Protein Alignment Ir21a and Grin3a

DIOPT Version :9

• Sequence 1: NP_001097043.1
• Gene: Ir21a / 33157
• FlyBaseID: FBgn0031209
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: NP_001263284.1
• Gene: Grin3a / 242443
• MGIID: 1933206
• Length: 1135
• Species: Mus musculus
• Alignment Length: 968
• Identity: 175/968 - (18%)
• Similarity: 307/968 - (31%)
• Gaps: 354/968 - (36%)

  Fly    82 SKFHVNSY-----NFEQTNSLVGLVNKIAQEYLNKCPPVIYY----------------------- 118
            ||||:.|.     |...|..|:..:....:...|..|.::.:
Mouse   287 SKFHLESIINITANLSSTKDLLSFLQVQLENIRNSTPTMVMFGCDMGSIRQIFEMSTQFGLSPPD 351

  Fly   119 ------DS-FVE--KSDGLILENLF--KTIPITF-YHGEINADYEAKNKRFTSHID--------- 162
                  || .||  :::||.|..:.  ||....| |:.:...:..|:.....:.|.
Mouse   352 LHWVLGDSQNVEELRTEGLPLGLIAHGKTTQSVFEYYVQDAMELVARAVATATMIQPELALLPST 416

  Fly   163 CNCKSYILFLSDPLMTRKILGPQTESRVVL------VSRSTQWRLRDFLSSELSSNIVNLLVIGE 221
            .||..        :.|..:...|..||.:.      :|.|.:.:....:|||.:..|.|
Mouse   417 MNCMD--------VKTTNLTSGQYLSRFLANTTFRGLSGSIKVKGSTIVSSENNFFIWN------ 467

  Fly   222 SLMADPMRERPYVLYTHKLYADGLGS--NTPVVLTSWIKGALSRPHINLF--PSKFQFGFAGHRF 282
             |..||| .:|  ::|.      |||  ...:|:.|.|....::.|...|  |:|.       ..
Mouse   468 -LQYDPM-GKP--MWTR------LGSWQGGRIVMDSGIWPEQAQRHKTHFHHPNKL-------HL 515

  Fly   283 QISAANQPPFIFRIRTLDSSGM---GQLRWD-----------------------GVEFR------ 315
            ::....:.||:| .|.:|..|:   |||..|                       .::|:
Mouse   516 RVVTLIEHPFVF-TREVDDEGLCPAGQLCLDPMTNDSSILDSLFSSLHSSNDTVPIKFKKCCYGY 579

  Fly   316 ---LLTMISKRLNFSID------------------------ITETPTRSNTRGVVDTIQEQIIER 353
               ||..:::.:||..|                        ::.|...:.|...::|.:.|:|:.
Mouse   580 CIDLLEQLAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLSGTANMAVTSFSINTARSQVIDF 644

  Fly   354 TVDIGMS--GIYITQERLMDSAMSVGHSPDCAAFITLASKALPKYRAIMGPFQWPVWVAL-ICVY 415
            |.....:  ||.:   |..|:|..:|                    |.|.|..|.:|:.: :.::
Mouse   645 TSPFFSTSLGILV---RTRDTAAPIG--------------------AFMWPLHWTMWLGIFVALH 686

  Fly   416 LGGIFPIVFTDRLTLSHLMGNWGEVENMFWYVFGMF------TNAFSFTGKYS------------ 462
            :..||       |||.    .|..       .|||.      ...|||:...:
Mouse   687 ITAIF-------LTLY----EWKS-------PFGMTPKGRNRNKVFSFSSALNVCYALLFGRTAA 733

  Fly   463 ------WSNTRKNSTRLLIGAYWLFTIIITSCYTGSIIAFVTLPAFPDTVDSVLD------LLGL 515
                  |:.      |.|:..:.:|.:...|.||.::.|.:......:.:..:.|      ..|
Mouse   734 IKPPKCWTG------RFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQG- 791

  Fly   516 FFRVGTLNNGGWETWFQNSTHIPTSRLYKKMEFVGSVDEGIGNVTQSFFWNYAFLGSKAQLEYLV 580
             ||.||:.....|.:.:.|  .|....|.:...|.:..:|:..:........||:..||.|:|.|
Mouse   792 -FRFGTVRESSAEDYVRQS--FPEMHEYMRRYNVPATPDGVQYLKNDPEKLDAFIMDKALLDYEV 853

  Fly   581 QSNFSDENISRRSALHLSEEC--------FALFQIGFLFPRESVYKIKIDSMILLAQQSGLIAKI 637
            .               :..:|        ||:...|...|..|.....|..:|...:..|.:..:
Mouse   854 S---------------IDADCKLLTVGKPFAIEGYGIGLPPNSPLTSNISELISQYKSHGFMDVL 903

  Fly   638 NNEVSWVM-----QRSSSGRLLQASSSNSLREIIQEERQLTTADTEGMFLLMALGYFLGATALVS 697
            :::  |..     :||.:               :.|..|:......|:|:|:.:|:.|.....:.
Mouse   904 HDK--WYKVVPCGKRSFA---------------VTETLQMGIKHFSGLFVLLCIGFGLSILTTIG 951

  Fly   698 E------IVGGITNK---------------------------CRQIIKRSRKSAASSWSSASSG- 728
            |      ::..|.||                           |.: .||..||....|:..:.|
Mouse   952 EHIVYRLLLPRIKNKSKLQYWLHTSQRFHRALNTSFVEEKQPCSK-TKRVEKSRWRRWTCKTEGD 1015

  Fly   729 --------------SMLRTNAEQLSHDKRKA---NRRE-----AAEVAQKMSFGMRELNLTRATL 771
                          .::..|...||||.::.   |..|     ..:..|.:....|.
Mouse  1016 SELSLFPRSNMGPQQLMVWNTSNLSHDNQRKYIFNDEEGQNQLGTQTHQDIPLPPRR-------- 1072

  Fly   772 REIYGSYGAPETDHGQLDIVHTEFPNSSAKLNNIED------EESREALESLQRLDEF 823
            ||:..|.    |.:|:.|.::....:...:|:.:|.      :|.:.|:.....|:|:
Mouse  1073 RELPASL----TTNGKADSLNVARNSVMQELSELEKQIQVIRQELQLAVSRKTELEEY 1126

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	72/385 (19%)
		Lig_chan	407..662	CDD:278489	52/298 (17%)
Grin3a	NP_001263284.1	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	48/233 (21%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	82/471 (17%)
		Lig_chan	676..942	CDD:278489	57/325 (18%)
		PPP2CB binding site. /evidence=ECO:0000250|UniProtKB:Q9R1M7	951..987		4/35 (11%)
		GIT1-binding. /evidence=ECO:0000250|UniProtKB:Q9R1M7	1082..1115		5/32 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900