DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir21a and glr-7

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_001337310.1	Gene:	glr-7 / 180547	WormBaseID:	WBGene00001618	Length:	885	Species:	Caenorhabditis elegans

Alignment Length:	788	Identity:	153/788 - (19%)
Similarity:	269/788 - (34%)	Gaps:	224/788 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 QAFSIEGDRSASYQEKCISRRLINHYQLNKEIFGVGMCDGNNENEFRQKRRIVPTFQGNPRPRGE 78
            :.|::|   :|.:    |.:|:.|.|.|.|:|... .|| :.|:.|        .|...|.|.|:
Worm   178 ERFTLE---AADF----IEQRVFNTYVLTKDITAF-KCD-SCESAF--------MFWLRPFPVGK 225

  Fly    79 LLASKFHVNSYNFEQTNSLVGLVNKIAQEYLNKCPPVIYYDSFVEKSDGLILE---NLFKTIPIT 140
            |:..: .::.|.|.         |:|                      ||.|:   |.:.::.:.
Worm   226 LMEIR-DLDDYLFR---------NEI----------------------GLELDYSINGWDSLNVA 258

  Fly   141 FYHGEINADYE---AKNKRFTSHIDCNCKSYILFLSDPLMTRKILGPQTESRVVLVSRSTQWRLR 202
            ||...:...:|   ..|..|.......|::               ||...:....|        |
Worm   259 FYMNVMGYAFETIRTMNATFDVLPTFTCQT---------------GPSEPNITTTV--------R 300

  Fly   203 DFLSSELSSNIVNLLVIGESLMADPMRERPYVLYTHKLYADGL-----GSNTPVVLTSWIKGALS 262
            |.:.::.:....|....|.::....:..|.|.:...:.:.|.|     |..:|:...|.:.|.|.
Worm   301 DIILNDPAHEYGNYTEAGLNMFFQDVEVRIYKIDRDRDHEDALFNKEVGVWSPISKLSVMYGTLQ 365

  Fly   263 RPHINLFPSKFQFGFAGHRFQISAANQPPFIFRIRTLDSSGMGQLRWDGVEFRLLTMISKRLNFS 327
            ....||           :.|::....||||:.|      :|.....::|....|:.||...:||:
Worm   366 VDVRNL-----------NIFRVVTLIQPPFVQR------TGDPDTPYEGYCIDLINMIQVEVNFT 413

  Fly   328 IDITETPTRS--------NTRGVVDTIQEQIIERTVDIGMSGIYITQERLMDSAMSVGHSPDCAA 384
            ..|.|....|        |..|::..    ::..:.||.::.:.:..||..|...:|.:. |...
Worm   414 YTIYEVEDGSFGTMDDNGNWNGLIGA----LVSGSADIALAPLSVMAERENDVDFTVPYY-DLVG 473

  Fly   385 FITLASKALPKYR--AIMGPFQWPVWVALICVYLGGIFPIVFTDRLTLSHLMGNWGEVEN----- 442
            ...|..||..:|.  ..|...:||||:.::..||.....:...||.:......|....:|
Worm   474 TTILMKKADVEYSLFKFMKVLEWPVWLCIVAAYLFTSILLWIFDRFSPYSFTNNKERYQNDIEKR 538

  Fly   443 ------MFWYVFGMFTNAFSFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTGSIIAFVTLPA 501
                  ..|:..      .|.|.:......:..|.||:...:|||..||.:.||.::.||:|:..
Worm   539 QFSLKECLWFCM------TSLTPQGGGEAPKNISGRLVAATWWLFGFIIIASYTANLAAFLTVSR 597

  Fly   502 FPDTVDSVLDLLGLF-FRVGTLNNGGWETWFQNSTHIPTS--RLYKKMEFVGSVDEGIG------ 557
            ....:.|:.||...: .....:.....||:|:....|..:  .::|:|    |::|.:.
Worm   598 LEQPISSLDDLAKQYKIEYAPIKGSASETYFRRMAEIEETFYNMWKEM----SLNESMSPRDRAK 658

  Fly   558 ------NVTQSF--FWNY------------------------AFLGSKAQLEYLVQSNFSDENIS 590
                  .|:..|  .|.|                        ||:|...:::|...:|.:
Worm   659 LAVWDYPVSDKFTNMWRYMQESKLPVNMDTAVDRVLNSVDGFAFIGDATEIKYAALTNCN----- 718

  Fly   591 RRSALHLSEECFALFQIGFLFPRE---------SVYKIKIDSMILLAQQSGLIAKINNEVSWVMQ 646
                         |.|:|..|.|:         .:.|.||.|.||:......:..: .|..|.
Worm   719 -------------LQQVGTEFSRKPYAIAVQSGHILKDKISSAILMLLNERRLETL-KEKWWT-- 767

  Fly   647 RSSSGRLLQASSSNSLREIIQEERQLTTADTEGMFLLMALGYFLGATALVSEIVGGITNKCRQII 711
             .:..::....||:       |...::..:..|:|:::..|..|....|..|.         ...
Worm   768 -DNPNKVSCPDSSD-------ESDGISIQNIGGVFIVILAGIALSIVTLAFEY---------YYY 815

  Fly   712 KRSRKSAA 719
            ||..:.||
Worm   816 KRKARKAA 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	74/355 (21%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	59/315 (19%)
glr-7	NP_001337310.1	Periplasmic_Binding_Protein_Type_1	<102..>220	CDD:324556	15/58 (26%)
glr-7	NP_001337310.1	PBP2_iGluR_putative	373..767	CDD:270435	88/433 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810