Protein Alignment Ir21a and glr-3

DIOPT Version :10

• Sequence 1: NP_001097043.1
• Gene: Ir21a / 33157
• FlyBaseID: FBgn0031209
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: NP_492017.3
• Gene: glr-3 / 172449
• WormBaseID: WBGene00001614
• Length: 836
• Species: Caenorhabditis elegans
• Alignment Length: 622
• Identity: 129/622 - (20%)
• Similarity: 221/622 - (35%)
• Gaps: 187/622 - (30%)

  Fly   124 KSDGLILENLFKTIPITFYHGEINADYEAKNKRFTSHIDCNCKSYILFLSDPLMTRKILGPQTES 188
            ||...|.:..|:. |:....|:::.....:...:|.|:.....|:..|......||:|    ..|
 Worm   325 KSGSDIKKRFFEN-PLAGISGDLHWAPSGERSNYTLHVYRRTLSFQKFAEWSSRTRRI----ASS 384

  Fly   189 RVVLVSRSTQWRLRDFLSSELSSNIVNLLVIGESLMADPMRERPYVLYTHKLYADGLGSNTPVVL 253
            ..|:::.|::                .|.:.|:.|......|.|:|:.|         ||
 Worm   385 EAVVIANSSE----------------KLTLEGKHLKISVYLEAPFVMIT---------SN----- 419

  Fly   254 TSWIKGALSRPHINLFPSKFQFGFAGHRFQISAANQPPFIFRIRTLDSSGMGQL----RWDGVEF 314
                 |:.....|:|.          |:.    ||...|.:.|:.:..:..|..    :|.|:..
 Worm   420 -----GSYEGYCIDLL----------HKI----ANILKFTYTIQKVRDNAYGSKESNGKWSGMVG 465

  Fly   315 RL------LTMISKRLNFSIDITETPTRSNTRGVVDTIQEQIIERTV---DIGMSGIYITQERLM 370
            .|      |.:.|..:::.                   :.::|:.||   .:|:| |...:.|:.
 Worm   466 ELQRGDADLAVASLTISYG-------------------RSEVIDFTVPYMHLGIS-ILFKKPRIR 510

  Fly   371 DSAMSVGHSPDCAAFITLASKALPKYRAIMGPFQWPVWVALICVY---------LGGIFPIVFTD 426
            ||        |...|              |.|....||:.....|         :..|.|.   :
 Worm   511 DS--------DWFKF--------------MDPLSTQVWIMTFASYFVVSVAIWIIAKISPY---E 550

  Fly   427 RLTLSHLMGNWGEVENMFWYVFGMFTNAFSFT-----GKYSWSNTRKNSTRLLIGAYWLFTIIIT 486
            :.......|.:..|:|.|     ...|:|.||     .:.|....|..|||||.|.:|.|.:|:.
 Worm   551 QFERDEDNGQYKPVDNQF-----SLRNSFWFTVCSLMQQGSELCPRAASTRLLTGIWWFFALILI 610

  Fly   487 SCYTGSIIAFVTLPAFPDTVDSVLDLLG-LFFRVGTLNNGGWETWFQNSTHIPTSRLYKKME--- 547
            |.||.::.|.:|.......:::..||.. ...:.|||..|...::|..|......|:::.|.
 Worm   611 SSYTANLAAVLTTRRMETPIENADDLAAQTKIKYGTLGRGSTMSFFNESKIETYERMWQLMSSSP 675

  Fly   548 --FVGSVDEGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFSDENISRRSALHLSEECFALFQIGFL 610
              ||.|..|||..|..|   :||:|...:.|||.|:                 .:| .|.|||.|
 Worm   676 GLFVQSSKEGIARVKSS---DYAYLMESSMLEYAVE-----------------RDC-ELMQIGGL 719

  Fly   611 ---------FPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLREII 666
                     .|:.|.|:..|.:.||..|:...:.::..:  |...:|               .:.
 Worm   720 IDQKGYGIGLPKGSPYRELISTAILRLQEKTELTELKEK--WWKDKS---------------VVC 767

  Fly   667 QEERQLTTADTE---GMFLLMALGYFLGATALVSEIV 700
            ::.::....|.|   |:|:::.:|..|.|..::.|::
 Worm   768 EQPKRKDQDDGESIGGIFIILVVGLVLTAVLVIFELI 804

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	HisJ	287..>392	CDD:440596	21/117 (18%)
		Lig_chan	405..662	CDD:459656	69/285 (24%)
glr-3	NP_492017.3	PBP1_iGluR_non_NMDA-like	21..385	CDD:380591	13/64 (20%)
		Periplasmic_Binding_Protein_Type_2	401..761	CDD:473866	102/465 (22%)