Protein Alignment Ir21a and Grin2b

DIOPT Version :10

• Sequence 1: NP_001097043.1
• Gene: Ir21a / 33157
• FlyBaseID: FBgn0031209
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: NP_032197.3
• Gene: Grin2b / 14812
• MGIID: 95821
• Length: 1482
• Species: Mus musculus
• Alignment Length: 587
• Identity: 111/587 - (18%)
• Similarity: 202/587 - (34%)
• Gaps: 110/587 - (18%)

  Fly   316 LLTMISKRLNFSID---ITETPTRSNTRGVVDTIQEQIIERTVDIGMSGIYITQERLMDSAMSVG 377
            :|..|||.:.|:.|   :|.........|..:.:..:::.:...:.:..:.|.:||......||.
Mouse   464 ILKKISKSVKFTYDLYLVTNGKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVP 528

  Fly   378 HSPDCAAFITLASKALPKYRAIMGPFQWPVW----VALICVYLGGIFPIVFTDRLTLSHLMGNWG 438
            ......:.:...|.......|.:.||...||    |.|:.|....:|...:...:..:..:.:..
Mouse   529 FIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGR 593

  Fly   439 E-------VENMFWYVFGMFTNAFSFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTGSIIAF 496
            |       :....|.::|:.     |.......|.:..::::::..:..|.:|..:.||.::.||
Mouse   594 EPGGPSFTIGKAIWLLWGLV-----FNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAF 653

  Fly   497 VTLPAFPDTVDSVLDL-------LGLFFRVGTLNNGGWETWFQNSTHIPTSRLYKKME-FVGSVD 553
            :....:.|.|..:.|.       ....||.||:.||..|...:|:        |.:|. ::|..:
Mouse   654 MIQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNN--------YAEMHAYMGKFN 710

  Fly   554 E-GIGNVTQSFFWNY--AFLGSKAQLEYLVQSNFSDENISRRSALHL----SEECFALFQIGFLF 611
            : |:.:...|.....  ||:...|.|.|:.         .|.....|    |.:.||....|...
Mouse   711 QRGVDDALLSLKTGKLDAFIYDAAVLNYMA---------GRDEGCKLVTIGSGKVFASTGYGIAI 766

  Fly   612 PRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLREIIQEERQLTTAD 676
            .::|.:|.::|..||.....|.:.::  |..|          |.....|...|::..  ||...:
Mouse   767 QKDSGWKRQVDLAILQLFGDGEMEEL--EALW----------LTGICHNEKNEVMSS--QLDIDN 817

  Fly   677 TEGMFLLMALGYFLGATALVSEIVGGITNKCRQIIKRSRKSAASSWSSASSGSMLRTN------A 735
            ..|:|      |.|||...:|.    ||..|..:.....:.......|...|.:...:      .
Mouse   818 MAGVF------YMLGAAMALSL----ITFICEHLFYWQFRHCFMGVCSGKPGMVFSISRGIYSCI 872

  Fly   736 EQLSHDKRKANRREAAEVAQKMSFGMRELNLTRATLREIYGSYGAPETDHGQLDIVHTE------ 794
            ..::.::|::...............:..|..|...:..:.|..|:|::   .||.:..|
Mouse   873 HGVAIEERQSVMNSPTATMNNTHSNILRLLRTAKNMANLSGVNGSPQS---ALDFIRRESSVYDI 934

  Fly   795 ------FPNSSAK-LNNIEDEES---------REALESLQRLDE--FMDQMDNDGNPSS--HTFR 839
                  |.:|..| .||...||:         .....:||..|.  :.|...:...|.|  .|..
Mouse   935 SEHRRSFTHSDCKSYNNPPCEENLFSDYISEVERTFGNLQLKDSNVYQDHYHHHHRPHSIGSTSS 999

  Fly   840 ID 841
            ||
Mouse  1000 ID 1001

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	HisJ	287..>392	CDD:440596	14/78 (18%)
		Lig_chan	405..662	CDD:459656	54/282 (19%)
Grin2b	NP_032197.3	PBP1_iGluR_NMDA_NR2	33..388	CDD:380601
		PBP2_iGluR_NMDA_Nr2	403..803	CDD:270436	70/372 (19%)
		NMDAR2_C	840..1482	CDD:463148	27/165 (16%)