Protein Alignment Ir21a and glr-5

DIOPT Version :10

• Sequence 1: NP_001097043.1
• Gene: Ir21a / 33157
• FlyBaseID: FBgn0031209
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: NP_505244.1
• Gene: glr-5 / 179251
• WormBaseID: WBGene00001616
• Length: 932
• Species: Caenorhabditis elegans
• Alignment Length: 755
• Identity: 144/755 - (19%)
• Similarity: 253/755 - (33%)
• Gaps: 256/755 - (33%)

  Fly    24 ASYQEKCISRRLINHYQLNKEIFGVGMCDGNNENEFRQKRRIVPTFQGNPRP--RGELLASKFHV 86
            |.|....:...|.:|.|:|.....:......|..:::..|.::.....|...  .|:|.....|.
 Worm   319 AVYAFANVFNELSSHMQMNDVPQTLCRKSSRNSRKYQHGRSLIDNIVHNDLHGLSGDLRRLNGHP 383

  Fly    87 NSYNFEQTNSLVGLVNKIAQEYLNKCPPVIYYDSFVEKSDGLILENLFKTIPITFYHGEINADYE 151
            ...||.....|:|        |..:...:.:::                  |.|..|..::.|.:
 Worm   384 LKSNFSMRIQLLG--------YSGRLDDIGFWE------------------PATNVHVNMSGDSK 422

  Fly   152 AKNKRFTSHIDCNCKSYILFLSDPLMTRKILGPQTESRVVLVSRSTQWRLRDFLSSELSSNIVNL 216
            |:                                       :.|:.|      :|.||..:
 Worm   423 AQ---------------------------------------LQRNVQ------VSDELKPH---- 438

  Fly   217 LVIGESLMADPMRERPYVLYTHKLYADGLGSNTPVVLTSWIKGALSRPHINL-FPSKFQFGFA-- 278
                  .....:.|||||:                         |.:.|..| ..|||: ||.
 Worm   439 ------FRVTTIMERPYVM-------------------------LKKNHYELDANSKFE-GFCID 471

  Fly   279 ---------GHRFQISAANQPPFIFRIRTLDSSGMGQLRWDGVEFRLLTMISKRLNFSIDITETP 334
                     |..:.|.|.....:     ..|..|.|.  |||       |:.:.|....::...|
 Worm   472 LLAELSKDLGFTYTIHAVKDGKY-----GNDKYGNGS--WDG-------MMGEILRGEAEMAVAP 522

  Fly   335 TRSNTRGVVDTIQEQIIERT---VDIGMSGIYITQERLMDSAMSVGHSPDCAAFITLASKALPKY 396
            ...|.|      :.:.::.|   :.:|:|.:|    ::.|.     ..||..:|
 Worm   523 LTVNYR------RSEAVDFTKPFLSLGISILY----KVPDD-----QQPDLFSF----------- 561

  Fly   397 RAIMGPFQWPVWVA----LICVYLGGIF---------------------------------PIVF 424
               :.|..|.:|.|    :|.|.||..|                                 |||.
 Worm   562 ---LNPLSWQIWTAIATSIITVTLGMYFVANVTPYEWNLNFSCCTAHEPHPAAAFATNQEAPIVM 623

  Fly   425 TDRLTLSHLMGNWGEVENMFWYVFG-MFTNAFSFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSC 488
            ::..:.      |    |..|||.. |......|       ..|..|||||.|.:|:|.::|.|.
 Worm   624 SNNYSF------W----NTVWYVLSTMLKGGCDF-------GPRAVSTRLLGGTWWVFYLVIISA 671

  Fly   489 YTGSIIAFVTL--PAFP-DTVDSVLDLLGLFFRVGTLNNGGWETWFQNSTHIPTSRLYKKME--- 547
            ||.::.|.:|:  |..| ..:|.:.:...:.:  ||:..|....:||.|......::::.|:
 Worm   672 YTANLAAVLTVSRPYIPIKNLDDLANQTTISY--GTIRGGSTMQFFQESRIAAHVKMWQYMKDKD 734

  Fly   548 -FVGSVDEGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFSDENISRRSALHLSEECFALFQIGFLF 611
             ||.|..:|   |.::...|||:|.....|||..|.|.   |:::...: |..:.:     |...
 Worm   735 VFVTSNGKG---VERALSMNYAYLMESTSLEYETQQNC---NLTQIGGV-LGSKGY-----GIAL 787

  Fly   612 PRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLREIIQEERQLTTAD 676
            .::|.:..:|...|||..:.|:|.         |:::...|...|:.:::...:..:...|:..:
 Worm   788 AKKSEWTDRISRQILLYAKRGIIE---------MKKTKWWRSKGAACASTASAVKHDRFALSMYN 843

  Fly   677 TEGMFLLMALGYFLGATALVSEIVGGITNKCRQIIKRSRK 716
            ..|:|:.:.:|..|.|..::.|::    ::|..|.|:..|
 Worm   844 VAGLFITLGVGIVLAAIVVIFELI----HRCHHIAKKEGK 879

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	HisJ	287..>392	CDD:440596	19/107 (18%)
		Lig_chan	405..662	CDD:459656	70/301 (23%)
glr-5	NP_505244.1	PBP1_iGluR_non_NMDA-like	26..417	CDD:380591	20/123 (16%)
		PBP2_iGluR_Kainate	438..819	CDD:270432	104/499 (21%)
		Lig_chan	566..854	CDD:459656	73/327 (22%)