DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir21a and nmr-2

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_001256640.1	Gene:	nmr-2 / 180002	WormBaseID:	WBGene00003775	Length:	990	Species:	Caenorhabditis elegans

Alignment Length:	942	Identity:	172/942 - (18%)
Similarity:	310/942 - (32%)	Gaps:	308/942 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SYYWVALVLFTAQ--AFSIEGDRS----------ASYQEKCISRRLINHYQLNKEIFGVGMCDGN 54
            ||..:.::.:.|.  .|:.|.|..          ..:|.:.: ..|:..|...|  |||
Worm   144 SYTGIPIIAWNADNAGFTFENDLGPYRIIQMAPPIEHQARAM-LALLRRYNWPK--FGV------ 199

  Fly    55 NENEFRQKRRIVPTFQGNPR----PRGEL-----LASKFHVNSYNFEQTNSLVGLVNKIAQEYLN 110
                      :.....||.|    .|.||     .::||.:..::...|.:...:..|:|....|
Worm   200 ----------VTSEMAGNDRFVTAIREELELFSNKSTKFEMIHFSHMNTKNDTDVDLKLADVKKN 254

  Fly   111 KCPPVIYYD---------SFVEKSD---------------------------GLILENLFKTIPI 139
            :...::.|.         |..||.|                           |::..|
Worm   255 QAKIILLYANAAQAGTIFSHAEKMDMIGEKYLWIGTQSVKGTQTTVKAPAQAGMLCVN------- 312

  Fly   140 TFYHGEINADYEAK------------------------NKRFTSHIDCNCKSYILFLSDPLMTR- 179
              :|...||.:..:                        |:.|:...:.:|||..   .||....
Worm   313 --FHTVSNAMFAPRDDILPLIIQLAPKLFGAALLQLRPNEMFSLKSNVSCKSED---GDPYWDNG 372

  Fly   180 KILGPQTESRVVLVSRSTQWRLRD-----FLSSELSSNIVNLLVIGESLMADPMRERPYV---LY 236
            |.:....::..|   :...:.:.|     |.:.|.:..:.|.::...:|..:...|:.:.   ::
Worm   373 KYIYEHMKAAFV---KGNPFHVDDGHDSFFYTFEKTGRLRNSILQISNLRTNSKGEKTWEKVGIF 434

  Fly   237 THK--LYAD----GLGSNTPVVLTSWIKGALSRPHINLFPSKFQFGFAGHRFQISAANQPPFIFR 295
            |:.  ..||    |..:|.|       :||..:.|:                ::...::|||| .
Worm   435 TNNELKMADVQWPGEKANPP-------QGAADKFHV----------------KVVTLHEPPFI-A 475

  Fly   296 IRTLD------SSGMGQL-RWDGVEFR---------------------LLTMISKRLNFSIDITE 332
            :..:|      ....|.: .|..||:.                     ||..::..:.|:..:.:
Worm   476 VSDVDPDTQKCPGNQGSICDWGDVEYTDGAGVKKNRTLLKCCSGYCVDLLNKLANDIGFTYTLYK 540

  Fly   333 T-------PTRSNTRGVVDTIQEQIIERTVDIGMSGIYITQERLMDSAMSVGHSPDCAAFITLAS 390
            .       .|.:...|::    ..::....|:.::.:.:..||..|...|:       .|:....
Worm   541 VRDEKWGLKTENGWNGLI----ADLMHNKADMCVTSLKLNSERARDIDFSL-------PFLDTGI 594

  Fly   391 KALPKYR-------AIMGPFQWPVWVAL--ICVYLGGIFPIVFTDRLTLSHLMGNWGEVENMF-- 444
            ..:.|.|       |.:.||::..||.:  :|:::..|...:|......|..|..:...|:.|
Worm   595 SIIVKIRSGVLSPTAFLEPFEYSTWVIILFVCIHVAAISIFLFEWVSPYSFNMQKYPPPEHKFSL 659

  Fly   445 ----WYVFGMFTNAFSFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTGSIIAFVTLPAFPDT 505
                |.|:     |..|:...|....:...:||:...:..|.:...:.||.::.||:.      |
Worm   660 FRSYWLVW-----ATLFSASVSTDVPKSTVSRLMALVWAAFGLTFLAVYTANLAAFMI------T 713

  Fly   506 VDSVLDLLGLF-------------FRVGTLNNGGWETWFQNSTHIPTSRLYKKM-EFVG------ 550
            .....||.|:.             ||.||::.|        :||....|.:.|| |:|.
Worm   714 RVQYYDLSGIHDPMLNFPHDQKPPFRFGTVDGG--------NTHETMKRNWHKMHEYVKHNKYFR 770

  Fly   551 -SVDEGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFSDENISRRSALHLSEECFALFQIGFLFPRE 614
             ::..||..|.....  .||:.....|:|...   .|.|    .||....:..::...|..||:.
Worm   771 MNISAGIEAVKNEEL--DAFIYDAVVLDYWAG---KDAN----CALMTVGKWASMTGYGIGFPKN 826

  Fly   615 SVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLREIIQEERQLTTADTEG 679
            |.:...::..:|..||.|.:.::.|  .|:     :|.....|.|.:....:..|..|:.
Worm   827 SPHTSLVNHYMLQYQQKGDLERLQN--FWL-----TGACTPDSHSQTQSAPLGIENFLSA----- 879

  Fly   680 MFLLMALGYFLGATALVSEIVGGITN-KCRQIIKRSRKSAASSWS---SASSG------------ 728
             |:|:|.|      .:||.||.|..: .|..:.|..:|...:.|.   |.:.|
Worm   880 -FVLLAGG------IIVSVIVLGFEHIYCMHLRKPLQKIDPNGWCGIISMAMGKSLTFTEAVDRV 937

  Fly   729 --------SMLRTNAEQLSHDKRKANRREAAE 752
                    |:..||:.||.. :|.||.|...|
Worm   938 QEWRSRTQSLASTNSPQLKR-RRSANLRPTEE 968

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	69/364 (19%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	61/283 (22%)
nmr-2	NP_001256640.1	rSAM_ocin_1	<54..>108	CDD:274893
		Periplasmic_Binding_Protein_type1	102..443	CDD:385651	51/332 (15%)
		Periplasmic_Binding_Protein_Type_2	460..860	CDD:389745	85/462 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910