Protein Alignment Ir21a and Grik1

DIOPT Version :10

• Sequence 1: NP_001097043.1
• Gene: Ir21a / 33157
• FlyBaseID: FBgn0031209
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: NP_001391957.1
• Gene: Grik1 / 14805
• MGIID: 95814
• Length: 949
• Species: Mus musculus
• Alignment Length: 644
• Identity: 141/644 - (21%)
• Similarity: 243/644 - (37%)
• Gaps: 145/644 - (22%)

  Fly   182 LGPQTESRVVLVSRSTQW---------RLRDFLSSELSSNIVNLLVIGESLMADPMRERPYVLYT 237
            |||    |.:.:.:..:|         ...|.|..:...:|::|...|....:..:.:..|.::
Mouse   356 LGP----RFMNLIKEARWDGLTGRITFNKTDGLRKDFDLDIISLKEEGTEKASGEVSKHLYKVW- 415

  Fly   238 HKLYADGL-GSNTPVVLTSWIKGALSRPHINLFPSKFQFGFAGHRFQISAANQPPFIFRIRTLDS 301
            .|:   |: .||:.:.:|.   |...|.: |:..|     .|.....::...:.|::. .|..|.
Mouse   416 KKI---GIWNSNSGLNMTD---GNRDRSN-NITDS-----LANRTLIVTTILEEPYVM-YRKSDK 467

  Fly   302 SGMGQLRWDGVEFRLLTMISKRLNFSIDITETPT----RSNTRGVVDTIQEQIIERTVDIGMSGI 362
            ...|..|::|....||..:|..|.|..|:...|.    ..|.:|..:.:.:::|:...|:.::.:
Mouse   468 PLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPL 532

  Fly   363 YIT--QERLMDSAMSVGHSPDCAAFITLASKAL--------PKYRAIMGPFQWPVWVALICVYLG 417
            .||  :|:::|.:         ..|:||....|        |...:.:.|....:|:.::...||
Mouse   533 TITYVREKVIDFS---------KPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLG 588

  Fly   418 GIFPIVFTDRLTL------------SHLMGNWGEVENMFWYVFGMFTNAFSFTGKYSWSNTRKNS 470
            ....:....|.|.            |.::.|...:.|.||:..|      :...:.|....:..|
Mouse   589 VSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVG------ALMQQGSELMPKALS 647

  Fly   471 TRLLIGAYWLFTIIITSCYTGSIIAFVTLPAFPDTVDSVLDLL-GLFFRVGTLNNGGWETWFQNS 534
            ||::.|.:|.||:||.|.||.::.||:|:......:||..||. ......|.:.:|...|:|:.|
Mouse   648 TRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKS 712

  Fly   535 THIPTSRLYKKM----------EFVGSVDEGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFSDENI 589
             .|.|   |:||          ..|.:.||||..|..:   :||.|.....:||:.|.|.:
Mouse   713 -KIST---YEKMWAFMSSRQQSALVKNSDEGIQRVLTT---DYALLMESTSIEYVTQRNCN---- 766

  Fly   590 SRRSALHLSEECFALFQIGFLF---------PRESVYKIKIDSMILLAQQSGLIAKINNEVSWVM 645
                          |.|||.|.         |..|.|:.||...||..|:.|.: .:..|..|
Mouse   767 --------------LTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKL-HMMKEKWW-- 814

  Fly   646 QRSSSGRLLQASSSNSLREIIQEERQLTTADTEGMFLLMALGYFLGATALVSEIVGGITNKCRQI 710
                       ..:....|..:|...|...:..|:|:::|.|..|.....:.|           .
Mouse   815 -----------RGNGCPEEDSKEASALGVENIGGIFIVLAAGLVLSVFVAIGE-----------F 857

  Fly   711 IKRSRKSAASSWSSASSGSMLRTNAEQLSHDKRKANRREAAEVAQKMSFG--MRELNLT 767
            |.:|||:........||........:...|    .::.|:..|.:.:||.  |.||.::
Mouse   858 IYKSRKNNDIEQKGKSSRLRFYFRNKVRFH----GSKTESLGVEKCLSFNAIMEELGIS 912

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	HisJ	287..>392	CDD:440596	24/110 (22%)
		Lig_chan	405..662	CDD:459656	70/288 (24%)
Grik1	NP_001391957.1	PBP1_iGluR_Kainate	38..431	CDD:380605	15/82 (18%)
		Periplasmic_Binding_Protein_Type_2	446..815	CDD:473866	97/423 (23%)