Protein Alignment Ir21a and Grin3b

DIOPT Version :10

• Sequence 1: NP_001097043.1
• Gene: Ir21a / 33157
• FlyBaseID: FBgn0031209
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: XP_006513350.1
• Gene: Grin3b / 170483
• MGIID: 2150393
• Length: 1138
• Species: Mus musculus
• Alignment Length: 593
• Identity: 113/593 - (19%)
• Similarity: 183/593 - (30%)
• Gaps: 163/593 - (27%)

  Fly   194 SRSTQWRLRDFLSSELSSNIVNLLVIGESLMADPMRERPYVLYTHKLYADGLGSNTPVVLTSWIK 258
            |.||...|..|||:.........:.:..|......|.    .....|..|.||:.....:.||..
Mouse   411 SESTARTLARFLSNTSFQGRTGAVWVAGSSQVHVSRH----FKVWSLRRDPLGAPAWATVGSWQD 471

  Fly   259 GALSRPHINLFPSKFQFGFAGHRFQISAANQP------------PFIFRIRTLDSSGM---GQLR 308
            |.|.          ||.|.|..|....:..|.            ||:| .|..|..|.   |||.
Mouse   472 GQLD----------FQPGAAALRVPSPSGTQARPKLRVVTLVEHPFVF-TRESDEDGQCPAGQLC 525

  Fly   309 WD------------------------------GVEFRLLTMISKRLNFSID-------------- 329
            .|                              |....||..:::.|.|..:
Mouse   526 LDPGTNDSARLDALFTALENGSVPRTLRRCCYGYCIDLLERLAEDLAFDFELYIVGDGKYGALRD 590

  Fly   330 ----------ITETPTRSNTRGVVDTIQEQIIERTVDIGMSGIYITQERLMDSAMSVGHSPDCAA 384
                      :......:.|...:::.:.|:::.|.....:.:.| ..|..|:|..:|
Mouse   591 GRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGI-MVRTRDTASPIG------- 647

  Fly   385 FITLASKALPKYRAIMGPFQWPVWVALI-CVYLGGIFPIVFTDRLTLSHLMGNWGEVE------N 442
                         |.|.|..|.:||.:. .::|..:|       |||......:|...      .
Mouse   648 -------------AFMWPLHWSMWVGVFAALHLTALF-------LTLYEWRSPYGLTPRGRNRGT 692

  Fly   443 MFWYVFGMFTNAFSFTGKYSWSNTRKNST-RLLIGAYWLFTIIITSCYTGSIIAFV----TLPAF 502
            :|.|...:........|:...|.|.|..| |.|:..:.:|.:::.|.||.::.|.:    |....
Mouse   693 VFSYSSALNLCYAILFGRTVSSKTPKCPTGRFLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEEL 757

  Fly   503 PDTVDSVLDLLGLFFRVGTLNNGGWETWFQNSTHIPTSRLYKKMEFVGSVDEGIGNVTQSFFWNY 567
            ....|..|......||.||:.....|.:.:.|  .|....:.:.....:...|:..:|.......
Mouse   758 SGIHDPKLHHPSQGFRFGTVWESSAEAYIKAS--FPEMHAHMRRHSAPTTPHGVAMLTSDPPKLN 820

  Fly   568 AFLGSKAQLEYLVQSNFSDENISRRSALHLSEEC--------FALFQIGFLFPRESVYKIKIDSM 624
            ||:..|:.|:|.|.               :..:|        ||:...|...|:.|.....:...
Mouse   821 AFIMDKSLLDYEVS---------------IDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEF 870

  Fly   625 ILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLREIIQEERQLTTADTEGMFLLMALGYF 689
            |...:.||.|..::::  |........|:.          .:.|..|:......|:|:|:.||
Mouse   871 ISRYKSSGFIDLLHDK--WYKMVPCGKRVF----------AVTETLQMGVYHLSGLFVLLCLG-- 921

  Fly   690 LGATALVS 697
            ||:..|.|
Mouse   922 LGSALLTS 929

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	HisJ	287..>392	CDD:440596	24/173 (14%)
		Lig_chan	405..662	CDD:459656	53/276 (19%)
Grin3b	XP_006513350.1	PBP1_iGluR_NMDA_NR3	141..481	CDD:380600	20/83 (24%)
		PBP2_iGluR_NMDA_Nr3	494..888	CDD:270438	77/441 (17%)
		Lig_chan	654..921	CDD:459656	58/302 (19%)