DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir21a and glr-1

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_498887.2	Gene:	glr-1 / 176204	WormBaseID:	WBGene00001612	Length:	962	Species:	Caenorhabditis elegans

Alignment Length:	722	Identity:	162/722 - (22%)
Similarity:	263/722 - (36%)	Gaps:	196/722 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 QEYLNKCPPVIYYDSFVEKSDGLILENLF---KTIPITFYH-----------GEINADYEAKNKR 156
            :.:.|:..|.||.|...::|......:.|   |||.:.|.:           |.|..|.....|.
Worm   344 RRFFNRGFPGIYCDPLSDRSHPNRPFSSFEHGKTIGVAFRNMKIGHKEGTLTGNIEFDRFGNRKN 408

  Fly   157 F-TSHIDCNCKSYILFLS-DPLMTRKILGPQTESRVVLVSRSTQWRLRDFLSSELSSNIVNLLVI 219
            | .|.:|....:...|.| :.|..|:.:|..:...|...||.:|...:|           |.:::
Worm   409 FDVSIVDLVSNTKATFNSKEVLAWRQGVGFFSNRTVAQHSRKSQNDHKD-----------NQVIV 462

  Fly   220 GESLMADPMRERPYVLYTHKL-----YADGLGSNTPVVLTSWIKGALSRPHINLFPSKFQFGFAG 279
            ..:|:|      |:|:...:.     ..:..|:|                       ||: ||..
Worm   463 LTNLVA------PFVMIKRECLEMANLTECQGNN-----------------------KFE-GFCI 497

  Fly   280 HRFQISAANQPPFIFRIRTLDSSGMGQL--RWDGVEFRLLTMISKRLNFSIDITETPTRSNTRGV 342
            ...::.|.....|.:.|:....:|..|.  .|||:...||:..:..:..|:.|.
Worm   498 DLLKLLADKIEEFNYEIKLGTKAGSKQADGSWDGMIGELLSGRAHAVVASLTIN----------- 551

  Fly   343 VDTIQEQIIERTVDIGMSGIYITQERLMDSAMSVG-HSPDCAAFITLASKALPKYRAIMGPFQWP 406
                ||:  ||.||.        .:..|.:.:|:. ..||...|...         :.|.|....
Worm   552 ----QER--ERVVDF--------SKPFMTTGISIMIKKPDKQEFSVF---------SFMQPLSTE 593

  Fly   407 VWVALICVYLGGIFPIVF--------------TDR--LTLSHLMGNWGEVENMFWYVFGMF---- 451
            :|:.:|..|: |:..::|              |.|  .|:|    |...|.|..|:....|
Worm   594 IWMYIIFAYI-GVSVVIFLVSRFSPYEWRVEETSRGGFTIS----NDFSVYNCLWFTLAAFMQQG 653

  Fly   452 TNAFSFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTGSIIAFVTLPAFPDTVDSVLDLLGLF 516
            |:..          .|..|.|:...|:|.||:||.|.||.::.||:||......::||.||....
Worm   654 TDIL----------PRSISGRIASSAWWFFTMIIVSSYTANLAAFLTLEKMQAPIESVEDLAKQS 708

  Fly   517 -FRVGTLNNGGWETWFQNSTHIPTSRLYKKME------FVGSVDEGIGNVTQSFFWNYAFLGSKA 574
             .:.|....|...::|:.|:.....|:::.||      ||.|..|||..| :|....||||....
Worm   709 KIKYGIQGGGSTASFFKYSSVQIYQRMWRYMESQVPPVFVASYAEGIERV-RSHKGRYAFLLEAT 772

  Fly   575 QLEYLVQSNFSDENISR-----RSALHLSEECFALFQIGFLFPRESVYKIKIDSMILLAQQSGLI 634
            ..||        ||..:     :...:|:.     ...|...|..|.:|..|:..||..|:.|.:
Worm   773 ANEY--------ENTRKPCDTMKVGANLNS-----IGYGIATPFGSDWKDHINLAILALQERGEL 824

  Fly   635 AKINNEVSWVMQRS--SSGRLLQASSSNSLREIIQEERQLTTADTEGMF----------LLMALG 687
            .|:.|:  |...|.  .:|..:..||::           |..:...|:|          :|.|||
Worm   825 KKLENK--WWYDRGQCDAGITVDGSSAS-----------LNLSKVAGIFYILMGGMVISMLAALG 876

  Fly   688 YFLGATALVSEIVGGITNKCRQIIKRSRKSAASSW--SSASSGSMLRTNAEQLSHDKRK------ 744
            .||..:.:  |.....:|.......::.|||.||.  .|...|::.:..::..:..:|:
Worm   877 EFLYRSRI--EARKSNSNSMVANFAKNLKSALSSQLRLSVEGGAVAQPGSQSHNAIRRQQVAAFL 939

  Fly   745 -ANRREA 750
             ||.:||
Worm   940 PANEKEA 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	80/323 (25%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	75/288 (26%)
glr-1	NP_498887.2	PBP1_iGluR_AMPA	10..439	CDD:107375	23/94 (24%)
		ANF_receptor	44..417	CDD:279440	18/72 (25%)
		Periplasmic_Binding_Protein_Type_2	457..832	CDD:304360	107/480 (22%)
		Lig_chan	593..867	CDD:278489	78/315 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910