DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir21a and glr-8

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_001368711.1	Gene:	glr-8 / 180924	WormBaseID:	WBGene00001619	Length:	547	Species:	Caenorhabditis elegans

Alignment Length:	572	Identity:	118/572 - (20%)
Similarity:	194/572 - (33%)	Gaps:	149/572 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   287 ANQPPFIFRIRTLDSSGMGQLRWDGVEFRLLTMISKRLNFSIDITETPTRSNTRGVVDTIQE--- 348
            |.:||::..:...|::...:....||...:|..|.||||.:.:|  .|...:|.|      |
Worm    70 AIEPPYVNYVNFSDAAVTDKGYGPGVVMEILKEIGKRLNLTYEI--LPALGSTWG------EYLN 126

  Fly   349 --------QIIERTVDIGMSGIYITQER--LMDSAMSVGHSPDCAAFITLASKALPKYR-----A 398
                    |::...||:...|..:..:|  :.|........|     ..:..::..||.     .
Worm   127 GSWTGAFGQLVRGEVDLLAGGAIMEYDRSVIADLTYPFQFEP-----TGIMIRSPEKYEDDTLLI 186

  Fly   399 IMGPFQWPVWVALICVYL-GGIFPIVFT-------DRLTLSHLMGNWGEVENMFWYVFGMFTNAF 455
            :..||.|.|||....|.| .|:..:|.|       :.:|::..        ...|..|.:|....
Worm   187 VTEPFSWEVWVITAAVILISGVIFLVMTNIIRKVYEEMTVTPF--------ESIWVFFSIFVQQG 243

  Fly   456 SFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTGSIIAF-----VTLPAFPDTVDSVLDLL-- 513
            ......||      |.|:|:..:||.:|.:::.:|||::|.     ..:|.  ..:|.::.|:
Worm   244 LPEQPRSW------SCRVLVALWWLASITLSATFTGSLVALFAVDKTNVPF--QNIDQLVRLVKQ 300

  Fly   514 GLFFRVGTLNNGGWETWFQNSTHIPTSRL--YK----------KMEFVGSVDEGIGNVTQSFFWN 566
            |.|..|...|:      |..:..|..|:|  |:          |:::|..:..|:..|..:  ..
Worm   301 GKFEIVMDENS------FTRTEMIARSKLPVYRDLWHEMIVNHKVKYVNGIARGVAFVRAN--PG 357

  Fly   567 YAFLGSKAQLEYLVQSNFSDENISRRSALHLSEEC-FALFQIGFL-------FPRESVYKIKIDS 623
            ||.||..|.|.:...|                 :| ..||..|.|       ..:.|:|.....:
Worm   358 YALLGPMATLNFYAYS-----------------DCKVILFNDGILPVYLSIPLVKNSIYSPYFST 405

  Fly   624 MILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLREIIQEERQLTTADTEGMFLLMALGY 688
            .|....:.|...|      |:....|...:.:.:..||  ..|..:..|.....:|.|.:...|.
Worm   406 KIREMVERGFTQK------WIADYRSYVAMQKINECNS--TTIGPKSYLDLKRAQGAFWVFLGGA 462

  Fly   689 FLGATALVSEIVGGITNKCRQIIKRSRKSAASSWSSASSGSMLRTNAEQLSHDKRKANRREAAEV 753
            .||....|.|.          |.|..|:                   :...|.|......|.|.|
Worm   463 GLGLALFVGEF----------IFKFFRE-------------------KMTKHTKTTTVPPEVATV 498

  Fly   754 AQKMSFGMRELNLTRATLREIYGSYGAPETDHGQLDIVHTEFPNSSAKLNNI 805
            :..::.....|::.    .|:..|...|..| |...:......|.|..|:||
Worm   499 SANVAENSTSLDIP----DEVLPSAPLPSED-GNWSLRRRNILNLSLDLSNI 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	74/338 (22%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	60/289 (21%)
glr-8	NP_001368711.1	PBP2_iGluR_ligand_binding	62..424	CDD:270219	87/413 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810