
            |:.:|...|.:.|....|.:..|:..:...:|..:      :.|..:.|   ||:.......::|
Human   342 GIDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMDV------FELKSTGP---RKVGYWNDMDKLV 397

  Fly   192 LVSRSTQWRLRDF--LSSELSSNIVNLLVIGESLMADPMRERPYVLY--THKLYADGLGSNTPVV 252
            |:        :|.  |.::.:: |.|..|:..::|     |.|||:|  .|:::.
Human   398 LI--------QDVPTLGNDTAA-IENRTVVVTTIM-----ESPYVMYKKNHEMFE---------- 438

  Fly   253 LTSWIKGALSRPHINLFPSKFQFGFAGHRFQISAANQPPFIFRIRTLDSSGMGQLRWDGVEFRLL 317
                                                                |..:::|....|.
Human   439 ----------------------------------------------------GNDKYEGYCVDLA 451

  Fly   318 TMISKRLNFSIDITETP-----TRSNTRGVVDTIQEQIIERTVDIGMSGIYIT--QERLMDSA-- 373
            :.|:|.:.....|...|     .|.....:.:.:..:::....:|.::.:.||  :|.::|.:
Human   452 SEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKP 516

  Fly   374 -MSVGHSPDCAAFITLASKALPKYRAIMGPFQWPVWVALICVYLGGIFPIVFTDRLTLSHLMGNW 437
             ||:|.|    ..|....|:.|...:.:.|..:.:|:.::..|: |:..::|        |:..:
Human   517 FMSLGIS----IMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYI-GVSVVLF--------LVSRF 568

  Fly   438 GEVENMFWYV-----------------FGMFTNAFSFTGKYSWS----NTRKNSTRLLIGAYWLF 481
            ...|   |:.                 ||:|.:.:...|.:...    :.|..|.|::.|.:|.|
Human   569 SPYE---WHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFF 630

  Fly   482 TIIITSCYTGSIIAFVTLPAFPDTVDSVLDLL-GLFFRVGTLNNGGWETWFQNSTHIPTSRLYKK 545
            |:||.|.||.::.||:|:......::|..||. ......|||::|..:.:|:.|    ...:|:|
Human   631 TLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRS----KIAVYEK 691

  Fly   546 M----------EFVGSVDEGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFSDE-----NISRRSAL 595
            |          .|..:..||:..|.:| ...:|||......||:.|....|.     |:..:.
Human   692 MWTYMRSAEPSVFTRTTAEGVARVRKS-KGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKG-- 753

  Fly   596 HLSEECFALFQIGFLFPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSN 660
                       .|...|:.|..:..::..:|...::|::.|:.|:  |...:...|.....|...
Human   754 -----------YGVATPKGSSLRTPVNLAVLKLSEAGVLDKLKNK--WWYDKGECGPKDSGSKDK 805

  Fly   661 SLREIIQEERQLTTADTEGMFLLMALGYFLGATALVSEIVGGITNKCRQIIKRSR---KSAASSW 722
            :        ..|:.::..|:|.::..|  ||...||:.|  ....|.|...||.:   ..|..:.
Human   806 T--------SALSLSNVAGVFYILVGG--LGLAMLVALI--EFCYKSRAEAKRMKLTFSEAIRNK 858

  Fly   723 SSASSGSMLRTNAEQLSHDKRKA 745
            :..|....:..|...|:.|..||
Human   859 ARLSITGSVGENGRVLTPDCPKA 881

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.