Protein Alignment Ir21a and grin3bb

DIOPT Version :10

• Sequence 1: NP_001097043.1
• Gene: Ir21a / 33157
• FlyBaseID: FBgn0031209
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: XP_017213803.2
• Gene: grin3bb / 100333101
• ZFINID: ZDB-GENE-131122-77
• Length: 1114
• Species: Danio rerio
• Alignment Length: 785
• Identity: 143/785 - (18%)
• Similarity: 252/785 - (32%)
• Gaps: 257/785 - (32%)

  Fly   204 FLSSELSSNIVNLLVIGESLMADPMRERPYVLYTHKLY-----ADGLGSNTPVVLTSWIKGALSR 263
            |||:.....:...:::..:|..        |..:||::     .|.:|..|.|.:.||..|.|:.
Zfish   365 FLSNTSFVGLTGPVIVQRNLSR--------VHTSHKVHIWSLRRDAVGQPTWVTVGSWEGGRLNV 421

  Fly   264 PHINLFPS----------------KFQFGF--AGHRFQISAANQPPFIFRIRTLDSSG---MGQL 307
            ....|:..                :::.||  :|.|.::....:.||:| .|.:|..|   .||.
Zfish   422 EEQGLWQGSSPRQRTEGQMGREGRRWRAGFPVSGSRLRVVTLVEHPFVF-TREVDEDGNCPAGQY 485

  Fly   308 RWD---------------------------------GVEFRLLTMISKRLNFSID---ITETPTR 336
            ..|                                 |....||..:|:.:||..|   :.:....
Zfish   486 CLDAGTNSSETLDHLYAERAQGNKSFLPPDYSKCCYGYCIDLLEKLSEDMNFEFDLYIVGDGKYG 550

  Fly   337 SNTRGVVDTIQEQIIERTVDIGMSGIYITQER--LMD-----SAMSVG---HSPDCAAFITLASK 391
            :...|....:...::....|:.::...|...|  ::|     .:.|:|   .|.|.||.|
Zfish   551 AVKGGQWTGLVGDLLSGVADMAVTSFSINSARSKVIDFTSPFFSTSLGILVRSKDTAAPI----- 610

  Fly   392 ALPKYRAIMGPFQWPVWVAL-ICVYLGGIFPIVFTDRLTLSHLMGNWGEVENMFWYVFGMF---- 451
                 .|.|.|..|.:|:.: :.:::..:|       |||.    .|..       .|||.
Zfish   611 -----GAFMWPLHWSMWMGIFVALHITALF-------LTLY----EWKS-------PFGMTPHGR 652

  Fly   452 --TNAFSFT-----------GKYSWSNTRKNST-RLLIGAYWLFTIIITSCYTGSIIAFV----T 498
              ...||::           |:...|.|.|..| |.|:..:.:|.:::.|.||.::.|.:    |
Zfish   653 NRVKVFSYSSALNLCYAILFGRTVSSKTPKCWTGRFLMNLWAIFCLLVLSSYTANLAAVMVGEKT 717

  Fly   499 LPAFPDTVDSVLDLLGLFFRVGTLNNGGWETWFQNSTHIPTSRLYKKMEFVGSVDEGIGNVTQSF 563
            ........|:.|......||.||:.....|.:.:.|  .|....|.:.....:..:|:..:....
Zfish   718 FEEVSGIHDAKLHHPSQGFRFGTVRESSAEDYMKKS--FPEMHEYMRKFNEPTTPDGVATLKTDP 780

  Fly   564 FWNYAFLGSKAQLEYLVQSNFSDENISRRSALHLSEEC--------FALFQIGFLFPRESVYKIK 620
            ....||:..||.|:|.|.               :..:|        ||:...|...|:.|.....
Zfish   781 PQLDAFIMDKALLDYEVS---------------IDADCKLLTVGKPFAIEGYGIGLPQNSPLTSN 830

  Fly   621 IDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNSLREIIQEERQLTTADTEGMFLLMA 685
            |...:...:..|.:..::::  |........|:.          .:.|..|:......|:|:|:.
Zfish   831 ISEFVSRYKSDGYMDMLHDK--WYKVVPCGKRVF----------AVTETLQMGIRHFSGLFVLLC 883

  Fly   686 LG-----------------------------YFLGATALVSEIVGGITNKCRQIIKRSRKSAASS 721
            :|                             |:|.    .|:.:....|...:.:||.|.:...|
Zfish   884 VGVTGALLTLAGEHAFYRLVLPHIRRKQKFKYWLH----TSQKIHRALNMTYEDVKRQRANTEKS 944

  Fly   722 WS-----------SASSGSMLRTNAEQLSHDKRKANRREAAEVAQ------KMSFGMRELNLTRA 769
            .:           .|..||..|.|             .|:|:|||      ::.|.:..||..|.
Zfish   945 CNIQKAQPHPPPQPAPLGSFARWN-------------NESAKVAQEPKDNKRVHFNLETLNTRRL 996

  Fly   770 TLREIYGSYGAPETDHGQLDIVHTEFPNSSAKLNNI----------------EDEESREALESLQ 818
            ..|.:        :|.||.....|....:.:.|..:                .....::.||.||
Zfish   997 LPRVV--------SDGGQTSSASTLSSGAGSLLARVCENGGPVQRATSSVRSSSPSGQDELEELQ 1053

  Fly   819 -RLDE 822
             :::|
Zfish  1054 TKIEE 1058

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	HisJ	287..>392	CDD:440596	28/153 (18%)
		Lig_chan	405..662	CDD:459656	53/287 (18%)
grin3bb	XP_017213803.2	Periplasmic_Binding_Protein_type1	39..427	CDD:471960	15/69 (22%)
		PBP2_iGluR_NMDA_Nr3	457..852	CDD:270438	83/442 (19%)
		Lig_chan	618..885	CDD:459656	58/313 (19%)