DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir21a and Grid1

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_032192.2	Gene:	Grid1 / 14803	MGIID:	95812	Length:	1009	Species:	Mus musculus

Alignment Length:	851	Identity:	163/851 - (19%)
Similarity:	305/851 - (35%)	Gaps:	259/851 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 RRIVPTFQGNPRPRGELLASKFHVNSYNFEQTNSLVGLVNKIAQEYLNKCPPVIYYDSFVEKSDG 127
            |:|.|:.:.|.:    .:.:...::|...:.....:.:: :|:..||        |||.
Mouse   282 RQIFPSAKDNQK----CMRNNHRISSLLCDPQEGYLQML-QISNLYL--------YDSV------ 327

  Fly   128 LILENLFKTIPITFYHGEINADYEAKNKRFTSHIDCNCKSYILFLSDPLMTRKILGPQTESRVVL 192
            |:|.|.|        |.::      :::::.|....||
Mouse   328 LMLANAF--------HRKL------EDRKWHSMASLNC--------------------------- 351

  Fly   193 VSRSTQ-WR-LRDFLSSELSSNIVNLLVIGESLMADPMRE---RPYVLY--THKLYADGLGSNTP 250
            :.:||: |. .|..|.:....:|..|..:.|      .||   .|||.:  ....|::..|.:..
Mouse   352 IRKSTKPWNGGRSMLDTIKKGHITGLTGVME------FREDSSNPYVQFEILGTTYSETFGKDMR 410

  Fly   251 VVLTSW-----IKGAL-SRPHINLFPSKFQFGFAGHRFQISAANQPPFIFRIRTLDSSGMGQ-LR 308
             .|.:|     :.|:| .||    ..|:.|    |...::....:.||:.....:    :|| .|
Mouse   411 -KLATWDSEKGLNGSLQERP----MGSRLQ----GLTLKVVTVLEEPFVMVAENI----LGQPKR 462

  Fly   309 WDGVEFRLLTMISKRLNFSIDITETPT--------RSNTRGVVDTIQEQIIERTVDIGMSGIYIT 365
            :.|....:|..::|.|.|..:|.:.|.        .::..|::.    ::|.:..|:.:|.|.||
Mouse   463 YKGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNTSWNGMIG----ELISKRADLAISAITIT 523

  Fly   366 QE---------RLMDSAMSVGHSPDCAAFITLASKALPKYR--AIMGPFQWPVWVALICVYLGGI 419
            .|         |.||.::.:           |..|...|..  ::..||.:.||.   |:  ...
Mouse   524 PERESVVDFSKRYMDYSVGI-----------LIKKPEEKISIFSLFAPFDFAVWA---CI--AAA 572

  Fly   420 FPIVFTDRLTLSHLMGNWGE------------VENMFWYVFGMFTNAFSFTGKYSWSNTRKNSTR 472
            .|:|......|:.:.....:            :.:..|.|:|      :|..:...|:....:.|
Mouse   573 IPVVGVLIFVLNRIQAVRSQSATQPRPSASATLHSAIWIVYG------AFVQQGGESSVNSVAMR 631

  Fly   473 LLIGAYWLFTIIITSCYTGSIIAFVTLPAFPDTVDSVLDL-LGLFFRVGTLNNGGWETWF----- 531
            :::|::||||:|:.|.||.::.||:|:....:.:.:..|| ..|....||:.:.....:|
Mouse   632 IVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQLEMSYGTVRDSAVYEYFRAKGT 696

  Fly   532 ----QNSTHIPTSRLYKKMEFVGSVDEGIGN----VTQSFFWNYAFLGSKAQLEYLVQSNFSDEN 588
                |:||.   :.|::.:...|..|..:.|    :.::...|||||...|.:||   :..:|::
Mouse   697 NPLEQDSTF---AELWRTISKNGGADNCVSNPSEGIRKAKKGNYAFLWDVAVVEY---AALTDDD 755

  Fly   589 ISRRSALHLSEECFALFQIGFLFPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGR- 652
            .|    :.:.....:....|......|.|:......||..|.:|.:..:..:  |   ...:||
Mouse   756 CS----VTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQK--W---WPHTGRC 811

  Fly   653 -LLQASSSNSLREIIQEERQLTTADTEGMFLLMALGYFLGATALVSEIVGGITNKCRQIIKRSRK 716
             |...||:.:      |.:.|......|:|.::|:|..|.......|:... :|:|.|...:..|
Mouse   812 DLTSHSSTQT------EGKSLKLHSFAGVFCILAIGLLLACLVAALELWWN-SNRCHQETPKEDK 869

  Fly   717 SAASSWSSASSGSMLRTNAEQLSHDKRKANRREAAEVAQKMSFGMRELNLTRATLREIYGSYGAP 781
                           ..|.||               |.::::..|.|
Mouse   870 ---------------EVNLEQ---------------VHRRINSLMDE------------------ 886

  Fly   782 ETDHGQLDIVHTEFPNSSAKLNNIED---------EESREALESLQRLDEFMDQMDNDG------ 831
                   ||.|.:...:|.:|:.:|.         |.:||...:...:..|:.:..:.|
Mouse   887 -------DIAHKQISPASIELSALEMGGLAPSQALEPTREYQNTQLSVSTFLPEQSSHGTSRTLS 944

  Fly   832 -NPSSH 836
             .|||:
Mouse   945 SGPSSN 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	73/339 (22%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	60/282 (21%)
Grid1	NP_032192.2	Interaction with CBLN1. /evidence=ECO:0000269\|PubMed:27418511	21..436		42/228 (18%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	36/207 (17%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	84/414 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..960		4/20 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810