DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir21a and Grin2c

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_036707.3	Gene:	Grin2c / 24411	RGDID:	2739	Length:	1250	Species:	Rattus norvegicus

Alignment Length:	866	Identity:	172/866 - (19%)
Similarity:	294/866 - (33%)	Gaps:	233/866 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YYWVALVLFTA----QAFSIEGDRS---ASYQEKCISRRLINHYQLNKEIFGVGMCDGNNENEFR 60
            |.|.|..:.|:    .|..:||.|:   |||    :|.||::...|.   .|.|   |......|
  Rat   173 YDWSAFAVITSLHPGHALFLEGVRAVADASY----LSWRLLDVLTLE---LGPG---GPRARTQR 227

  Fly    61 QKRRI-VPTFQGN-PRPRGELLASKFHVNSYNFEQTNSLVG-----LVNKIAQEYLNKCPPVIY- 117
            ..|:: .|..... .|...|:|.::        .....|||     ||..:|....: .||..:
  Rat   228 LLRQVDAPVLVAYCSREEAEVLFAE--------AAQAGLVGPGHVWLVPNLALGSTD-APPAAFP 283

  Fly   118 --YDSFVEKS----------DGLILENL--------FKTIPI-----------------TFYHGE 145
              ..|.|.:|          ||:.:..|        :.|:|.                 .||...
  Rat   284 VGLISVVTESWRLSLRQKVRDGVAILALGAHSYRRQYGTLPAPAGDCRSHPGPVSPAREAFYRHL 348

  Fly   146 INADYEAKNKRFTSHIDCNCKSYILFLSDPLMTRKILGPQTESRVVLVSRSTQWRL-----RDFL 205
            :|..:|.::..|:..         .:|..|.|.           |:.::|...|.:     ...|
  Rat   349 LNVTWEGRDFSFSPG---------GYLVRPTMV-----------VIALNRHRLWEMVGRWDHGVL 393

  Fly   206 SSELS-----SNIVNLLVIGESLMADPMRERPYVLYTHKLYADGLGSNTPVVLTSWIKGALSRPH 265
            ..:..     |..:..:|....|....:.|||:|:....  ..|.|...|
  Rat   394 YMKYPVWPRYSTSLQPVVDSRHLTVATLEERPFVIVESP--DPGTGGCVP--------------- 441

  Fly   266 INLFPSKFQFGFAGHRFQISAANQPPFIFRIRTLDSSGMGQLRWDGVEFRLLTMISKRLNFSID- 329
             |..|.:.|   :.|.|  |:.:..|:.            :|...|....:|..::|.:.||.|
  Rat   442 -NTVPCRRQ---SNHTF--SSGDLTPYT------------KLCCKGFCIDILKKLAKVVKFSYDL 488

  Fly   330 --ITETPTRSNTRGVVDTIQEQIIERTVDIGMSGIYITQERLMDSAMSVGHSPDCAAFITLASKA 392
              :|........|||.:.:..::..:..|:.:..:.|.:||......||.......:.:...|..
  Rat   489 YLVTNGKHGKRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIIDFSVPFVETGISVMVSRSNG 553

  Fly   393 LPKYRAIMGPFQWPVWVAL---------ICVYLGGIF-PIVFTDRLTLSHLMGN---------WG 438
            .....|.:.|:...|||.:         |.|::...| |:.:...||.....|.         |
  Rat   554 TVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTKGKKPGGPSFTIGKSVW- 617

  Fly   439 EVENMFWYVFGMFTNAFSFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTGSIIAFVTLPAFP 503
                :.|        |..|.......|.|..::::::..:..|.:|..:.||.::.||:....:.
  Rat   618 ----LLW--------ALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYI 670

  Fly   504 DTVDSVLDLLGLF---------FRVGTLNNGGWETWFQNS-----THIPTSRLYKKMEF-VGSVD 553
            |||..:.|  ..|         ||.||:.||..|...:::     ||:        ::| ..||:
  Rat   671 DTVSGLSD--KKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHM--------VKFNQRSVE 725

  Fly   554 EGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFSDENISRRSALHLSEECFALFQIGFLFPRESVYK 618
            :.:.::.....  .||:...|.|.|:...:...:.::..|.     :.||....|....::|.:|
  Rat   726 DALTSLKMGKL--DAFIYDAAVLNYMAGKDEGCKLVTIGSG-----KVFATTGYGIAMQKDSHWK 783

  Fly   619 IKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLREIIQEERQLTTADTEGMF-- 681
            ..||..:|.....|...|:  |..|          |.....|...|::..  :|...:..|:|
  Rat   784 RAIDLALLQLLGDGETQKL--ETVW----------LSGICQNEKNEVMSS--KLDIDNMAGVFYM 834

  Fly   682 LLMALGYFLGATALVSEIVGGITNKCRQIIKRS---------RKSAASSWSSASS-GSMLRTNAE 736
            ||:|:|..|    ||......:..|.|..:..|         .:...|.::...| .|..|..:.
  Rat   835 LLVAMGLAL----LVFAWEHLVYWKLRHSVPNSSQLDFLLAFSRGIYSCFNGVQSLPSPARPPSP 895

  Fly   737 QLSHDKRKANRREAAEVAQKM 757
            .|:.|..:||..:..:.|:.|
  Rat   896 DLTADSAQANVLKMLQAARDM 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	65/330 (20%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	59/288 (20%)
Grin2c	NP_036707.3	PBP1_iGluR_NMDA_NR2	41..397	CDD:380601	52/262 (20%)
		PBP2_iGluR_NMDA_Nr2	413..813	CDD:270436	93/476 (20%)
		NMDAR2_C	850..>925	CDD:402274	13/67 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900