DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir21a and Grin3a

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_612555.1	Gene:	Grin3a / 191573	RGDID:	621704	Length:	1135	Species:	Rattus norvegicus

Alignment Length:	967	Identity:	175/967 - (18%)
Similarity:	305/967 - (31%)	Gaps:	352/967 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 SKFHVNSY-----NFEQTNSLVGLVNKIAQEYLNKCPPVIYY----DSF---------------- 121
            ||||:.|.     |...|..|:..:........|..|.::.:    ||.
  Rat   287 SKFHLESVINITANLSSTKDLLSFLQVQMDNIRNSTPTMVMFGCDMDSIRQIFEMSTQFGLSPPE 351

  Fly   122 ----------VE--KSDGLILENLF--KTIPITF-YHGEINADYEAKNKRFTSHID--------- 162
                      ||  :::||.|..:.  ||....| |:.:...:..|:.....:.|.
  Rat   352 LHWVLGDSQNVEELRTEGLPLGLIAHGKTTQSVFEYYVQDAMELVARAVATATMIQPELALLPST 416

  Fly   163 CNCKSYILFLSDPLMTRKILGPQTESRVVL------VSRSTQWRLRDFLSSELSSNIVNLLVIGE 221
            .||..        :.|..:...|..||.:.      :|.|.:.:....:|||.:..|.|
  Rat   417 MNCMD--------VKTTNLTSGQYLSRFLANTTFRGLSGSIKVKGSTIISSENNFFIWN------ 467

  Fly   222 SLMADPMRERPYVLYTHKLYADGLGS--NTPVVLTSWIKGALSRPHINLF--PSKFQFGFAGHRF 282
             |..||| .:|  ::|.      |||  ...:|:.|.|....::.|...|  |:|.       ..
  Rat   468 -LQHDPM-GKP--MWTR------LGSWQGGRIVMDSGIWPEQAQRHKTHFQHPNKL-------HL 515

  Fly   283 QISAANQPPFIFRIRTLDSSGM---GQLRWD-----------------------GVEFR------ 315
            ::....:.||:| .|.:|..|:   |||..|                       .::|:
  Rat   516 RVVTLIEHPFVF-TREVDDEGLCPAGQLCLDPMTNDSSMLDRLFSSLHSSNDTVPIKFKKCCYGY 579

  Fly   316 ---LLTMISKRLNFSID------------------------ITETPTRSNTRGVVDTIQEQIIER 353
               ||..:::.:||..|                        ::.|...:.|...::|.:.|:|:.
  Rat   580 CIDLLEQLAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLSGTANMAVTSFSINTARSQVIDF 644

  Fly   354 TVDIGMS--GIYITQERLMDSAMSVGHSPDCAAFITLASKALPKYRAIMGPFQWPVWVAL-ICVY 415
            |.....:  ||.:   |..|:|..:|                    |.|.|..|.:|:.: :.::
  Rat   645 TSPFFSTSLGILV---RTRDTAAPIG--------------------AFMWPLHWTMWLGIFVALH 686

  Fly   416 LGGIFPIVFTDRLTLSHLMGNWGEVENMFWYVFGMF------TNAFSFTGKYS------------ 462
            :..||       |||.    .|..       .|||.      ...|||:...:
  Rat   687 ITAIF-------LTLY----EWKS-------PFGMTPKGRNRNKVFSFSSALNVCYALLFGRTAA 733

  Fly   463 ------WSNTRKNSTRLLIGAYWLFTIIITSCYTGSIIAFVTLPAFPDTVDSVLD------LLGL 515
                  |:.      |.|:..:.:|.:...|.||.::.|.:......:.:..:.|      ..|
  Rat   734 IKPPKCWTG------RFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQG- 791

  Fly   516 FFRVGTLNNGGWETWFQNSTHIPTSRLYKKMEFVGSVDEGIGNVTQSFFWNYAFLGSKAQLEYLV 580
             ||.||:.....|.:.:.|  .|....|.:...|.:..:|:..:........||:..||.|:|.|
  Rat   792 -FRFGTVRESSAEDYVRQS--FPEMHEYMRRYNVPATPDGVQYLKNDPEKLDAFIMDKALLDYEV 853

  Fly   581 QSNFSDENISRRSALHLSEEC--------FALFQIGFLFPRESVYKIKIDSMILLAQQSGLIAKI 637
            .               :..:|        ||:...|...|..|.....|..:|...:..|.:..:
  Rat   854 S---------------IDADCKLLTVGKPFAIEGYGIGLPPNSPLTSNISELISQYKSHGFMDVL 903

  Fly   638 NNEVSWVM-----QRSSSGRLLQASSSNSLREIIQEERQLTTADTEGMFLLMALGYFLGATALVS 697
            :::  |..     :||.:               :.|..|:......|:|:|:.:|:.|.....:.
  Rat   904 HDK--WYKVVPCGKRSFA---------------VTETLQMGIKHFSGLFVLLCIGFGLSILTTIG 951

  Fly   698 E------IVGGITNKC--------------------------RQIIKRSRKSAASSWSSASSG-- 728
            |      ::..|.||.                          |...||..||....|:..:.|
  Rat   952 EHIVHRLLLPRIKNKSKLQYWLHTSQRFHRALNTSFVEEKQPRSKTKRVEKSRWRRWTCKTEGDS 1016

  Fly   729 -------------SMLRTNAEQLSHDKRKA---NRRE-----AAEVAQKMSFGMRELNLTRATLR 772
                         .::..|...||||.::.   |..|     ..:..|.:....|.        |
  Rat  1017 ELSLFPRSNLGPQQLMVWNTSNLSHDNQRKYIFNDEEGQNQLGTQAHQDIPLPQRR--------R 1073

  Fly   773 EIYGSYGAPETDHGQLDIVHTEFPNSSAKLNNIED------EESREALESLQRLDEF 823
            |:..|.    |.:|:.|.::....:...:|:.:|.      :|.:.|:.....|:|:
  Rat  1074 ELPASL----TTNGKADSLNVTRSSVIQELSELEKQIQVIRQELQLAVSRKTELEEY 1126

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	72/385 (19%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	52/298 (17%)
Grin3a	NP_612555.1	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	48/233 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..117
		ANF_receptor	127..469	CDD:279440	36/196 (18%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	82/471 (17%)
		Lig_chan	676..942	CDD:278489	57/325 (18%)
		PPP2CB binding site	951..987		4/35 (11%)
		GIT1-binding. /evidence=ECO:0000269\|PubMed:24297929	1082..1115		5/32 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900