DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir21a and Grik3

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_001074566.1	Gene:	Grik3 / 14807	MGIID:	95816	Length:	919	Species:	Mus musculus

Alignment Length:	522	Identity:	115/522 - (22%)
Similarity:	199/522 - (38%)	Gaps:	98/522 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   284 ISAANQPPFIFRIRTLDSSGMGQLRWDGVEFRLLTMISKRLNFSIDITETPT----RSNTRGVVD 344
            ::...:.||:. .|..|.:..|..|::|....||..::..|.||.:|.....    ..:.:|..:
Mouse   438 VTTVLEEPFVM-FRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWN 501

  Fly   345 TIQEQIIERTVDIGMSGIYIT--QERLMDSAMSVGHSPDCAAFITLASKAL--------PKYRAI 399
            .:.:::|:...|:.::.:.||  :|:.:|.:         ..|:||....|        |...:.
Mouse   502 GMVKELIDHKADLAVAPLTITHVREKAIDFS---------KPFMTLGVSILYRKPNGTNPSVFSF 557

  Fly   400 MGPFQWPVWVALICVYLGGIFPIVFTDRLTL------------SHLMGNWGEVENMFWYVFGMFT 452
            :.|....:|:.::..|||....:....|.:.            |.::.|...:.|.||:..|
Mouse   558 LNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMG--- 619

  Fly   453 NAFSFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTGSIIAFVTLPAFPDTVDSVLDLL-GLF 516
               |...:.|....:..|||::.|.:|.||:||.|.||.::.||:|:......:||..||. ...
Mouse   620 ---SLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTK 681

  Fly   517 FRVGTLNNGGWETWFQNSTHIPTSRLY-----KKMEFVGSVDEGIGNVTQSFFWNYAFLGSKAQL 576
            ...|.:.:|...|:|:.|......:::     |....|.:.:|||.....:   :||.|.....:
Mouse   682 IEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRTLTA---DYALLMESTTI 743

  Fly   577 EYLVQSNFSDENISRRSALHLSEECFALFQIGFLF---------PRESVYKIKIDSMILLAQQSG 632
            ||:.|.|.:                  |.|||.|.         |..|.|:.||...||..|:..
Mouse   744 EYITQRNCN------------------LTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEED 790

  Fly   633 LIAKINNEVSWVMQRSSSGRLLQASSSNSLREIIQEERQLTTADTEGMFLLMALGYFLGATALVS 697
            .: .|..|..|             ..|....|..:|...|......|:|:::|.|..|.....|.
Mouse   791 KL-HIMKEKWW-------------RGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVG 841

  Fly   698 EIVGGITNKCRQIIKRSRKSAASSWSSASSGSMLRTNAEQLSHDKRKANRREAAEVAQKMSFGMR 762
            |.:    .|.|:..:|.::|..|:.:.....|:  |...:|.|..:.....:...|....:|..|
Mouse   842 EFI----YKLRKTAEREQRSFCSTVADEIRFSL--TCQRRLKHKPQPPMMVKTDAVINMHTFNDR 900

  Fly   763 EL 764
            .|
Mouse   901 RL 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	74/325 (23%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	66/281 (23%)
Grik3	NP_001074566.1	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	91/413 (22%)
		Glutamate binding. /evidence=ECO:0000250	690..692		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810