DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir21a and GRIN3A

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_597702.2	Gene:	GRIN3A / 116443	HGNCID:	16767	Length:	1115	Species:	Homo sapiens

Alignment Length:	912	Identity:	163/912 - (17%)
Similarity:	296/912 - (32%)	Gaps:	288/912 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 SKFHVNSY-----NFEQTNSLVGLVNKIAQEYLNKCPPVIYYDSFVEKSDGLILENLFKTIPITF 141
            ||||:.|.     |...|..|:..:....:...|..|.|:.:        |..:|::.:...||.
Human   287 SKFHLGSIINITANLPSTQDLLSFLQIQLESIKNSTPTVVMF--------GCDMESIRRIFEITT 343

  Fly   142 YHGEINADYE----------------------AKNKRFTSHIDCNCKSYILFLSDPLMTRKILGP 184
            ..|.:..:..                      |..|...|..:...:..:..::..:.|..::.|
Human   344 QFGVMPPELRWVLGDSQNVEELRTEGLPLGLIAHGKTTQSVFEHYVQDAMELVARAVATATMIQP 408

  Fly   185 QTESRVVLVS--------RSTQWRLRDFLSSELSSNIV-----NLLVIGESLMADPMRERPYVLY 236
            :    :.|:.        .:|......:||..|::...     ::.|.|.::::.   |..:.::
Human   409 E----LALIPSTMNCMEVETTNLTSGQYLSRFLANTTFRGLSGSIRVKGSTIVSS---ENNFFIW 466

  Fly   237 THKLYADGLGSNTPVVLTSWIKGAL----------SRPHINLF--PSKFQFGFAGHRFQISAANQ 289
              .|..|.:|......|.||..|.:          ::.|...|  |||.       ..::....:
Human   467 --NLQHDPMGKPMWTRLGSWQGGKIVMDYGIWPEQAQRHKTHFQHPSKL-------HLRVVTLIE 522

  Fly   290 PPFIFRIRTLDSSGM---GQLRWD-----------------------GVEFR---------LLTM 319
            .||:| .|.:|..|:   |||..|                       .::|:         ||..
Human   523 HPFVF-TREVDDEGLCPAGQLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDLLEK 586

  Fly   320 ISKRLNFSID------------------------ITETPTRSNTRGVVDTIQEQIIERTVDIGMS 360
            |::.:||..|                        :..|...:.|...::|.:.|:|:.|.....:
Human   587 IAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLRGTAHMAVTSFSINTARSQVIDFTSPFFST 651

  Fly   361 --GIYITQERLMDSAMSVGHSPDCAAFITLASKALPKYRAIMGPFQWPVWVAL-ICVYLGGIFPI 422
              ||.:   |..|:|..:|                    |.|.|..|.:|:.: :.:::..:|
Human   652 SLGILV---RTRDTAAPIG--------------------AFMWPLHWTMWLGIFVALHITAVF-- 691

  Fly   423 VFTDRLTLSHLMGNWGEVENMFWYVFGMFTNAFSFTGKYSWSNTRKNSTRLLIGAYWLFTIII-- 485
                 |||.    .|..       .||:.....:.:..:|:|:.......||.|.    |:.|
Human   692 -----LTLY----EWKS-------PFGLTPKGRNRSKVFSFSSALNICYALLFGR----TVAIKP 736

  Fly   486 TSCYTG-------SIIAFVTLPAFPDTVDSVL-------DLLGLF----------FRVGTLNNGG 526
            ..|:||       :|.....|..:...:.:|:       :|.|:.          ||.||:....
Human   737 PKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESS 801

  Fly   527 WETWFQNSTHIPTSRLYKKMEFVGSVDEGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFSDENISR 591
            .|.:.:.|  .|....|.:...|.:..:|:..:........||:..||.|:|.|.
Human   802 AEDYVRQS--FPEMHEYMRRYNVPATPDGVEYLKNDPEKLDAFIMDKALLDYEVS---------- 854

  Fly   592 RSALHLSEEC--------FALFQIGFLFPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRS 648
                 :..:|        ||:...|...|..|.....|..:|...:..|.:..::::  |.
Human   855 -----IDADCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDK--WY---- 908

  Fly   649 SSGRLLQASSSNSLREIIQEERQLTTADTEGMFLLMALGYFLGATALVSEIVGGITNKCRQIIKR 713
               |::.....:.   .:.|..|:......|:|:|:.:|:.|.....:.|.:     ..|.::.|
Human   909 ---RVVPCGKRSF---AVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHI-----VYRLLLPR 962

  Fly   714 -SRKSAASSWSSASSGSMLRTNA----EQLSHDKRKANRREAAEVAQKMSFGMREL------NLT 767
             ..||....|...|.......|.    |:..|.|.|       .|.::.:.|.|:|      ||:
Human   963 IKNKSKLQYWLHTSQRLHRAINTSFIEEKQQHFKTK-------RVEKRSNVGPRQLTVWNTSNLS 1020

  Fly   768 RATLREIYGSYGAPETDHGQLDI-VHTEFP--------------NSSAKLNNIEDEESREALESL 817
            ....|:...|   .|....||.| :|.:.|              |..|...|:......:.|..|
Human  1021 HDNRRKYIFS---DEEGQNQLGIRIHQDIPLPPRRRELPALRTTNGKADSLNVSRNSVMQELSEL 1082

  Fly   818 QR 819
            ::
Human  1083 EK 1084

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	73/381 (19%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	51/289 (18%)
GRIN3A	NP_597702.2	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	36/226 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	59..118
		ANF_receptor	127..469	CDD:279440	29/198 (15%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	83/467 (18%)
		Lig_chan	676..942	CDD:278489	56/316 (18%)
		PPP2CB binding site. /evidence=ECO:0000250	951..987		8/40 (20%)
		GIT1-binding. /evidence=ECO:0000250\|UniProtKB:Q9R1M7	1062..1095		5/23 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810