Protein Alignment Ir21a and Grid2

DIOPT Version :10

• Sequence 1: NP_001097043.1
• Gene: Ir21a / 33157
• FlyBaseID: FBgn0031209
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: NP_032193.1
• Gene: Grid2 / 14804
• MGIID: 95813
• Length: 1007
• Species: Mus musculus
• Alignment Length: 628
• Identity: 124/628 - (19%)
• Similarity: 220/628 - (35%)
• Gaps: 179/628 - (28%)

  Fly   245 LGSNTPVVLTSWIKGALSRPHINLFPSKFQFGFAGHRFQISAANQPPFIFRIRTLDSSGMGQ-LR 308
            ||...||   :.:.|:|:       ..|.:....|...::....:.||:.    :..:.:|: .:
Mouse   416 LGCWNPV---TGLNGSLT-------DKKLENNMRGVVLRVVTVLEEPFVM----VSENVLGKPKK 466

  Fly   309 WDGVEFRLLTMISKRLNFSIDITETPTRS----NTRGVVDTIQEQIIERTVDIGMSGIYITQE-- 367
            :.|....:|..:|..|.|:.:|...|...    ...|..:.:..:::.:..|||:|.:.||.:
Mouse   467 YQGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDRE 531

  Fly   368 -------RLMDSAMSVGHSPDCAAFITLASKALPKYRAIMGPFQWPVW---------VALICVYL 416
                   |.||.::.|        .:..|.|.:..: |.:.||...:|         |.|:...|
Mouse   532 NVVDFTTRYMDYSVGV--------LLRRAEKTVDMF-ACLAPFDLSLWACIAGTVLLVGLLVYLL 587

  Fly   417 GGIFPIVFTDRLTLSHLMGNWGEVENMFWYVFGMFTNAFSFTGKYSWSNTRKNSTRLLIGAYWLF 481
            ..:.|    .||.:..:...  .:.|..|:|:|.|...   .|:..::..   :||:::||:|||
Mouse   588 NWLNP----PRLQMGSMTST--TLYNSMWFVYGSFVQQ---GGEVPYTTL---ATRMMMGAWWLF 640

  Fly   482 TIIITSCYTGSIIAFVTLPAFPDTVDSVLDLLGLFFRVGTLNNGGWETWFQNSTHIP-----TSR 541
            .:|:.|.||.::.||:|:.....::.|:.||                   ...|.||     .|.
Mouse   641 ALIVISSYTANLAAFLTITRIESSIQSLQDL-------------------SKQTDIPYGTVLDSA 686

  Fly   542 LYKKMEFVG-------------------------SVDEGIGNVTQSFFWNYAFLGSKAQLEYLVQ 581
            :|:.:...|                         :|.|....:.:..:.||||:...|.|||:.
Mouse   687 VYQHVRMKGLNPFERDSMYSQMWRMINRSNGSENNVLESQAGIQKVKYGNYAFVWDAAVLEYVA- 750

  Fly   582 SNFSDENISRRSALHLSEECFALFQIGFLFPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQ 646
              .:|.:.|    .:......|....|......|.|:......||..||||.:..:.::  |..:
Mouse   751 --INDPDCS----FYTVGNTVADRGYGIALQHGSPYRDVFSQRILELQQSGDMDILKHK--WWPK 807

  Fly   647 RSSSGRLLQASSSNSLREIIQEERQLTTADTEGMFLLMALGYFLGATALVSEIVGGITNKCRQII 711
            ..      |....:|: :..|:...|......|:|.::|.|..|.....|.|
Mouse   808 NG------QCDLYSSV-DAKQKGGALDIKSLAGVFCILAAGIVLSCLIAVLE------------- 852

  Fly   712 KRSRKSAASSWSSASSGSMLRTNAEQLSHDKRKANRREAAEVAQKMSFGMRELNLTRATLREIYG 776
                     :|.|...||.:.:..:....|....:||
Mouse   853 ---------TWWSRRKGSRVPSKEDDKEIDLEHLHRR---------------------------- 880

  Fly   777 SYGAPETDHGQLDIVHTEFPNSSAKLN--NIEDEESREALESL 817
             ..:..||.   |..|.:|..||..|.  :|:...:|:|||.:
Mouse   881 -VNSLCTDD---DSPHKQFSTSSIDLTPLDIDTLPTRQALEQI 919

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	HisJ	287..>392	CDD:440596	22/118 (19%)
		Lig_chan	405..662	CDD:459656	60/295 (20%)
Grid2	NP_032193.1	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250|UniProtKB:O43424	24..345
		Periplasmic_Binding_Protein_type1	28..429	CDD:471960	5/15 (33%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	86/418 (21%)
		Interaction with AP4M1. /evidence=ECO:0000250|UniProtKB:Q63226	921..991
		PDZ-binding	1005..1007