Protein Alignment Ir21a and grin2b

DIOPT Version :10

• Sequence 1: NP_001097043.1
• Gene: Ir21a / 33157
• FlyBaseID: FBgn0031209
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: XP_017948700.2
• Gene: grin2b / 100490580
• XenbaseID: XB-GENE-949327
• Length: 1449
• Species: Xenopus tropicalis
• Alignment Length: 834
• Identity: 146/834 - (17%)
• Similarity: 278/834 - (33%)
• Gaps: 206/834 - (24%)

  Fly    88 SYNFEQTNSLVGLVNKIAQEYLNKCPPVIYYDSFVEKSDGLILENLFKTIPITFYHGEINADYEA 152
            :|.||..:| |||.   ...|....|.::..|:              .|:|..|..|.|:..|:.
 Frog   233 TYIFEVAHS-VGLT---GYGYTWIVPSLVAGDT--------------DTVPAEFPTGLISVSYDE 279

  Fly   153 KNKRFTSHIDCNCKSYILFLSDPLMTRKILGPQTESRVVLVSRSTQWRLRDFLSSELSSNIVNLL 217
            .:....:.:.... :.|...:..:::.....||::|....:..|     |.:.:..|...::|:.
 Frog   280 WDYDLPARVRDGI-AIITTAASTMLSEHNSIPQSKSSCYNIQES-----RVYEAHMLKRYLINVT 338

  Fly   218 VIGESL--MADPMRERP---YVLYTHKLYADGLGS----NTPVVLTSWIKGALSRPHINLFPSKF 273
            ..|.:|  ..|..:..|   .:|...:...:.:|.    :..:....|       |...|:|:..
 Frog   339 FEGRNLSFSEDGYQMHPKLVIILLNQQRKWERVGKYKDRSLKMKYYVW-------PVFELYPNSE 396

  Fly   274 QFGFAGHR---FQISAANQPPFIF--------------------RIRTLDSSGMG----QLRWDG 311
            :     |:   ..|....:.||:.                    :|||.:.:..|    :....|
 Frog   397 E-----HKDEHLSIVTLEEAPFVIVEDVDPLSGTCMRNTVPCRKQIRTENRTEEGGNYIKRCCKG 456

  Fly   312 VEFRLLTMISKRLNFSID---ITETPTRSNTRGVVDTIQEQIIERTVDIGMSGIYITQERLMDSA 373
            ....:|..|:|.:.|:.|   :|.........|..:.:..:::.:...:.:..:.|.:||.....
 Frog   457 FCIDILKKIAKTVKFTYDLYLVTNGKHGKKINGTWNGMIGEVVTKRAYMAVGSLTINEERSEVVD 521

  Fly   374 MSVGHSPDCAAFITLASKALPKYRAIMGPFQWPVW----VALICVYLGGIFPIVFTDRLTLSHLM 434
            .||.......:.:...|.......|.:.||...||    |.|:.|....:|...:...:..:..:
 Frog   522 FSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCL 586

  Fly   435 GNWGE-------VENMFWYVFGMFTNAFSFTGKYSWSNTRKNSTRLLIGAYWLFTIIITSCYTGS 492
            .:..|       :....|.::|:.     |.......|.:..::::::..:..|.:|..:.||.:
 Frog   587 ADGREPGGPSFTIGKAIWLLWGLV-----FNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTAN 646

  Fly   493 IIAFVTLPAFPDTVDSVLDL-------LGLFFRVGTLNNGGWETWFQNSTHIPTSRLYKKMEFVG 550
            :.||:....:.|.|..:.|.       ....||.||:.||..|...:|:.....|.:.|..:  .
 Frog   647 LAAFMIQEEYVDQVSGLSDKKFQRPNDFSPAFRFGTVPNGSTERNIRNNYLEMHSYMVKFNQ--R 709

  Fly   551 SVDEGI-----GNVTQSFFWNYAFLGSKAQLEYLVQSNFSDENISRRSALHL----SEECFALFQ 606
            ||.:.:     |.:.       ||:...|.|.|:.         .|.....|    |.:.||...
 Frog   710 SVQDALLSLKTGKLD-------AFIYDAAVLNYMA---------GRDEGCKLVTIGSGKVFATTG 758

  Fly   607 IGFLFPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLREIIQEERQ 671
            .|....::|.:|.::|..||.....|.:.::  |..|          |.....|...|::..  |
 Frog   759 YGIAIQKDSGWKRQVDLAILQLFGDGEMEEL--EALW----------LTGICHNEKNEVMSS--Q 809

  Fly   672 LTTADTEGMFLLMA------------------------LGYFLGATALVSEIVGGITNKCRQIIK 712
            |...:..|:|.::|                        :|...|...:|..|..||.:....:..
 Frog   810 LDIDNMAGVFYMLAAAMALSLITFIMEHLFFWQLRHCFMGVCSGKPGVVFSISRGIYSCIHGVPI 874

  Fly   713 RSRKSAASSWSSASSGSMLRTNAEQLSHDKRKANRREAAEVAQKMSFGMRELNLTRATLREIYGS 777
            ..|:||.:|    .|.:|..|::..|                        .|..|...:..:.|.
 Frog   875 EDRQSAMNS----PSATMNNTHSNIL------------------------RLLRTAKNMANLSGV 911

  Fly   778 YGAPETDHGQLDIVHTE------------FPNSSAKLNNIEDEESREALESLQR 819
            .|:|::   .||.:..|            |.:|..|....|:....:.:..::|
 Frog   912 NGSPQS---ALDFIRRESSVYDISEHRRSFTHSDCKSFQPEENLFSDYISEVER 962

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	HisJ	287..>392	CDD:440596	20/131 (15%)
		Lig_chan	405..662	CDD:459656	54/283 (19%)
grin2b	XP_017948700.2	PBP1_iGluR_NMDA_NR2	28..383	CDD:380601	30/173 (17%)
		PBP2_iGluR_NMDA_Nr2	400..800	CDD:270436	77/434 (18%)
		NMDAR2_C	837..1449	CDD:463148	27/157 (17%)