Protein Alignment Ir21a and grin2ca

DIOPT Version :9

• Sequence 1: NP_001097043.1
• Gene: Ir21a / 33157
• FlyBaseID: FBgn0031209
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: NP_001352716.1
• Gene: grin2ca / 100003342
• ZFINID: ZDB-GENE-070822-3
• Length: 1400
• Species: Danio rerio
• Alignment Length: 898
• Identity: 167/898 - (18%)
• Similarity: 311/898 - (34%)
• Gaps: 226/898 - (25%)

  Fly    21 DRSASYQEKCISRRLINHYQLNKEIFGVGMCDGNNENEFRQKRRI----------VPTFQ-GNPR 74
            |.||.......:|||:.  |::.::..|.......:..|...|.:          :|:.. |||.
Zfish   211 DMSADGMNDLRARRLLQ--QIDAQVLLVYCSHDEAQYLFSMAREVGLVGPGYIWFIPSLAVGNPN 273

  Fly    75 -------PRG--ELLASKFHVNSYNFEQTNSLVGLVNKIAQEYLNKCPPVIYYDSFVEKSDGLIL 130
                   |.|  .::..::.::..|  :....|.:|.|..:.:              .|..|.|.
Zfish   274 IAPPDSFPVGLISIITDRWKMSLRN--RVRDGVAIVVKGVESF--------------RKQRGFIP 322

  Fly   131 ENLFKTI-PI------TFYHGEINADYEAKNKRFTSHIDCNCKSYILFLSDPLMTRKILGPQTES 188
            :.....: ||      |.|...:|..:|  |..|:.:.|.       :|.:|.|.
Zfish   323 DGHMDCLSPIRPASNGTLYRHMLNVSWE--NTDFSFNSDG-------YLVNPSMI---------- 368

  Fly   189 RVVLVSRSTQW-------------------RLRDFLSSELSSNIVNLLVIGESLMADPMRERPYV 234
             ::.:.|..||                   |...|| ..:|.|        ..|....:.|||:|
Zfish   369 -IITLDRGRQWDKVGNYESGILQMRYPVWPRYGTFL-EPVSDN--------RHLTVATLEERPFV 423

  Fly   235 LYTHKLYADGLGSNTPVVLTSWIKGALSRPHINLFPSKFQFGFAGHRFQISAANQPPFIFRIRTL 299
            :         :.:..||..|     .||    |..|.:.|    .::.:....:..|:.
Zfish   424 I---------VEAVDPVTGT-----CLS----NTVPCRRQ----SNKTETIVGHTEPYT------ 460

  Fly   300 DSSGMGQLRWDGVEFRLLTMISKRLNFSID---ITETPTRSNTRGVVDTIQEQIIERTVDIGMSG 361
                  :|...|....:|..:|:.:.||.|   :|........||:.:.:..::..:..|:.:..
Zfish   461 ------KLCCKGFCIDILKKLSRNIKFSYDLYLVTNGKHGKLVRGIWNGMIGEVFYKRADMAIGS 519

  Fly   362 IYITQERLMDSAMSVGHSPDCAAFITLASKALPKYRAIMGPFQWPVWVAL--ICVYLGGIFPIVF 424
            :.|.:||......||.......:.:...|.......|.:.|:...|||.:  :|:.:..:...||
Zfish   520 LTINEERSEIIDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFVF 584

  Fly   425 ---------TDRLTLSHLMGNWGEVENMFWYVFG-MFTNAFSFTGKYSWSNTRKNSTRLLIGAYW 479
                     ...::.....|....:....|.::| :|.|:...      .|.:..::::::..:.
Zfish   585 EYCSPVGYNRSLVSAKDPGGPTFTIGKSVWLLWGIVFNNSVPI------ENPKGTTSKIMVLVWA 643

  Fly   480 LFTIIITSCYTGSIIAFVTLPAFPDTVDSVLDLLGLF---------FRVGTLNNGGWETWFQNST 535
            .|.:|..:.||.::.||:....:.|||..:.|  ..|         ||.||:.||..|...:::
Zfish   644 FFAVIFLASYTANLAAFMIQEQYIDTVSGLSD--KKFQKPQDQYPPFRFGTVPNGSTERNIRSN- 705

  Fly   536 HIPTSRLYKKM--EFVGSVDEGIGNVTQSFFWNY--AFLGSKAQLEYLVQSNFSDENISRRSALH 596
                   |.:|  ..|....:|:.:...|.....  ||:...|.|.|:...:...:.::..|.
Zfish   706 -------YPEMHSHMVKYNQKGVEDALNSLKTGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSG-- 761

  Fly   597 LSEECFALFQIGFLFPRESVYKIKIDSMILLAQQSGLIAKINNEVSWVMQRSSSGRLLQASSSNS 661
               :.||....|....:||.:|..||..:|.....|...|:  :..|          |.....|.
Zfish   762 ---KVFATTGYGIALQKESRWKRPIDLALLQFLADGDTQKL--QTVW----------LTGICRNE 811

  Fly   662 LREIIQEERQLTTADTEGMF--LLMALGYFLGATA--------------------LVSEIVGGIT 704
            .:|::..  :|...:..|:|  ||:|:|..|...|                    .:..|..||.
Zfish   812 KKEVMSS--KLDIDNMAGVFYMLLVAMGLSLLVFAWEHLLYWKLRHSVRKSERLDFLLAISRGIY 874

  Fly   705 NKCRQIIKRSRK------SAASSWSSASSGSMLRTNAEQLSHDKRKANRREAAEVAQKMSFGMRE 763
            :....:....||      ...:|::.|:...||:|..:.:|..:.:.:...|.:..:..|  .|:
Zfish   875 SCFNGVEDTDRKGNMQNPDVTTSYTQANMLKMLQTAKDIVSSARVENSLDNATKTIENWS--RRD 937

  Fly   764 LNLTRATLRE-IYGSYGAPETDHGQLDIVHTEFPNSSAKLNNIEDEESREALE 815
            ....|.:|.. :.|:    :..||:|..:.:...|.|....|: |..::..||
Zfish   938 PESGRTSLPPCLIGT----DFSHGRLPCIASVTDNHSPYPQNV-DSTTQHLLE 985

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir21a	NP_001097043.1	Periplasmic_Binding_Protein_Type_2	289..583	CDD:304360	60/321 (19%)
		Lig_chan	407..662	CDD:278489	55/279 (20%)
grin2ca	NP_001352716.1	PBP1_iGluR_NMDA_NR2	38..398	CDD:107373	38/224 (17%)
		PBP2_iGluR_NMDA_Nr2	409..810	CDD:270436	88/475 (19%)
		NMDAR2_C	847..>938	CDD:313729	14/92 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900