DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir21a and Grik4

DIOPT Version :9

Sequence 1:	NP_001097043.1	Gene:	Ir21a / 33157	FlyBaseID:	FBgn0031209	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_780690.2	Gene:	Grik4 / 110637	MGIID:	95817	Length:	956	Species:	Mus musculus

Alignment Length:	904	Identity:	179/904 - (19%)
Similarity:	307/904 - (33%)	Gaps:	324/904 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 RLINHYQLNKEIFGVGMCDGNNE-----NEFRQKRRIVPTFQGNPRPRGELLASKFH-------- 85
            :|:..:.::|:...|.|.|...:     .|.|..:........|        ||..|
Mouse   177 KLLRQFLISKDTLSVRMLDDTRDPTPLLKEIRDDKTATIIIHAN--------ASMSHTILLKAAE 233

  Fly    86 ---VNSY----------NFEQTNSLV---------GLVNK-----------IAQEYLNKCPPVIY 117
               |::|          :.::.:|||         .:.|:           :.|.:...|..|.:
Mouse   234 LGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFSQSLNQSWQENCDHVPF 298

  Fly   118 YDSFVEKSDGLILENLFKTI---------------PIT------FYHGEINADY--EAKNKRFTS 159
            ....:  |..|:.:.::..:               |::      :.||....:|  ..:.:..|.
Mouse   299 TGPAL--SSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLTG 361

  Fly   160 HIDCNCK----SYILFLSDPLMTRKILGPQTESRVVLVSRS-----TQWRLRDFLSSELSSNIVN 215
            ||:.|.|    :|.|                  :::..:|:     .||.:.:.||.:
Mouse   362 HIEFNSKGQRSNYAL------------------KILQFTRNGFQQIGQWHVAEGLSMD------- 401

  Fly   216 LLVIGESLMADPMRERPYVLYTHKLYADGLGS---NTPVVLTSWIKGALSRPHINLFPSKFQFGF 277
                                  .:|||..:..   ||.:|:|:    .|..|::.|
Mouse   402 ----------------------SRLYASNISDSLFNTTLVVTT----ILENPYLML--------- 431

  Fly   278 AGHRFQISAANQPPFIFRIRTLDSSGMGQLRWDGVEFRLLTMISKRLNFSIDIT-------ETPT 335
            .|:..::.                   |..|::|....:|..:::.|.|:..|.       ..|.
Mouse   432 KGNHQEME-------------------GNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPE 477

  Fly   336 RSNT-RGVVDTIQEQIIERTVDIGMSGIYITQER--LMDSAMSVGHSPDCAAFITLASKAL---- 393
            .:.| .|:|.    ::|.|..|:.::|:.||.||  ::|.:         ..|:||....|
Mouse   478 ANGTWTGMVG----ELIARKADLAVAGLTITAEREKVIDFS---------KPFMTLGISILYRVH 529

  Fly   394 ----PKYRAIMGPFQWPVWVALICVYLGGIFPIVFTDRLT-------------LSHLMGNWGEVE 441
                |.|.:.:.||...||:.::..||.....:....|||             ..:|:.|...:.
Mouse   530 MGRRPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLG 594

  Fly   442 NMFWYVFGMFTNAFSFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTGSIIAFVTLPAFPDTV 506
            |..|:..|      .|..:.|....|..|||.:.|.:|.||:||.|.||.::.||:|:......:
Mouse   595 NSLWFPVG------GFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPI 653

  Fly   507 DSVLDLLG-LFFRVGTLNNGGWETWFQNSTHIPTSRLYKKM------EFVGSVDEGIGNVTQSFF 564
            :||.||.. .....||::.|...|:||||.:....|::..|      .||.|.:|||..|..|
Mouse   654 ESVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNS-- 716

  Fly   565 WNYAFLGSKAQLEYLVQSNFSDENISRRSALHLSEECFALFQIGFL---------FPRESVYKIK 620
             |||||......||..|.|.:                  |.|||.|         .|..||::.:
Mouse   717 -NYAFLLESTMNEYYRQRNCN------------------LTQIGGLLDTKGYGIGMPVGSVFRDE 762

  Fly   621 IDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLREIIQEERQLTTADTEGMFLLMA 685
            .|..||..|:       ||.:..:.::...|       ....:|.....:.|...:..|:|:::.
Mouse   763 FDLAILQLQE-------NNRLEILKRKWWEG-------GKCPKEEDHRAKGLGMENIGGIFVVLI 813

  Fly   686 LGYFLGATALVSEIVGGITNKCRQIIKRSRKSAASSWSSASSGSMLRTNAEQLSHDKRKANRREA 750
            .|..:.....:.|.:                     |:              |.|.       ||
Mouse   814 CGLIVAIFMAMLEFL---------------------WT--------------LRHS-------EA 836

  Fly   751 AEVA--QKMSFGMRELNLTRATL---REIYGSYGAPETDHGQLDIVHTEFPNSSAKLNN 804
            :||:  |:|...:|.:.|.:..:   |...|  |.|.    |..::....|..:|.|:|
Mouse   837 SEVSVCQEMVTELRNIILCQDNIHPRRRRSG--GLPP----QPPVLEERRPRGTATLSN 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	88/331 (27%)
Ir21a	NP_001097043.1	Lig_chan	407..662	CDD:278489	76/283 (27%)
Grik4	NP_780690.2	Periplasmic_Binding_Protein_type1	24..402	CDD:385651	38/281 (14%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	111/448 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910