Protein Alignment Ir21a and Grik4

DIOPT Version :10

• Sequence 1: NP_001097043.1
• Gene: Ir21a / 33157
• FlyBaseID: FBgn0031209
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: NP_780690.2
• Gene: Grik4 / 110637
• MGIID: 95817
• Length: 956
• Species: Mus musculus
• Alignment Length: 904
• Identity: 179/904 - (19%)
• Similarity: 307/904 - (33%)
• Gaps: 324/904 - (35%)

  Fly    34 RLINHYQLNKEIFGVGMCDGNNE-----NEFRQKRRIVPTFQGNPRPRGELLASKFH-------- 85
            :|:..:.::|:...|.|.|...:     .|.|..:........|        ||..|
Mouse   177 KLLRQFLISKDTLSVRMLDDTRDPTPLLKEIRDDKTATIIIHAN--------ASMSHTILLKAAE 233

  Fly    86 ---VNSY----------NFEQTNSLV---------GLVNK-----------IAQEYLNKCPPVIY 117
               |::|          :.::.:|||         .:.|:           :.|.:...|..|.:
Mouse   234 LGMVSAYYTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFSQSLNQSWQENCDHVPF 298

  Fly   118 YDSFVEKSDGLILENLFKTI---------------PIT------FYHGEINADY--EAKNKRFTS 159
            ....:  |..|:.:.::..:               |::      :.||....:|  ..:.:..|.
Mouse   299 TGPAL--SSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLRMVELEGLTG 361

  Fly   160 HIDCNCK----SYILFLSDPLMTRKILGPQTESRVVLVSRS-----TQWRLRDFLSSELSSNIVN 215
            ||:.|.|    :|.|                  :::..:|:     .||.:.:.||.:
Mouse   362 HIEFNSKGQRSNYAL------------------KILQFTRNGFQQIGQWHVAEGLSMD------- 401

  Fly   216 LLVIGESLMADPMRERPYVLYTHKLYADGLGS---NTPVVLTSWIKGALSRPHINLFPSKFQFGF 277
                                  .:|||..:..   ||.:|:|:    .|..|::.|
Mouse   402 ----------------------SRLYASNISDSLFNTTLVVTT----ILENPYLML--------- 431

  Fly   278 AGHRFQISAANQPPFIFRIRTLDSSGMGQLRWDGVEFRLLTMISKRLNFSIDIT-------ETPT 335
            .|:..::.                   |..|::|....:|..:::.|.|:..|.       ..|.
Mouse   432 KGNHQEME-------------------GNDRYEGFCVDMLKELAEILRFNYKIRLVGDGVYGVPE 477

  Fly   336 RSNT-RGVVDTIQEQIIERTVDIGMSGIYITQER--LMDSAMSVGHSPDCAAFITLASKAL---- 393
            .:.| .|:|.    ::|.|..|:.::|:.||.||  ::|.:         ..|:||....|
Mouse   478 ANGTWTGMVG----ELIARKADLAVAGLTITAEREKVIDFS---------KPFMTLGISILYRVH 529

  Fly   394 ----PKYRAIMGPFQWPVWVALICVYLGGIFPIVFTDRLT-------------LSHLMGNWGEVE 441
                |.|.:.:.||...||:.::..||.....:....|||             ..:|:.|...:.
Mouse   530 MGRRPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLG 594

  Fly   442 NMFWYVFGMFTNAFSFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTGSIIAFVTLPAFPDTV 506
            |..|:..|      .|..:.|....|..|||.:.|.:|.||:||.|.||.::.||:|:......:
Mouse   595 NSLWFPVG------GFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPI 653

  Fly   507 DSVLDLLG-LFFRVGTLNNGGWETWFQNSTHIPTSRLYKKM------EFVGSVDEGIGNVTQSFF 564
            :||.||.. .....||::.|...|:||||.:....|::..|      .||.|.:|||..|..|
Mouse   654 ESVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNS-- 716

  Fly   565 WNYAFLGSKAQLEYLVQSNFSDENISRRSALHLSEECFALFQIGFL---------FPRESVYKIK 620
             |||||......||..|.|.:                  |.|||.|         .|..||::.:
Mouse   717 -NYAFLLESTMNEYYRQRNCN------------------LTQIGGLLDTKGYGIGMPVGSVFRDE 762

  Fly   621 IDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLREIIQEERQLTTADTEGMFLLMA 685
            .|..||..|:       ||.:..:.::...|       ....:|.....:.|...:..|:|:::.
Mouse   763 FDLAILQLQE-------NNRLEILKRKWWEG-------GKCPKEEDHRAKGLGMENIGGIFVVLI 813

  Fly   686 LGYFLGATALVSEIVGGITNKCRQIIKRSRKSAASSWSSASSGSMLRTNAEQLSHDKRKANRREA 750
            .|..:.....:.|.:                     |:              |.|.       ||
Mouse   814 CGLIVAIFMAMLEFL---------------------WT--------------LRHS-------EA 836

  Fly   751 AEVA--QKMSFGMRELNLTRATL---REIYGSYGAPETDHGQLDIVHTEFPNSSAKLNN 804
            :||:  |:|...:|.:.|.:..:   |...|  |.|.    |..::....|..:|.|:|
Mouse   837 SEVSVCQEMVTELRNIILCQDNIHPRRRRSG--GLPP----QPPVLEERRPRGTATLSN 889

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	HisJ	287..>392	CDD:440596	23/114 (20%)
		Lig_chan	405..662	CDD:459656	76/285 (27%)
Grik4	NP_780690.2	Periplasmic_Binding_Protein_type1	24..402	CDD:471960	38/281 (14%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	111/448 (25%)
		QRL_CxxC_CxxC	863..927	CDD:469521	9/33 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..956