DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir21a and Grik2

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	XP_011241422.1	Gene:	Grik2 / 14806	MGIID:	95815	Length:	943	Species:	Mus musculus

Alignment Length:	779	Identity:	161/779 - (20%)
Similarity:	269/779 - (34%)	Gaps:	216/779 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 VNSYNFEQTNS----LVGLVNKIAQEYLNKCPPVIYYDSFVEKSDGLILENLFKTIPITFYHG-- 144
            ||...|...|:    :..::.|.:.|.| :.||         |.|..:|:....|.....|..
Mouse   274 VNMTGFRILNTENTQVSSIIEKWSMERL-QAPP---------KPDSGLLDGFMTTDAALMYDAVH 328

  Fly   145 EINADYEAKNKRFTSHIDCNCKSYILFLSDPLMTRKILGPQTESRVVLVSRSTQWRLRDFLSSEL 209
            .::...:...:...|.:.||......|               .:|.:.:.:...|   :.|:..:
Mouse   329 VVSVAVQQFPQMTVSSLQCNRHKPWRF---------------GTRFMSLIKEAHW---EGLTGRI 375

  Fly   210 SSNIVNLLVIGESLMADPMRERPYVLYTHKLYADGL---GSNTP---VVLTSWIKGALSRPHINL 268
            :.|..|      .|..|      :.|....|..:||   |:..|   :.:|...||.
Mouse   376 TFNKTN------GLRTD------FDLDVISLKEEGLEKIGTWDPSSGLNMTESQKGK-------- 420

  Fly   269 FPSKFQFGFAGHRFQISAANQPPFIFRIRTLDSSGMGQLRWDGVEFRLLTMISKRLNFSIDIT-- 331
             |:......:.....::...:.|::. .:..|....|..|::|....||..:|..|.|:.:|.
Mouse   421 -PANITDSLSNRSLIVTTILEEPYVL-FKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLV 483

  Fly   332 ---ETPTRSNTRGVVDTIQEQIIERTVDIGMSGIYIT--QERLMDSAMSVGHSPDCAAFITLASK 391
               :...:.:..|..:.:..::|:...|:.::.:.||  :|:::|.:         ..|:||...
Mouse   484 EDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFS---------KPFMTLGIS 539

  Fly   392 AL--------PKYRAIMGPFQWPVWVALICVYLG---GIFPIVFTDR------------------ 427
            .|        |...:.:.|....:|:.::..|||   .:|.|....:
Mouse   540 ILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARQSKFSWFKYPNCSHYHHSQRC 604

  Fly   428 LTLSHLMG----------NW----------GEVE------NMFWYVFGMFTNAFSFTGKYSWSNT 466
            |...||..          .|          ..||      |.||:..|      :...:.|....
Mouse   605 LCTQHLESYMELCLFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVG------ALMQQGSELMP 663

  Fly   467 RKNSTRLLIGAYWLFTIIITSCYTGSIIAFVTLPAFPDTVDSVLDLL-GLFFRVGTLNNGGWETW 530
            :..|||::.|.:|.||:||.|.||.::.||:|:......:||..||. ......|.:.:|...|:
Mouse   664 KALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTF 728

  Fly   531 FQNSTHIPTSRLYKKM----------EFVGSVDEGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFS 585
            |:.| .|.|   |.||          ..|.|.:|||..|..|   :||||.....:|::.|.|.:
Mouse   729 FKKS-KIST---YDKMWAFMSSRRQSVLVKSNEEGIQRVLTS---DYAFLMESTTIEFVTQRNCN 786

  Fly   586 DENISRRSALHLSEECFALFQIGFLF---------PRESVYKIKIDSMILLAQQSGLIAKINNEV 641
                              |.|||.|.         |..|.|:.||...||..|:.|.: .:..|.
Mouse   787 ------------------LTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKL-HMMKEK 832

  Fly   642 SWVMQRSSSGRLLQASSSNSLREIIQEERQLTTADTEGMFLLMALGYFLGATALVSEIVGGITNK 706
            .|             ..:....|..:|...|...:..|:|:::|.|..|.....|.|.:.. :.|
Mouse   833 WW-------------RGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYK-SKK 883

  Fly   707 CRQIIKRSRKSAASSWSSASSGSMLRTNAEQLSHDKRKANRREA------AEVAQKMSFGMREL 764
            ..|:.|||..||           |:......|...:|..::.:|      .||....:|..|.|
Mouse   884 NAQLEKRSFCSA-----------MVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRRL 936

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	83/366 (23%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	76/321 (24%)
Grik2	XP_011241422.1	PBP1_iGluR_Kainate	37..414	CDD:380605	31/179 (17%)
Grik2	XP_011241422.1	Periplasmic_Binding_Protein_Type_2	430..835	CDD:389745	100/459 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910