DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir21a and Gria4

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	XP_006509904.1	Gene:	Gria4 / 14802	MGIID:	95811	Length:	912	Species:	Mus musculus

Alignment Length:	753	Identity:	139/753 - (18%)
Similarity:	265/753 - (35%)	Gaps:	227/753 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 FHVNSYNFEQTNSLVGLVNKIAQ-EYL-NKCPP----VIYYDSFV-----------EKSD----- 126
            |.:..:|......|:....|:.| ||. ::.||    .:.||..:           :|.|
Mouse   262 FQLVDFNTPMVTKLMDRWKKLDQREYPGSETPPKYTSALTYDGVLVMAETFRSLRRQKIDISRRG 326

  Fly   127 ---------------GLILENLFKTIPITFYHGEINADYEAKNKRFTSHIDCNCKSYILFLSDPL 176
                           |:.:|...|.:.|....|.:..|:..:...:|..:      :.|..:.|
Mouse   327 NAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMDV------FELKSTGP- 384

  Fly   177 MTRKILGPQTESRVVLVSRSTQWRLRDFLSSELSSNIVNLLVIGESLMADPMRERPYVLY--THK 239
              ||:.......::||:..:..      |.::.:: |.|..|:..::|     |.|||:|  .|:
Mouse   385 --RKVGYWNDMDKLVLIQDAPT------LGNDTAA-IENRTVVVTTIM-----ESPYVMYKKNHE 435

  Fly   240 LYADGLGSNTPVVLTSWIKGALSRPHINLFPSKFQFGFAGHRFQISAANQPPFIFRIRTLDSSGM 304
            ::.
Mouse   436 MFE-------------------------------------------------------------- 438

  Fly   305 GQLRWDGVEFRLLTMISKRLNFSIDITETP-----TRSNTRGVVDTIQEQIIERTVDIGMSGIYI 364
            |..:::|....|.:.|:|.:.....|...|     .|.....:.:.:..:::....:|.::.:.|
Mouse   439 GNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTI 503

  Fly   365 T--QERLMDSA---MSVGHSPDCAAFITLASKALPKYRAIMGPFQWPVWVALICVYLGGIFPIVF 424
            |  :|.::|.:   ||:|.|    ..|....|:.|...:.:.|..:.:|:.::..|: |:..::|
Mouse   504 TLVREEVIDFSKPFMSLGIS----IMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYI-GVSVVLF 563

  Fly   425 TDRLTLSHLMGNWGEVENMFWYV-----------------FGMFTNAFSFTGKYSWS----NTRK 468
                    |:..:...|   |:.                 ||:|.:.:...|.:...    :.|.
Mouse   564 --------LVSRFSPYE---WHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRS 617

  Fly   469 NSTRLLIGAYWLFTIIITSCYTGSIIAFVTLPAFPDTVDSVLDLL-GLFFRVGTLNNGGWETWFQ 532
            .|.|::.|.:|.||:||.|.||.::.||:|:......::|..||. ......|||::|..:.:|:
Mouse   618 LSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFR 682

  Fly   533 NSTHIPTSRLYKKM----------EFVGSVDEGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFSDE 587
            .|    ...:|:||          .|..:..||:..|.:| ...:|||......||:.|....|.
Mouse   683 RS----KIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKS-KGKFAFLLESTMNEYIEQRKPCDT 742

  Fly   588 -----NISRRSALHLSEECFALFQIGFLFPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQR 647
                 |:..:.             .|...|:.|..:..::..:|...::|::.|:.|:  |...:
Mouse   743 MKVGGNLDSKG-------------YGVATPKGSSLRTPVNLAVLKLSEAGVLDKLKNK--WWYDK 792

  Fly   648 SSSGRLLQASSSNSLREIIQEERQLTTADTEGMFLLMALGYFLGATALVSEIVGGITNKCRQIIK 712
            ...|.....|...:        ..|:.::..|:|.::..|  ||...||:.|         :...
Mouse   793 GECGPKDSGSKDKT--------SALSLSNVAGVFYILVGG--LGLAMLVALI---------EFCY 838

  Fly   713 RSRKSAASSWSSASSGSMLRTNAEQLSHDKRKANRREA 750
            :|| :.|.....|.|.......:.|.:|:  .|..|||
Mouse   839 KSR-AEAKRMKVAKSAQTFNPTSSQNTHN--LATYREA 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	70/335 (21%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	61/291 (21%)
Gria4	XP_006509904.1	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	26/146 (18%)
Gria4	XP_006509904.1	PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	89/483 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910