Protein Alignment Ir21a and Grin2c

DIOPT Version :10

• Sequence 1: NP_001097043.1
• Gene: Ir21a / 33157
• FlyBaseID: FBgn0031209
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: XP_017169765.1
• Gene: Grin2c / 14813
• MGIID: 95822
• Length: 1307
• Species: Mus musculus
• Alignment Length: 788
• Identity: 157/788 - (19%)
• Similarity: 267/788 - (33%)
• Gaps: 211/788 - (26%)

  Fly     3 YYWVALVLFTA----QAFSIEGDRS---ASYQEKCISRRLINHYQLNKEIFGVGMCDGNNENEFR 60
            |.|.|..:.|:    .|..:||.|:   |||    :|.||::...|.   .|.|   |......|
Mouse   222 YDWSAFAVITSLHPGHALFLEGVRAVADASY----LSWRLLDVLTLE---LGPG---GPRARTQR 276

  Fly    61 QKRRI-VPTFQGN-PRPRGELLASKFHVNSYNFEQTNSLVG-----LVNKIAQEYLNKCPPVIY- 117
            ..|:: .|..... .|...|:|.::        .....|||     ||..:|....: .||..:
Mouse   277 LLRQVDAPVLVAYCSREEAEVLFAE--------AAQAGLVGPGHVWLVPNLALGSTD-APPAAFP 332

  Fly   118 --YDSFVEKS----------DGLILENL--------FKTIPI-----------------TFYHGE 145
              ..|.|.:|          ||:.:..|        :.|:|.                 .||...
Mouse   333 VGLISVVTESWRLSLRQKVRDGVAILALGAHSYRRQYGTLPAPAGDCRSHPGPVSPAREAFYRHL 397

  Fly   146 INADYEAKNKRFTSHIDCNCKSYILFLSDPLMTRKILGPQTESRVVLVSRSTQWRL-----RDFL 205
            :|..:|.::..|:..         .:|..|.|.           |:.::|...|.:     ...|
Mouse   398 LNVTWEGRDFSFSPG---------GYLVQPTMV-----------VIALNRHRLWEMVGRWDHGVL 442

  Fly   206 SSELS-----SNIVNLLVIGESLMADPMRERPYVLYTHKLYADGLGSNTPVVLTSWIKGALSRPH 265
            ..:..     |..:..:|....|....:.|||:|:....  ..|.|...|
Mouse   443 YMKYPVWPRYSTSLQPVVDSRHLTVATLEERPFVIVESP--DPGTGGCVP--------------- 490

  Fly   266 INLFPSKFQFGFAGHRFQISAANQPPFIFRIRTLDSSGMGQLRWDGVEFRLLTMISKRLNFSID- 329
             |..|.:.|   :.|.|  |:.:..|:.            :|...|....:|..::|.:.||.|
Mouse   491 -NTVPCRRQ---SNHTF--SSGDITPYT------------KLCCKGFCIDILKKLAKVVKFSYDL 537

  Fly   330 --ITETPTRSNTRGVVDTIQEQIIERTVDIGMSGIYITQERLMDSAMSVGHSPDCAAFITLASKA 392
              :|........|||.:.:..::..:..|:.:..:.|.:||......||.......:.:...|..
Mouse   538 YLVTNGKHGKRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIIDFSVPFVETGISVMVARSNG 602

  Fly   393 LPKYRAIMGPFQWPVWVAL---------ICVYLGGIF-PIVFTDRLTLSHLMGN---------WG 438
            .....|.:.|:...|||.:         |.|::...| |:.:...||.....|.         |
Mouse   603 TVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTKGKKSGGPSFTIGKSVW- 666

  Fly   439 EVENMFWYVFGMFTNAFSFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTGSIIAFVTLPAFP 503
                :.|        |..|.......|.|..::::::..:..|.:|..:.||.::.||:....:.
Mouse   667 ----LLW--------ALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYI 719

  Fly   504 DTVDSVLDLLGLF---------FRVGTLNNGGWETWFQNS-----THIPTSRLYKKMEFVGSVDE 554
            |||..:.|  ..|         ||.||:.||..|...:::     ||:.........:.:.|:..
Mouse   720 DTVSGLSD--KKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSLKM 782

  Fly   555 GIGNVTQSFFWNYAFLGSKAQLEYLVQSNFSDENISRRSALHLSEECFALFQIGFLFPRESVYKI 619
            |..:|::..   .||:...|.|.|:...:...:.::..|.     :.||....|....::|.:|.
Mouse   783 GARHVSRKL---DAFIYDAAVLNYMAGKDEGCKLVTIGSG-----KVFATTGYGIAMQKDSHWKR 839

  Fly   620 KIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLREIIQEERQLTTADTEGMF--L 682
            .||..:|.....|...|:  |..|          |.....|...|::..  :|...:..|:|  |
Mouse   840 AIDLALLQFLGDGETQKL--ETVW----------LSGICHNEKNEVMSS--KLDIDNMAGVFYML 890

  Fly   683 LMALGYFL 690
            |:|:|..|
Mouse   891 LVAMGLAL 898

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	HisJ	287..>392	CDD:440596	19/107 (18%)
		Lig_chan	405..662	CDD:459656	59/289 (20%)
Grin2c	XP_017169765.1	PBP1_iGluR_NMDA_NR2	90..446	CDD:380601	52/262 (20%)
		PBP2_iGluR_NMDA_Nr2	462..868	CDD:270436	93/475 (20%)
		NMDAR2_C	905..>980	CDD:463148