Protein Alignment Ir21a and Grin2d

DIOPT Version :10

• Sequence 1: NP_001097043.1
• Gene: Ir21a / 33157
• FlyBaseID: FBgn0031209
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: XP_036008580.1
• Gene: Grin2d / 14814
• MGIID: 95823
• Length: 1345
• Species: Mus musculus
• Alignment Length: 616
• Identity: 119/616 - (19%)
• Similarity: 220/616 - (35%)
• Gaps: 155/616 - (25%)

  Fly   179 RKILGPQTESRVVLVSRSTQWRLRDF-LSSELSSN--IVNLLVIGESLMADPMRERPYVLYTHKL 240
            |..|..:..:.|.:|:|..|..|||: ...||..:  ..|....||||....|.    :.:.::.
Mouse   315 RDDLARRVAAGVAVVARGAQALLRDYGFLPELGHDCRAQNRTHRGESLHRYFMN----ITWDNRD 375

  Fly   241 YA---DGLGSNTPVVLTS------W-IKGALSRPHINL-FPSKFQFGFAGHRF----------QI 284
            |:   ||...|..:|:.|      | :.|:..:..:.| :|...::|    ||          .:
Mouse   376 YSFNEDGFLVNPSLVVISLTRDRTWEVVGSWEQQTLRLKYPLWSRYG----RFLQPVDDTQHLTV 436

  Fly   285 SAANQPPFIFRIRTLDSSGMGQLRWDGVEFR---------------------------------L 316
            :...:.||:. :...|......:| |.|..|                                 :
Mouse   437 ATLEERPFVI-VEPADPISGTCIR-DSVPCRSQLNRTHSLVAPRSPPPDAPRPEKRCCKGFCIDI 499

  Fly   317 LTMISKRLNFSID---ITETPTRSNTRGVVDTIQEQIIERTVDIGMSGIYITQER---------L 369
            |..::..:.||.|   :|.........||.:.:..::..:..|:.:..:.|.:||         .
Mouse   500 LKRLAHTIGFSYDLYLVTNGKHGKKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPF 564

  Fly   370 MDSAMSV-------GHSPDC-AAFITLASKALPKYRAIMGPFQWPVWVAL--ICVYLGGIFPIVF 424
            :::.:||       ..||.. .||..|.....|:      |:...|||.:  :|:.:..:...:|
Mouse   565 VETGISVMVARSNGTVSPSAFLAFAWLMPPMSPE------PYSPAVWVMMFVMCLTVVAVTVFIF 623

  Fly   425 ---------TDRLTLSHLMGNWGEVENMFWYVFGMFTNAFSFTGKYSWSNTRKNSTRLLIGAYWL 480
                     ....|.....|:...:....|.::     |..|.......|.|..::::::..:..
Mouse   624 EYLSPVGYNRSLATGKRPGGSTFTIGKSIWLLW-----ALVFNNSVPVENPRGTTSKIMVLVWAF 683

  Fly   481 FTIIITSCYTGSIIAFVTLPAFPDTVDSVLDLLGLF---------FRVGTLNNGGWETWFQNSTH 536
            |.:|..:.||.::.||:....:.|||..:.|  ..|         .:.||:.||..|...:  ::
Mouse   684 FAVIFLASYTANLAAFMIQEEYVDTVSGLSD--RKFQRPQEQYPPLKFGTVPNGSTEKNIR--SN 744

  Fly   537 IPTSRLYKKMEFVGSVDEGI-----GNVTQSFFWNYAFLGSKAQLEYLVQSNFSDENISRRSALH 596
            .|....|........|:|.:     |.:.       ||:...|.|.|:.:.:...:.::..|.
Mouse   745 YPDMHSYMVRYNQPRVEEALTQLKAGKLD-------AFIYDAAVLNYMARKDEGCKLVTIGSG-- 800

  Fly   597 LSEECFALFQIGFLFPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNS 661
               :.||....|....:.|.:|..||  :.|.|..|     ::|:..:.:...||     ...|.
Mouse   801 ---KVFATTGYGIALHKGSRWKRPID--LALLQFLG-----DDEIEMLERLWLSG-----ICHND 850

  Fly   662 LREIIQEERQLTTADTEGMF--LLMALGYFL 690
            ..|::..  :|...:..|:|  ||:|:|..|
Mouse   851 KIEVMSS--KLDIDNMAGVFYMLLVAMGLSL 879

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	HisJ	287..>392	CDD:440596	25/157 (16%)
		Lig_chan	405..662	CDD:459656	53/281 (19%)
Grin2d	XP_036008580.1	Periplasmic_Binding_Protein_type1	<156..415	CDD:471960	26/103 (25%)
		PBP2_iGluR_NMDA_Nr2	432..849	CDD:270436	79/457 (17%)