DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir21a and Grin2b

DIOPT Version :10

Sequence 1:NP_001097043.1 Gene:Ir21a / 33157 FlyBaseID:FBgn0031209 Length:842 Species:Drosophila melanogaster
Sequence 2:NP_036706.1 Gene:Grin2b / 24410 RGDID:2738 Length:1482 Species:Rattus norvegicus


Alignment Length:587 Identity:111/587 - (18%)
Similarity:202/587 - (34%) Gaps:110/587 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   316 LLTMISKRLNFSID---ITETPTRSNTRGVVDTIQEQIIERTVDIGMSGIYITQERLMDSAMSVG 377
            :|..|||.:.|:.|   :|.........|..:.:..:::.:...:.:..:.|.:||......||.
  Rat   464 ILKKISKSVKFTYDLYLVTNGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVP 528

  Fly   378 HSPDCAAFITLASKALPKYRAIMGPFQWPVW----VALICVYLGGIFPIVFTDRLTLSHLMGNWG 438
            ......:.:...|.......|.:.||...||    |.|:.|....:|...:...:..:..:.:..
  Rat   529 FIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGR 593

  Fly   439 E-------VENMFWYVFGMFTNAFSFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTGSIIAF 496
            |       :....|.::|:.     |.......|.:..::::::..:..|.:|..:.||.::.||
  Rat   594 EPGGPSFTIGKAIWLLWGLV-----FNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAF 653

  Fly   497 VTLPAFPDTVDSVLDL-------LGLFFRVGTLNNGGWETWFQNSTHIPTSRLYKKME-FVGSVD 553
            :....:.|.|..:.|.       ....||.||:.||..|...:|:        |.:|. ::|..:
  Rat   654 MIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNN--------YAEMHAYMGKFN 710

  Fly   554 E-GIGNVTQSFFWNY--AFLGSKAQLEYLVQSNFSDENISRRSALHL----SEECFALFQIGFLF 611
            : |:.:...|.....  ||:...|.|.|:.         .|.....|    |.:.||....|...
  Rat   711 QRGVDDALLSLKTGKLDAFIYDAAVLNYMA---------GRDEGCKLVTIGSGKVFASTGYGIAI 766

  Fly   612 PRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLREIIQEERQLTTAD 676
            .::|.:|.::|..||.....|.:.::  |..|          |.....|...|::..  ||...:
  Rat   767 QKDSGWKRQVDLAILQLFGDGEMEEL--EALW----------LTGICHNEKNEVMSS--QLDIDN 817

  Fly   677 TEGMFLLMALGYFLGATALVSEIVGGITNKCRQIIKRSRKSAASSWSSASSGSMLRTN------A 735
            ..|:|      |.|||...:|.    ||..|..:.....:.......|...|.:...:      .
  Rat   818 MAGVF------YMLGAAMALSL----ITFICEHLFYWQFRHCFMGVCSGKPGMVFSISRGIYSCI 872

  Fly   736 EQLSHDKRKANRREAAEVAQKMSFGMRELNLTRATLREIYGSYGAPETDHGQLDIVHTE------ 794
            ..::.::|::...............:..|..|...:..:.|..|:|::   .||.:..|      
  Rat   873 HGVAIEERQSVMNSPTATMNNTHSNILRLLRTAKNMANLSGVNGSPQS---ALDFIRRESSVYDI 934

  Fly   795 ------FPNSSAK-LNNIEDEES---------REALESLQRLDE--FMDQMDNDGNPSS--HTFR 839
                  |.:|..| .||...||:         .....:||..|.  :.|...:...|.|  .|..
  Rat   935 SEHRRSFTHSDCKSYNNPPCEENLFSDYISEVERTFGNLQLKDSNVYQDHYHHHHRPHSIGSTSS 999

  Fly   840 ID 841
            ||
  Rat  1000 ID 1001

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ir21aNP_001097043.1 HisJ 287..>392 CDD:440596 14/78 (18%)
Lig_chan 405..662 CDD:459656 54/282 (19%)
Grin2bNP_036706.1 PBP1_iGluR_NMDA_NR2 33..388 CDD:380601
PBP2_iGluR_NMDA_Nr2 403..803 CDD:270436 70/372 (19%)
Pore-forming. /evidence=ECO:0000269|PubMed:24876489, ECO:0000305|PubMed:24876489 604..623 3/23 (13%)
NMDAR2_C 840..1482 CDD:463148 27/165 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1161..1194
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1269..1301
Interaction with DAPK1. /evidence=ECO:0000250|UniProtKB:Q01097 1292..1304
PDZ-binding 1480..1482
Blue background indicates that the domain is not in the aligned region.

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