Protein Alignment Ir21a and Ir21a

DIOPT Version :10

• Sequence 1: NP_001097043.1
• Gene: Ir21a / 33157
• FlyBaseID: FBgn0031209
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: XP_061512550.1
• Gene: Ir21a / 1277460
• VectorBaseID: AGAMI1_006843
• Length: 975
• Species: Anopheles gambiae
• Alignment Length: 897
• Identity: 385/897 - (42%)
• Similarity: 534/897 - (59%)
• Gaps: 75/897 - (8%)

  Fly    11 FTAQAFSIEG-DRSASYQEKCISRRLINHYQLNKEIFGVGMC-------DGNNENEFRQKRRIVP 67
            |..|....:| |.|..|.|..........|.|.:|:.....|       ..|.....|.:||:.|
Mosquito    31 FNQQLIRYKGRDSSNGYFELASEAYYTGAYDLVEELNETATCWRADCREQSNGSPVVRDRRRVDP 95

  Fly    68 TFQGNPRPRGELLASKF-HVNSYNFEQTNSLVGLVNKIAQEYLNKCPPVIYYDSFVEKSDGLILE 131
            ||.|:|:.|.::....| ||...| .||.|||.|:|||..:||:.|.|::.:|::|..::..:||
Mosquito    96 TFYGHPKTREQIWERNFAHVIEDN-RQTLSLVTLLNKIILKYLHSCIPIVLFDTYVATTENYMLE 159

  Fly   132 NLFKTIPITFYHGEINADYEAKNKRFTSHIDCNCKSYILFLSDPLMTRKILGPQTESRVVLVSRS 196
            .||...|||:..|.|..:|...|..........|:|||:||:|.:||||::|||..|.|||:.||
Mosquito   160 ALFSDFPITYITGRIGPNYTLDNPGILEPTGPQCRSYIIFLADVMMTRKVIGPQMNSYVVLIPRS 224

  Fly   197 TQWRLRDFLSSELSSNIVNLLVIGESLMADPM--RERPYVLYTHKLYADGLGSNTPVVLTSWIKG 259
            :||:|::||:::.|.:|:||||||||...|..  .|:|||||||:||.||||:|.|.||||||..
Mosquito   225 SQWKLQEFLAAKQSRDIINLLVIGESYSVDKRINNEQPYVLYTHELYIDGLGANRPQVLTSWIGN 289

  Fly   260 ALSRPHINLFPSKFQFGFAGHRFQISAANQPPFIFRIRTLDSSGMGQLRWDGVEFRLLTMISKRL 324
            ..||.::||||.|.:.||:||||.:.||:||||:.:..:.|..|...:||:|:|.|||.::::.|
Mosquito   290 KFSRNNVNLFPRKLRKGFSGHRFTVKAAHQPPFMIKRLSTDGVGNVNIRWEGLEMRLLRVMAQYL 354

  Fly   325 NFSIDITETPTRSNTRGVVDTIQEQIIERTVDIGMSGIYITQERLMDSAMSVGHSPDCAAFITLA 389
            ||:.||.| |.|:.. |..|.:.|:|.....|:|::|||:|.||.:.:.|||.||.|||||:||.
Mosquito   355 NFTYDIIE-PGRTEL-GPGDAVVEEIKRGQGDMGLAGIYVTIERNLATEMSVSHSTDCAAFLTLM 417

  Fly   390 SKALPKYRAIMGPFQWPVWVALICVYLGGIFPIVFTDRLTLSHLMGNWGEVENMFWYVFGMFTNA 454
            |.|||:||||:||||||||||:|.:||..|||:.|:|::||.||:|||.|:|||||||||.|||:
Mosquito   418 SSALPRYRAILGPFQWPVWVAVILIYLLAIFPLAFSDKMTLRHLLGNWSEIENMFWYVFGTFTNS 482

  Fly   455 FSFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTGSIIAFVTLPAFPDTVDSVLDLLGLFFRV 519
            .:|.|:.|||||||.|||:|||.||:||||||:|||||||||:|||..|:.:|.:..|...||||
Mosquito   483 LTFQGENSWSNTRKTSTRMLIGIYWVFTIIITACYTGSIIAFITLPVEPERIDGIEQLSRGFFRV 547

  Fly   520 GTLNNGGWETWFQNSTHIPTSRLYKKMEFVGSVDEGIGNVTQSFFWNYAFLGSKAQLEYLVQSNF 584
            |||:.||||.||.||:|..|::|.|.:.||.||||||.|||::|..:|||:|||.:||:|::||.
Mosquito   548 GTLDRGGWERWFLNSSHKQTNKLLKDLRFVSSVDEGIRNVTEAFLISYAFIGSKGELEFLIKSNL 612

  Fly   585 SDENISRRSALHLSEECFALFQIGFLFPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSS 649
            |.:..::|..||:|.|||||:.:..:||..||::..|::.||..|::|||.|:|.:|:|...::.
Mosquito   613 SHQFENKRYGLHVSRECFALYGVSMVFPPNSVHRDPINNAILYMQEAGLIGKLNRDVTWETMKTK 677

  Fly   650 SGRLLQASSSNSLREIIQEERQLTTADTEGMFLLMALGYFLGATALVSEIVGGITNKCRQIIK-- 712
            .||..:||....||.....||.||.||||||||||..||.:....|:||.|||.|||||:::|
Mosquito   678 DGRRKEASVGEVLRSTAPSERGLTLADTEGMFLLMLFGYVVALGVLISEWVGGCTNKCREVLKER 742

  Fly   713 --RSRKSAASSWSSASSGS-------MLRTNAEQLSHDKRKANR--REAAEVAQKMSFGMRELNL 766
              |.:.:||...::|::||       ...|:..:.|..||....  ..:...:...|..:|.:.|
Mosquito   743 AERLKAAAAEIAAAATAGSDNGSLPVSSPTSTNRNSPHKRTGPNGVENSLPASGNGSATVRRIRL 807

  Fly   767 T--------------------------RATLREIYGS---------YGAPETDHGQLDIVHTEFP 796
            |                          |.:|.|....         |..|:..|..:..:..:..
Mosquito   808 TGEDSENEPNEYDVPPDAASDGGSSLQRHSLSECLSEVSAHTMQDLYNGPDRRHSTIVFLDGQLM 872

  Fly   797 NSSAKLNNIEDEESR------EALE-SLQRLDEFMDQMDNDGNPSSHTFRID 841
            :.......:...:||      ..|| .:.:|..|:      |..|.|:.|.|
Mosquito   873 SEEEAQRKVARSKSRHRHSLSSVLEREVSQLFRFL------GKESPHSARAD 918

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	HisJ	287..>392	CDD:440596	47/104 (45%)
		Lig_chan	405..662	CDD:459656	143/256 (56%)
Ir21a	XP_061512550.1	None