Protein Alignment Ir21a and GRIN3B

DIOPT Version :9

• Sequence 1: NP_001097043.1
• Gene: Ir21a / 33157
• FlyBaseID: FBgn0031209
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: NP_619635.1
• Gene: GRIN3B / 116444
• HGNCID: 16768
• Length: 1043
• Species: Homo sapiens
• Alignment Length: 498
• Identity: 102/498 - (20%)
• Similarity: 176/498 - (35%)
• Gaps: 105/498 - (21%)

  Fly   287 ANQPPFIFRIRTLDSSGMGQL---RWDGVEFRLLTMISKRLNFSIDITETPTRSNTRGVVDTIQE 348
            |...||.|.:..:.....|.|   ||.|:...||   :.|.:.::          |...:::.:.
Human   488 AEDTPFDFELYLVGDGKYGALRDGRWTGLVGDLL---AGRAHMAV----------TSFSINSARS 539

  Fly   349 QIIERTVDIGMSGIYITQERLMDSAMSVGHSPDCAAFITLASKALPKYRAIMGPFQWPVWVALI- 412
            |:::.|.....:.:.| ..|..|:|..:|                    |.|.|..|..|:.:.
Human   540 QVVDFTSPFFSTSLGI-MVRARDTASPIG--------------------AFMWPLHWSTWLGVFA 583

  Fly   413 CVYLGGIF--------PIVFTDRLTLSHLMGNWGEVENMFWYVFGMFTNAFSFTGKYSWSNTRKN 469
            .::|..:|        |...|.|......:.::....|:.:.:  :|....|       |.|.|.
Human   584 ALHLTALFLTVYEWRSPYGLTPRGRNRSTVFSYSSALNLCYAI--LFRRTVS-------SKTPKC 639

  Fly   470 ST-RLLIGAYWLFTIIITSCYTGSIIAFV----TLPAFPDTVDSVLDLLGLFFRVGTLNNGGWET 529
            .| |||:..:.:|.:::.|.||.::.|.:    |........|..|......||.||:.....|.
Human   640 PTGRLLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWESSAEA 704

  Fly   530 WFQNSTHIPTSRLYKKMEFVGSVDEGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFSDENISRRSA 594
            :.:.|  .|....:.:.....:...|:..:|.......||:..|:.|:|.|.
Human   705 YIKKS--FPDMHAHMRRHSAPTTPRGVAMLTSDPPKLNAFIMDKSLLDYEVS------------- 754

  Fly   595 LHLSEEC--------FALFQIGFLFPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSG 651
              :..:|        ||:...|...|:.|.....:...|...:.||.|..::::  |........
Human   755 --IDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDK--WYKMVPCGK 815

  Fly   652 RLLQASSSNSLREIIQEERQLTTADTEGMFLLMALGYFLGATALVSEIVGGITNKCRQIIKRSRK 716
            |:.          .:.|..|::.....|:|:|:.||  || :||:|.:  |.....|..:.|.||
Human   816 RVF----------AVTETLQMSIYHFAGLFVLLCLG--LG-SALLSSL--GEHAFFRLALPRIRK 865

  Fly   717 -SAASSWSSASSGSMLRTNAEQLSHDKRKANRREAA--EVAQK 756
             |....|...|.......|.|.....|.:....|.:  ||.|:
Human   866 GSRLQYWLHTSQKIHRALNTEPPEGSKEETAEAEPSGPEVEQQ 908

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	62/310 (20%)
		Lig_chan	407..662	CDD:278489	51/276 (18%)
GRIN3B	NP_619635.1	PBP1_iGluR_NMDA_NR3	19..405	CDD:107372
		PBP2_iGluR_NMDA_Nr3	415..808	CDD:270438	73/381 (19%)
		Lig_chan	576..842	CDD:278489	58/305 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810