Protein Alignment Ir21a and grin2c

DIOPT Version :10

• Sequence 1: NP_001097043.1
• Gene: Ir21a / 33157
• FlyBaseID: FBgn0031209
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: XP_012808364.2
• Gene: grin2c / 100496638
• XenbaseID: XB-GENE-993386
• Length: 1189
• Species: Xenopus tropicalis
• Alignment Length: 768
• Identity: 145/768 - (18%)
• Similarity: 243/768 - (31%)
• Gaps: 237/768 - (30%)

  Fly    73 PRPRGELLASKFHVNSYNFEQTNSLVGLVNKIAQEYLNKCPPVIYYDSFVEKSDGLILENLFKTI 137
            |:|||..||                               ||.::.:.
 Frog   308 PQPRGSCLA-------------------------------PPHLHGND----------------- 324

  Fly   138 PITFYHGEINADYEAKNKRFTSHIDCNCKSYILFLSDPLMTRKILGPQTESRVVLVSRSTQWRLR 202
              |.|...:|..::.:...|      |.:.|:|   ||.|....|.|......|     .:|
 Frog   325 --TLYRHMMNTVWKHREVSF------NSQGYLL---DPSMLVITLTPHRAWEEV-----GRW--- 370

  Fly   203 DFLSSELSSNIVNLLV-------IGESLMAD-------PMRERPYVLY--THKLYADGLGSNTPV 251
                   .|.|:.:..       .|..|:.|       .:.|||:|:.  |.....|.:.:..|
 Frog   371 -------ESGIIRMKYPVWPRYGAGNQLVTDSRHLTVATLEERPFVIVESTDPATGDCIRNTVP- 427

  Fly   252 VLTSWIKGALSRPHINLFPSKFQFGFAGHRFQISAANQPPFIFRIRTLDSSG--MGQLRWDGVEF 314
                      .|...||                             ||.|||  ..:|...|...
 Frog   428 ----------CRKQSNL-----------------------------TLSSSGEPYTKLCCKGFCI 453

  Fly   315 RLLTMISKRLNFSID---ITETPTRSNTRGVVDTIQEQIIERTVDIGMSGIYITQERLMDSAMSV 376
            .:|..:::.:.||.|   :|........|||.:.:..::..|...:.:..:.|.:||......||
 Frog   454 DILKKLARTVKFSYDLYLVTNGKHGKLVRGVWNGMIGEVYYRRAHLAIGSLTINEERSEIVDFSV 518

  Fly   377 GHSPDCAAFITLASKALPKYRAIMGPFQWPVWVALICVYLGGIFPIVFTDRLTLSHLMGNWGEVE 441
            .......:.:...|.......|.:.|:...||:.:..:.|..:...||.  ......||...::.
 Frog   519 PFVETGISVLVSRSNGTVSPSAFLEPYSPAVWMMMFVMCLSVVAVTVFI--FEYFSPMGYDQDLS 581

  Fly   442 NMFWYVFGMFTNAFSFT-GKYSW-------------SNTRKNSTRLLIGAYWLFTIIITSCYTGS 492
            |      |......||| ||..|             .|.|..::::::..:..|.:|..:.||.:
 Frog   582 N------GKRLGGPSFTIGKSLWLLWALVFNNSVPIQNPRGTTSKIMVLVWAFFAVIFLASYTAN 640

  Fly   493 IIAFVTLPAFPDTVDSVLDLLGLF---------FRVGTLNNGGWETWFQNSTHIPTSRLYKKMEF 548
            :.||:....:.|||..:.|  ..|         ||.||:.||..|...:  |:.|....|.....
 Frog   641 LAAFMIQEQYIDTVSGLSD--RKFQKPQEQYPPFRFGTVPNGSTERNIR--TNYPDMHSYMVRYN 701

  Fly   549 VGSVDEGIGNVTQSFFWNYAFLGSKAQLEYLVQSNFSDENISRRSALHLSEECFALFQIGFLFPR 613
            ..||::.:.::.....  .||:...|.|.|:...:...:.::..|.     :.||....|....:
 Frog   702 QRSVEDALASLKAGKL--DAFIYDAAVLNYMAGKDEGCKLVTIGSG-----KVFATTGYGIALQK 759

  Fly   614 ESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLREIIQEERQLTTADTE 678
            .|.:|..||..:|.....|...::  |..|          |.....|...|.:..  :|...:..
 Frog   760 NSRWKRPIDLALLQFLGDGDTQRL--ETVW----------LSGICQNEKNEAVSS--KLDIDNMA 810

  Fly   679 GMF--LLMALGYFL---------------------GATALVSEIVGGITNKCRQI---------- 710
            |:|  ||:|:|..|                     |...|:. |..||.:..|.:
 Frog   811 GVFYMLLVAMGLSLLVFSWEHLVYWRMRHCMPSSCGEKGLLG-ISRGIYSCFRGVESPLQDSQFP 874

  Fly   711 ------------IKRSRKSAASSWSSASSGSMLRTNAEQLSHDKRKANRREAA 751
                        :.|..::|....||::.|..|...::.|...|:::...:||
 Frog   875 DPDVTGTPVPVNVLRVLQTARDLVSSSAVGGSLENASQALRTWKQRSESLQAA 927

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	HisJ	287..>392	CDD:440596	22/109 (20%)
		Lig_chan	405..662	CDD:459656	59/279 (21%)
grin2c	XP_012808364.2	Periplasmic_Binding_Protein_type1	30..379	CDD:471960	24/144 (17%)
		PBP2_iGluR_NMDA_Nr2	395..794	CDD:270436	92/469 (20%)
		NMDAR2_C	831..>906	CDD:463148	11/75 (15%)