DRSC/TRiP Functional Genomics Resources

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Protein Alignment l(2)gl and STXBP5L

DIOPT Version :9

Sequence 1:NP_001245801.1 Gene:l(2)gl / 33156 FlyBaseID:FBgn0002121 Length:1161 Species:Drosophila melanogaster
Sequence 2:NP_001335272.1 Gene:STXBP5L / 9515 HGNCID:30757 Length:1186 Species:Homo sapiens


Alignment Length:1284 Identity:301/1284 - (23%)
Similarity:488/1284 - (38%) Gaps:380/1284 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 RHRLQKDL----FAYRKTAQHGFPHKPSALAYDPVLKLMAIGTQTGALKVFGQPGVELYGQHTLL 76
            |..:|:.|    |...||.:|||||:|:|||:|||.|::||||:|||:::.|:|||:.|.||   
Human    47 REEIQETLTSEYFQICKTVRHGFPHQPTALAFDPVQKILAIGTRTGAIRILGRPGVDCYCQH--- 108

  Fly    77 NNSASELNVQLLEWVYGTGRILSLTAANQLILW---EPVGATLLPIK---------TLPFDGKLK 129
            .:.|:.|.:|.|   ...|.::|.::.:.|.||   :...|.|..:|         .|||..|  
Human   109 ESGAAVLQLQFL---INEGALVSASSDDTLHLWNLRQKRPAILHSLKFNRERITYCHLPFQSK-- 168

  Fly   130 KVSSLCCSLSKDLLWIGTEGGNIYQLDLHTFTIKEPVIYHDVVLEQVPPAYKLNPGAIESIRQLP 194
                        .|::|||.||.:.:::.:|.:...||..:..:|.   :.|.:||.:..:...|
Human   169 ------------WLYVGTERGNTHIVNIESFILSGYVIMWNKAIEL---STKTHPGPVVHLSDSP 218

  Fly   195 NSPSKLLVAYNRGLCVLWDFESASVQRAYIAPGHGQSV-GLTVNFEGSEFTWYHADGSYATWSID 258
            ....|||:.|..|..|.||.:|   :||.:...:.::: .:..:.||.:|...|:|||...|::.
Human   219 RDEGKLLIGYENGTVVFWDLKS---KRAELRVYYDEAIHSIDWHHEGKQFMCSHSDGSLTLWNLK 280

  Fly   259 NPEPPSNVNYVPYG--------PDPCKSINRL-YKGKRRSNDVIVFSGGMPRSAYGDHNC--VSV 312
            :|..|.... :|:|        .:.||.|.:: ||..:.|...|:||||:   :| |..|  .|:
Human   281 SPSRPFQTT-IPHGKSQREGRKSESCKPILKVEYKTCKNSEPFIIFSGGL---SY-DKACRRPSL 340

  Fly   313 HASDGHKV-CLDFTSKVIDFFVTFE----NNRDVAEVLVVLLEEELCAYDLTDPNICAIKAPYLH 372
            ....|..: .|:....:::|....|    |.......:|||||::|...|||..|....:.||..
Human   341 TIMHGKAITVLEMDHPIVEFLTLCETPYPNEFQEPYAVVVLLEKDLIVVDLTQSNFPIFENPYPM 405

  Fly   373 SVHASAVTCN-YLAS---EVVQSVYESILRAGDEQDIDYSNISWPITGGTLPDNLEESVEEDATK 433
            .:|.|.|||. |.|.   :::..:|...::   .:...|||..|||:||..  ||      .|..
Human   406 DIHESPVTCTAYFADCPPDLILVLYSIGVK---HKKQGYSNKEWPISGGAW--NL------GAQT 459

  Fly   434 LYEILLTGHEDGSVKFWDCTGVLLKPIYNFKTSSIFGSESDFRDDAAADMSAEQVDEGEPPFRKS 498
            ..||::|||.|||:||||.:.:.|:.:|..|||.:|              ..::|.||:.     
Human   460 YPEIIITGHADGSIKFWDASAITLQMLYKLKTSKVF--------------EKQKVGEGKQ----- 505

  Fly   499 GLFDPYSDDPRLAVKKIAFCPKTGQLIVGGTAGQIVIADF---------IDLPEKVSLKY----- 549
             ..:...:|| .|::.|.:||::....|.|.:..::|..|         :.|  :|.|:|     
Human   506 -TCEIVEEDP-FAIQMIYWCPESRIFCVSGVSAYVIIYKFSRHEITTEIVSL--EVRLQYDVEDI 566

  Fly   550 -------------ISMNLVSDR-----------DGFVWKGHDQLNVRSNLLDGEAIPTTERGVNI 590
                         :|..|.|.|           :|........|||::..:   .:|.   |...
Human   567 ITPEPETSPPFPDLSAQLPSSRSLSGSTNTVASEGVTKDSIPCLNVKTRPV---RMPP---GYQA 625

  Fly   591 SGVLQVL-----PPASITCMALEASWGLVSGGTAHGLVLFDF----------------------- 627
            ..|:|::     ||..||.:|:.:::|:|:.|..:||.:.||                       
Human   626 ELVIQLVWVDGEPPQQITSLAVSSAYGIVAFGNCNGLAVVDFIQKTVLLSMGTIDLYRSSDLYQR 690

  Fly   628 ---------------------KNFVP-----------------------------------VFHR 636
                                 .||.|                                   |...
Human   691 QPRSPRKNKQFIADNFCMRGLSNFYPDLTKRIRTSYQSLTELNDSPVPLELERCKSPTSDHVNGH 755

  Fly   637 CTLNPNDLTGAGEQLSR------------RKSFKKSLRESFRKLRKGRSTRTNQSNQVPTTLEAR 689
            ||...:....:|::||.            |..|:|:...:..::....:|..|:.|....:    
Human   756 CTSPTSQSCSSGKRLSSADVSKVNRWGPGRPPFRKAQSAACMEISLPVTTEENRENSYNRS---- 816

  Fly   690 PVERQIEARCADDGLGSMVRCLLFAKTYV-TNVNITSPTLWSATNASTVSVFLLHLPPAQ----- 748
               |.......|......:..|.|..::. .|.:..||.|:..|:...|.:..|:||.|.     
Human   817 ---RSSSISSIDKDSKEAITALYFMDSFARKNDSTISPCLFVGTSLGMVLIISLNLPLADEQRFT 878

  Fly   749 TAATAVPSASGNAPPHMPRRISAQLAKEIQLKHRAPVVGISIFDQAGSPV--------DQLNAGE 805
            .....:||.:                   .|..:..|:..|..|:.|..:        |..|..|
Human   879 EPVMVLPSGT-------------------FLSLKGAVLTFSCMDRMGGLMQPPYEVWRDPNNIDE 924

  Fly   806 NGSPPHR------------------VLIASEEQFKVFSLPQLKPINKYKLTANEGARIRRIHFGS 852
            |.....|                  .:|.||:|.||||||.                        
Human   925 NEKSWRRKVVMNSSSASQEIGDHQYTIICSEKQAKVFSLPS------------------------ 965

  Fly   853 FSCRISPETLQSMHGCSPTKSTRSHGDGEADPNISGSLAVSRGDVY---NETALICLTNMGDIMV 914
                   :|...:|                  ||:.:..:.:.:|.   :...|.|....|.||:
Human   966 -------QTCLYVH------------------NITETSFILQANVVVMCSSACLACFCANGHIMI 1005

  Fly   915 LSVPELKRQLNAAAVRREDINGVSSLCFTNSGEALYMMSSSELQRIALATSRVVQPTGVVPVEPL 979
            :|:|.|:..|:...:...|:....:.||||.|:|||::|.:|:||:..:.            |..
Human  1006 MSLPSLRPMLDVNYLPLTDMRIARTFCFTNEGQALYLVSPTEIQRLTYSQ------------EMC 1058

  Fly   980 ENEESVLEENDAENNKETYACDEVVNTYEIKNPSGISICTRPAEENVGRNSVQQVNGVNISNSPN 1044
            :|.:.:|  .|.....||   .|..|...:|...|.|..|...||..|..|..:.:.....:.|.
Human  1059 DNLQDML--GDLFTPIET---PEAQNRGFLKGLFGGSGQTFDREELFGEASAGKASRSLAQHIPG 1118

  Fly  1045 QAN-ETISSSIGDITVDSVRDHLNMTTTTLCSINTEETIGRLSVLSTQT 1092
            ..: |.:..:.|.:          |...|...|..:|...||..|..:|
Human  1119 PGSIEGMKGAAGGV----------MGELTRARIALDERGQRLGELEEKT 1157

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)glNP_001245801.1 WD40 repeat 39..78 CDD:293791 21/38 (55%)
WD40 repeat 84..126 CDD:293791 13/53 (25%)
WD40 repeat 131..174 CDD:293791 9/42 (21%)
WD40 repeat 188..224 CDD:293791 12/35 (34%)
LLGL 268..>338 CDD:285555 21/85 (25%)
STXBP5LNP_001335272.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 15..40
WD40 74..>281 CDD:421866 70/232 (30%)
WD 1 74..107 19/32 (59%)
WD40 repeat 74..107 CDD:293791 19/32 (59%)
WD 2 114..153 10/41 (24%)
WD40 repeat 115..153 CDD:293791 10/40 (25%)
WD 3 158..194 11/49 (22%)
WD40 repeat 211..248 CDD:293791 12/39 (31%)
WD 4 213..247 12/36 (33%)
WD40 249..>552 CDD:225201 94/339 (28%)
WD 5 253..285 9/31 (29%)
WD40 repeat 253..279 CDD:293791 8/25 (32%)
LLGL 288..396 CDD:400597 31/112 (28%)
WD 6 307..349 14/45 (31%)
WD 7 357..391 9/33 (27%)
WD 8 413..490 30/87 (34%)
WD 9 518..629 21/118 (18%)
WD 10 643..705 9/61 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 748..771 4/22 (18%)
WD 11 832..889 14/75 (19%)
WD 12 898..969 19/101 (19%)
WD 13 974..1018 11/43 (26%)
WD 14 1032..1055 12/22 (55%)
R-SNARE_STXBP5 1119..1179 CDD:277246 10/49 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 52 1.000 Domainoid score I11495
eggNOG 1 0.900 - - E1_KOG1983
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000702
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X453
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.810

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