Protein Alignment Ir21a and GRIA2

DIOPT Version :10

• Sequence 1: NP_001097043.1
• Gene: Ir21a / 33157
• FlyBaseID: FBgn0031209
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: NP_000817.5
• Gene: GRIA2 / 2891
• HGNCID: 4572
• Length: 883
• Species: Homo sapiens
• Alignment Length: 698
• Identity: 138/698 - (19%)
• Similarity: 248/698 - (35%)
• Gaps: 206/698 - (29%)

  Fly   127 GLILENLFKTIPITFYHGEINADYEAKNKRFTSHIDCNCKSYILFLSDPLMTRKILGPQTESRVV 191
            |:.:|...|.:.:....|.|..|...|...:|.:|               |..|..||:
Human   341 GVEIERALKQVQVEGLSGNIKFDQNGKRINYTINI---------------MELKTNGPR------ 384

  Fly   192 LVSRSTQWRLRDFLSSELSSNIVNL--LVIGESLMADPMRERPYVLYTHKLYADGLGSNTPVVLT 254
               :...|       ||:...:|.|  |..|..                   ..||.:.|.||.|
Human   385 ---KIGYW-------SEVDKMVVTLTELPSGND-------------------TSGLENKTVVVTT 420

  Fly   255 SWIKGALSRPHINLFPSKFQFGFAGHRFQISAANQPPFIFRIRTLDSSGMGQLRWDGVEFRLLTM 319
                 .|..|::.:..:        |..                |:    |..|::|....|...
Human   421 -----ILESPYVMMKKN--------HEM----------------LE----GNERYEGYCVDLAAE 452

  Fly   320 ISKRLNFSIDIT-----ETPTRSNTRGVVDTIQEQIIERTVDIGMSGIYIT--QERLMDSA---M 374
            |:|...|...:|     :...|.....:.:.:..:::....||.::.:.||  :|.::|.:   |
Human   453 IAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFM 517

  Fly   375 SVGHSPDCAAFITLASKALPKYRAIMGPFQWPVWVALICVYLGGIFPIVFTDRLTLSHLMGNWGE 439
            |:|.|    ..|....|:.|...:.:.|..:.:|:.::..|: |:..::|        |:..:..
Human   518 SLGIS----IMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYI-GVSVVLF--------LVSRFSP 569

  Fly   440 VENMFWYV-----------------FGMFTNAFSFTGKYSWS----NTRKNSTRLLIGAYWLFTI 483
            .|   |:.                 ||:|.:.:...|.:...    :.|..|.|::.|.:|.||:
Human   570 YE---WHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTL 631

  Fly   484 IITSCYTGSIIAFVTLPAFPDTVDSVLDL-LGLFFRVGTLNNGGWETWFQNSTHIPTSRLYKKME 547
            ||.|.||.::.||:|:......::|..|| .......|||::|..:.:|:.|......:::..|.
Human   632 IIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMR 696

  Fly   548 ------FVGSVDEGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFSDE-----NISRRSALHLSEEC 601
                  ||.:..||:..|.:| ...||:|......||:.|....|.     |:..:.
Human   697 SAEPSVFVRTTAEGVARVRKS-KGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKG-------- 752

  Fly   602 FALFQIGFLFPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLREII 666
                 .|...|:.|..:..::..:|...:.|::.|:.|:  |...:...|    |..|.|.
Human   753 -----YGIATPKGSSLRTPVNLAVLKLSEQGVLDKLKNK--WWYDKGECG----AKDSGSK---- 802

  Fly   667 QEERQLTTADTEGMFLLMALGYFLGATALVSEIVGGITNKCRQIIKRSRKSAASSWSSASSGSML 731
            ::...|:.::..|:|.::..|  ||...||:            :|:...||.|
Human   803 EKTSALSLSNVAGVFYILVGG--LGLAMLVA------------LIEFCYKSRA------------ 841

  Fly   732 RTNAEQLSHDKRKANRREAAEVAQKMSFGMRELNLTRATLREIYGSYG 779
                        :|.|.:.|:.||.::....:.:...||.:|.|..||
Human   842 ------------EAKRMKVAKNAQNINPSSSQNSQNFATYKEGYNVYG 877

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	HisJ	287..>392	CDD:440596	21/114 (18%)
		Lig_chan	405..662	CDD:459656	61/289 (21%)
GRIA2	NP_000817.5	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	16/87 (18%)
		PBP2_iGluR_AMPA	413..794	CDD:270433	89/445 (20%)
		Required for interaction with IQSEC1. /evidence=ECO:0000250|UniProtKB:P19491	867..877		4/9 (44%)