DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir21a and glr-6

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_741822.2	Gene:	glr-6 / 180955	WormBaseID:	WBGene00001617	Length:	844	Species:	Caenorhabditis elegans

Alignment Length:	662	Identity:	138/662 - (20%)
Similarity:	251/662 - (37%)	Gaps:	147/662 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 NSLVGLVNKIAQEYLNKCP--PVIYYDSFVEKSDGLILENLFKTIPITFYHGEINADYEAKNKRF 157
            |.|...:..:.||||.|.|  |...:..|....|.::|.                  .:|.::|.
Worm   274 NDLAIKLPDMYQEYLAKIPSNPRTPFKDFAFIFDSILLA------------------CQAGDRRI 320

  Fly   158 TSHIDCN----CKSYILFLSDPL--MTRKILGPQTESRVVLVSRSTQWRLRDFLSSELSSNIVNL 216
               |.|.    .|.:.|.:..|.  :|.||....|..|                 |:...:|..:
Worm   321 ---ISCGDNEAVKKFKLPIVKPFKGLTGKISFNGTSDR-----------------SDSELHIWEM 365

  Fly   217 LVIGESLMADPMRERPYVLYTHKLYADGLGSNTPVVLTSWIKGALSRPHINLFPSKFQFGFAGHR 281
            .:.|..            |:|....:...||....:|...|.|.......::..|:        .
Worm   366 GITGAG------------LHTGIWKSTWEGSKELTMLAKNIPGTHEHYQASVRESR--------T 410

  Fly   282 FQISAANQPPFIFRIRTLDSSGMGQLRWDGVEFRLLTMISKRLNFSIDI-----TETPTRSNTRG 341
            .::::.::.|::......|    |:::.:|....||..:::.|:|:..:     .:...|.|...
Worm   411 LKVTSIHEKPYVIEKIMPD----GRIKHEGFCVDLLDKLAEMLHFNYTLKIVKDNKYGERKNGTD 471

  Fly   342 VVDTIQEQIIERTVDIGMSGIYITQERL-----MDSAMSVGHSPDCAAFITLASKALPKYRAIMG 401
            ..|.:..:|:....|:.::.|.:|..||     .|..:.:|.|       .|..:..||..:.:.
Worm   472 EWDGMIGEILRGDADMAVAPITVTATRLEVIDFTDPFLQLGIS-------MLMRQPNPKSSSSLT 529

  Fly   402 PFQWP----VW----VALICVYLGGIFPIVFTDRLTLSHLMGNWGEVENMFWYVFGMFTNAFSFT 458
            .|.||    ||    :|.:...|......|.:.:.:.:..     :::|..||:..:...|
Worm   530 RFLWPLSASVWTFSAIATVITALLVTVAAVLSPKESTAEF-----KIQNSVWYLVCILLRA---- 585

  Fly   459 GKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTGSIIAFVTLPAFPDTVDSVLDLLG--LFFRVGT 521
              .|..|.:..:|||:...:|.||:::.:.||.:..|.:|:.......:| .:.||  ..:..|:
Worm   586 --GSGYNCQAGATRLISAVWWSFTLVLIAQYTANFAALLTVDRKSMPFNS-FEELGNQTEYNFGS 647

  Fly   522 LNNGGWETWFQNSTHIPTSRLYKKME------FVGSVDEGIGNVTQSFFWNYAFLGSKAQLEYLV 580
            :..|....:|:.|......||:::|:      |||:..||:..|...   .|.||...|.|:|.|
Worm   648 ILGGSTMQFFKYSRIETFRRLWERMQSAEPSAFVGTNHEGVNRVLNE---KYVFLMESATLDYQV 709

  Fly   581 QSNFSDENISRRSALHLSEECFALFQIGFLFPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVM 645
            ..|.   |::|...:.|....:::     ..|:.|.::.|:...||...:.|:|..:.|  :|
Worm   710 TQNC---NLTRVGNVVLGSNGYSI-----ALPKGSKWREKLTRQILDLNEKGIILMLKN--NW-- 762

  Fly   646 QRSSSGRLLQASSSNSLREIIQEERQLTTADTEGMFLLMALGYFLGATALVSEIV---------- 700
             ...|.:..|:|....|:..:..|      :..|:|||:|||..:|....|.|..
Worm   763 -WKKSQQECQSSEPEDLQTALGAE------NVYGLFLLLALGSGIGVLCAVLEHTHFIFFEKNKR 820

  Fly   701 GGITNKCRQIIK 712
            .|.|.|.:|:|:
Worm   821 NGQTPKLQQMIE 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	70/319 (22%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	60/266 (23%)
glr-6	NP_741822.2	PBP1_iGluR_non_NMDA-like	21..394	CDD:380591	32/169 (19%)
glr-6	NP_741822.2	PBP2_iGluR_Kainate	409..764	CDD:270432	83/401 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010