Protein Alignment Ir21a and Grik5

DIOPT Version :10

• Sequence 1: NP_001097043.1
• Gene: Ir21a / 33157
• FlyBaseID: FBgn0031209
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: XP_030098003.1
• Gene: Grik5 / 14809
• MGIID: 95818
• Length: 1003
• Species: Mus musculus
• Alignment Length: 850
• Identity: 177/850 - (20%)
• Similarity: 309/850 - (36%)
• Gaps: 184/850 - (21%)

  Fly    29 KCISR--RLINHYQLNKEIFGVGMCDGNNE-----NEFRQKRRIVPTFQGNPRPRGELLASKFHV 86
            :|:.|  .|:..:.::||...|.|.|.:.:     .|.|..:........|......:|....::
Mouse   169 ECLLRLEELVRGFLISKETLSVRMLDDSRDPTPLLKEIRDDKVSTIIIDANASISHLVLRLSLNL 233

  Fly    87 NS-YNFEQTNSL----------VGLVNKIAQEYLNKCP-PVIYYDSFVEKSDGLILENLFKTIPI 139
            :| ..|.::..|          :|:.:...:..|.... |:::.|..||.|..::..::|.| ..
Mouse   234 SSPLGFPRSLPLGLSCVLQASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFSMFNT-SH 297

  Fly   140 TFYHGEINADYEAKNKRFTSHIDCNCKSYILFLSDPLMTRKILGPQTESRVVLVSRSTQW-RLRD 203
            .||...:      ::...:...:|...:|    ..|.::..::   .::..|:||...:. |.::
Mouse   298 PFYPEFV------RSLNMSWRENCEASTY----PGPALSAALM---FDAVHVVVSAVRELNRSQE 349

  Fly   204 FLSSELSSNIVNLLVIGESLMADPMRERPYVLYTHKLYADGLGSNTPVVLTSWIKGALSRPHINL 268
            .....|:....|:...|.||| :.:|...|...|.::..:..|..|...|....|.......|.:
Mouse   350 IGVKPLACTSANIWPHGTSLM-NYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKSRQGHREIGV 413

  Fly   269 FPSKFQFG-------------FAGHRFQISAANQPPFIFRIRTLDSSGMGQLRWDGVEFRLLTMI 320
            :.|.....             .|.....::...:.|::.| |....:..|..|::|....:|..:
Mouse   414 WYSNRTLAMNATTLDINLSQTLANKTLVVTTILENPYVMR-RPNFQALSGNERFEGFCVDMLREL 477

  Fly   321 SKRLNFSIDI---------TETPTRSNTRGVVDTIQEQIIERTVDIGMSGIYITQER--LMDSAM 374
            ::.|.|...:         ...|..|.|..|.:.|..|    ..|:.::...||.||  ::|.:
Mouse   478 AELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRQ----KADLAVAAFTITAEREKVIDFS- 537

  Fly   375 SVGHSPDCAAFITLASKAL--------PKYRAIMGPFQWPVWVALICVYLGGIFPIVFTDRLT-- 429
                    ..|:||....|        |.|.:.:.||...||:.::..||.....:....||:
Mouse   538 --------KPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPY 594

  Fly   430 -----------LSHLMGNWGEVENMFWYVFGMFTNAFSFTGKYSWSNTRKNSTRLLIGAYWLFTI 483
                       ..|::.|...:.|..|:..|      .|..:.|....|..|||.:.|.:|.||:
Mouse   595 EWYNPHPCLRARPHILENQYTLGNSLWFPVG------GFMQQGSEIMPRALSTRCVSGVWWAFTL 653

  Fly   484 IITSCYTGSIIAFVTLPAFPDTVDSVLDLLG-LFFRVGTLNNGGWETWFQNSTHIPTSRLYKKME 547
            ||.|.||.::.||:|:......|:|..||.. .....||::.|...|:||||.:....|::..|:
Mouse   654 IIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQ 718

  Fly   548 ------FVGSVDEGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFSDENISRRSALHLSEECFALFQ 606
                  ||.|.:|||..|..|   .||||......||                 |....| .|.|
Mouse   719 SKQPSVFVKSTEEGIARVLNS---RYAFLLESTMNEY-----------------HRRLNC-NLTQ 762

  Fly   607 IGFL---------FPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRS--SSGRLLQASSSN 660
            ||.|         .|..|.::.:|...||..|:       ||.:. :::|.  ..||
Mouse   763 IGGLLDTKGYGIGMPLGSPFRDEITLAILQLQE-------NNRLE-ILKRKWWEGGR-------- 811

  Fly   661 SLREIIQEERQLTTADTEGMFLLMALGYFLGATALVSEIVGGITNKCRQIIKRSRKSAASSWSSA 725
            ..:|.....:.|...:..|:|:::..|..:.....|.|.:..           :|:||.|
Mouse   812 CPKEEDHRAKGLGMENIGGIFVVLICGLIIAVFVAVMEFIWS-----------TRRSAES----- 860

  Fly   726 SSGSMLRTNAEQLSH-------DKRKANRREAAEVAQKMSF-GMRELNLTRATLREI-----YGS 777
            ...|:.:...::|.|       .:.:..||........:|. .:||:.|:...|...     .|:
Mouse   861 EEVSVCQEMLQELRHAVSCRKTSRSRRRRRPGGPSRALLSLRAVREMRLSNGKLYSAGAGGDAGA 925

  Fly   778 YGAPE 782
            :|.|:
Mouse   926 HGGPQ 930

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	HisJ	287..>392	CDD:440596	24/115 (21%)
		Lig_chan	405..662	CDD:459656	75/287 (26%)
Grik5	XP_030098003.1	PBP1_iGluR_Kainate_KA1_2	23..424	CDD:380616	48/269 (18%)
		Periplasmic_Binding_Protein_Type_2	437..808	CDD:473866	102/419 (24%)