DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir21a and Grik5

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	XP_006228444.1	Gene:	Grik5 / 24407	RGDID:	2735	Length:	980	Species:	Rattus norvegicus

Alignment Length:	839	Identity:	177/839 - (21%)
Similarity:	305/839 - (36%)	Gaps:	185/839 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 KCISR--RLINHYQLNKEIFGVGMCDGNNE-----NEFRQKRRIVPTFQGNPRPRGELLASKFHV 86
            :|:.|  .|:..:.::||...|.|.|.:.:     .|.|..:........|        ||..|:
  Rat   169 ECLLRLEELVRGFLISKETLSVRMLDDSRDPTPLLKEIRDDKVSTIIIDAN--------ASISHL 225

  Fly    87 NSYNFEQTNSLVGLVNKIAQEYLNKCP-PVIYYDSFVEKSDGLILENLFKTIPITFYHGEINADY 150
                ..:..|.:|:.:...:..|.... |:::.|..||.|..::..::|.| ...||...:
  Rat   226 ----VLRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFSMFNT-SHPFYPEFV---- 281

  Fly   151 EAKNKRFTSHIDCNCKSYILFLSDPLMTRKILGPQTESRVVLVSRSTQW-RLRDFLSSELSSNIV 214
              ::...:...:|...:|    ..|.::..::   .::..|:||...:. |.::.....|:....
  Rat   282 --RSLNMSWRENCEASTY----PGPALSAALM---FDAVHVVVSAVRELNRSQEIGVKPLACTSA 337

  Fly   215 NLLVIGESLMADPMRERPYVLYTHKLYADGLGSNTPVVLTSWIKGALSRPHINLFPSKFQFG--- 276
            |:...|.||| :.:|...|...|.::..:..|..|...|....|.......|.::.|.....
  Rat   338 NIWPHGTSLM-NYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNA 401

  Fly   277 ----------FAGHRFQISAANQPPFIFRIRTLDSSGMGQLRWDGVEFRLLTMISKRLNFSIDI- 330
                      .|.....::...:.|::.| |....:..|..|::|....:|..:::.|.|...:
  Rat   402 TTLDINLSQTLANKTLVVTTILENPYVMR-RPNFQALSGNERFEGFCVDMLRELAELLRFRYRLR 465

  Fly   331 --------TETPTRSNTRGVVDTIQEQIIERTVDIGMSGIYITQER--LMDSAMSVGHSPDCAAF 385
                    ...|..|.|..|.:.|..|    ..|:.::...||.||  ::|.:         ..|
  Rat   466 LVEDGLYGAPEPNGSWTGMVGELINRQ----KADLAVAAFTITAEREKVIDFS---------KPF 517

  Fly   386 ITLASKAL--------PKYRAIMGPFQWPVWVALICVYLGGIFPIVFTDRLT------------- 429
            :||....|        |.|.:.:.||...||:.::..||.....:....||:
  Rat   518 MTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRA 582

  Fly   430 LSHLMGNWGEVENMFWYVFGMFTNAFSFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTGSII 494
            ..|::.|...:.|..|:..|      .|..:.|....|..|||.:.|.:|.||:||.|.||.::.
  Rat   583 RPHILENQYTLGNSLWFPVG------GFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLA 641

  Fly   495 AFVTLPAFPDTVDSVLDLLG-LFFRVGTLNNGGWETWFQNSTHIPTSRLYKKME------FVGSV 552
            ||:|:......|:|..||.. .....||::.|...|:||||.:....|::..|:      ||.|.
  Rat   642 AFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKST 706

  Fly   553 DEGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFSDENISRRSALHLSEECFALFQIGFL------- 610
            :|||..|..|   .||||......||                 |....| .|.|||.|
  Rat   707 EEGIARVLNS---RYAFLLESTMNEY-----------------HRRLNC-NLTQIGGLLDTKGYG 750

  Fly   611 --FPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRS--SSGRLLQASSSNSLREIIQEERQ 671
              .|..|.::.:|...||..|:       ||.:. :::|.  ..||        ..:|.....:.
  Rat   751 IGMPLGSPFRDEITLAILQLQE-------NNRLE-ILKRKWWEGGR--------CPKEEDHRAKG 799

  Fly   672 LTTADTEGMFLLMALGYFLGATALVSEIVGGITNKCRQIIKRSRKSAASSWSSASSGSMLRTNAE 736
            |...:..|:|:::..|..:.....|.|.:..           :|:||.|     ...|:.:...:
  Rat   800 LGMENIGGIFVVLICGLIIAVFVAVMEFIWS-----------TRRSAES-----EEVSVCQEMLQ 848

  Fly   737 QLSH-------DKRKANRREAAEVAQKMSF-GMRELNLTRATLREI-----YGSYGAPE 782
            :|.|       .:.:..||........:|. .:||:.|:...|...     .|::|.|:
  Rat   849 ELRHAVSCRKTSRSRRRRRPGGPSRALLSLRAVREMRLSNGKLYSAGAGGDAGAHGGPQ 907

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	86/332 (26%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	75/285 (26%)
Grik5	XP_006228444.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616	48/258 (19%)
Grik5	XP_006228444.1	Periplasmic_Binding_Protein_Type_2	414..785	CDD:389745	102/419 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810