Protein Alignment Ir21a and Grin2a

DIOPT Version :10

• Sequence 1: NP_001097043.1
• Gene: Ir21a / 33157
• FlyBaseID: FBgn0031209
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: NP_036705.3
• Gene: Grin2a / 24409
• RGDID: 2737
• Length: 1464
• Species: Rattus norvegicus
• Alignment Length: 791
• Identity: 141/791 - (17%)
• Similarity: 266/791 - (33%)
• Gaps: 214/791 - (27%)

  Fly    65 IVPTF-QGN----PR--PRGELLASKFHVNSYNFE-QTNSLVGLVNKIAQEYLNKCPPVIYYDSF 121
            |||:. .||    |:  |.| |::..:....|:.| :....:|::...|...|.|.       |:
  Rat   256 IVPSLVSGNTELIPKEFPSG-LISVSYDDWDYSLEARVRDGLGILTTAASSMLEKF-------SY 312

  Fly   122 VEKSDGLILENLFK-TIPI-TFYHGEINADYEAKNKRFTSHIDCNCKSYILFLSDPLMTRKILGP 184
            :.::.........| ..|: |.:...:|..::.|:..||..                      |.
  Rat   313 IPEAKASCYGQAEKPETPLHTLHQFMVNVTWDGKDLSFTEE----------------------GY 355

  Fly   185 QTESR--VVLVSRSTQW-------------------RLRDFLSSELSSNIVNLLVIGESLMADPM 228
            |...|  |:::::..:|                   |.:.|...|...|.::::.         :
  Rat   356 QVHPRLVVIVLNKDREWEKVGKWENQTLSLRHAVWPRYKSFSDCEPDDNHLSIVT---------L 411

  Fly   229 RERPYVLYTHKLYADGLGSNTPVVLTSWIKGALSRPHINLFPSKFQFGFAGHRFQISAANQPPFI 293
            .|.|:|:      .:.:...|...:.            |..|.:                  .|:
  Rat   412 EEAPFVI------VEDIDPLTETCVR------------NTVPCR------------------KFV 440

  Fly   294 FRIRTLDSSGMGQLR-WDGVEFRLLTMISKRLNFSIDITETPTRSNTRGVVDT----IQEQIIER 353
             :|....:.||...: ..|....:|..:|:.:.|:.|:.......:.:.|.:.    |.|.:.:|
  Rat   441 -KINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQR 504

  Fly   354 TVDIGMSGIYITQERLMDSAMSVGHSPDCAAFITLASKALPKYRAIMGPFQWPVWVAL------- 411
            .| :.:..:.|.:||......||.......:.:...|.......|.:.||...|||.:
  Rat   505 AV-MAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIV 568

  Fly   412 --ICVYLGGIF-PIVFTDRLT---LSHLMGNWGEVENMFWYVFGMFTNAFSFTGKYSWSNTRKNS 470
              |.|::...| |:.:...|.   ..|  |....:....|.::|:.     |.......|.:..:
  Rat   569 SAIAVFVFEYFSPVGYNRNLAKGKAPH--GPSFTIGKAIWLLWGLV-----FNNSVPVQNPKGTT 626

  Fly   471 TRLLIGAYWLFTIIITSCYTGSIIAFVTLPAFPDTVDSVLDLLGLF---------FRVGTLNNGG 526
            :::::..:..|.:|..:.||.::.||:....|.|.|..:.|  ..|         ||.||:.||.
  Rat   627 SKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSD--KKFQRPHDYSPPFRFGTVPNGS 689

  Fly   527 WETWFQNSTHIPTSRLYKKMEFVGSVDEGIGNV----TQSFFWNYAFLGSKAQLEYLVQSNFSDE 587
            .|...:|  :.|....|........|::.:.::    ..:|.::.|.|..||
  Rat   690 TERNIRN--NYPYMHQYMTRFNQRGVEDALVSLKTGKLDAFIYDAAVLNYKA------------- 739

  Fly   588 NISRRSALHL----SEECFALFQIGFLFPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRS 648
              .|.....|    |...||....|....:.|.:|.:||..:|.....|.:.::  |..|
  Rat   740 --GRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEEL--ETLW----- 795

  Fly   649 SSGRLLQASSSNSLREIIQEERQLTTADTEGMFLLMALGYFLGA-----------------TALV 696
                 |.....|...|::..  ||...:..|:|.::|....|..                 |.:.
  Rat   796 -----LTGICHNEKNEVMSS--QLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLRFCFTGVC 853

  Fly   697 SEIVGGITNKCRQI--------IKRSRKSAASSWSSASSGSM-LRTNAEQLS-----HDKRKANR 747
            |:..|.:.:..|.|        |:..:||...:.:.:.|..: |..:|:.:|     :..|..:.
  Rat   854 SDRPGLLFSISRGIYSCIHGVHIEEKKKSPDFNLTGSQSNMLKLLRSAKNISNMSNMNSSRMDSP 918

  Fly   748 REAAEVAQKMS 758
            :.|.:..|:.|
  Rat   919 KRATDFIQRGS 929

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	HisJ	287..>392	CDD:440596	20/109 (18%)
		Lig_chan	405..662	CDD:459656	57/286 (20%)
Grin2a	NP_036705.3	PBP1_iGluR_NMDA_NR2	32..387	CDD:380601	28/160 (18%)
		PBP2_iGluR_NMDA_Nr2	403..802	CDD:270436	86/483 (18%)
		Pore-forming. /evidence=ECO:0000250|UniProtKB:B7ZSK1	599..620		3/25 (12%)
		NMDAR2_C	839..1464	CDD:463148	16/91 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	989..1083
		PDZ-binding. /evidence=ECO:0000305	1462..1464