DRSC/TRiP Functional Genomics Resources

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Protein Alignment l(2)gl and STXBP5L

DIOPT Version :10

Sequence 1:NP_523439.2 Gene:l(2)gl / 33156 FlyBaseID:FBgn0002121 Length:1161 Species:Drosophila melanogaster
Sequence 2:NP_055795.1 Gene:STXBP5L / 9515 HGNCID:30757 Length:1186 Species:Homo sapiens


Alignment Length:1284 Identity:301/1284 - (23%)
Similarity:488/1284 - (38%) Gaps:380/1284 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 RHRLQKDL----FAYRKTAQHGFPHKPSALAYDPVLKLMAIGTQTGALKVFGQPGVELYGQHTLL 76
            |..:|:.|    |...||.:|||||:|:|||:|||.|::||||:|||:::.|:|||:.|.||   
Human    47 REEIQETLTSEYFQICKTVRHGFPHQPTALAFDPVQKILAIGTRTGAIRILGRPGVDCYCQH--- 108

  Fly    77 NNSASELNVQLLEWVYGTGRILSLTAANQLILW---EPVGATLLPIK---------TLPFDGKLK 129
            .:.|:.|.:|.|   ...|.::|.::.:.|.||   :...|.|..:|         .|||..|  
Human   109 ESGAAVLQLQFL---INEGALVSASSDDTLHLWNLRQKRPAILHSLKFNRERITYCHLPFQSK-- 168

  Fly   130 KVSSLCCSLSKDLLWIGTEGGNIYQLDLHTFTIKEPVIYHDVVLEQVPPAYKLNPGAIESIRQLP 194
                        .|::|||.||.:.:::.:|.:...||..:..:|.   :.|.:||.:..:...|
Human   169 ------------WLYVGTERGNTHIVNIESFILSGYVIMWNKAIEL---STKTHPGPVVHLSDSP 218

  Fly   195 NSPSKLLVAYNRGLCVLWDFESASVQRAYIAPGHGQSV-GLTVNFEGSEFTWYHADGSYATWSID 258
            ....|||:.|..|..|.||.:|   :||.:...:.::: .:..:.||.:|...|:|||...|::.
Human   219 RDEGKLLIGYENGTVVFWDLKS---KRAELRVYYDEAIHSIDWHHEGKQFMCSHSDGSLTLWNLK 280

  Fly   259 NPEPPSNVNYVPYG--------PDPCKSINRL-YKGKRRSNDVIVFSGGMPRSAYGDHNC--VSV 312
            :|..|.... :|:|        .:.||.|.:: ||..:.|...|:||||:   :| |..|  .|:
Human   281 SPSRPFQTT-IPHGKSQREGRKSESCKPILKVEYKTCKNSEPFIIFSGGL---SY-DKACRRPSL 340

  Fly   313 HASDGHKV-CLDFTSKVIDFFVTFE----NNRDVAEVLVVLLEEELCAYDLTDPNICAIKAPYLH 372
            ....|..: .|:....:::|....|    |.......:|||||::|...|||..|....:.||..
Human   341 TIMHGKAITVLEMDHPIVEFLTLCETPYPNEFQEPYAVVVLLEKDLIVVDLTQSNFPIFENPYPM 405

  Fly   373 SVHASAVTCN-YLAS---EVVQSVYESILRAGDEQDIDYSNISWPITGGTLPDNLEESVEEDATK 433
            .:|.|.|||. |.|.   :::..:|...::   .:...|||..|||:||..  ||      .|..
Human   406 DIHESPVTCTAYFADCPPDLILVLYSIGVK---HKKQGYSNKEWPISGGAW--NL------GAQT 459

  Fly   434 LYEILLTGHEDGSVKFWDCTGVLLKPIYNFKTSSIFGSESDFRDDAAADMSAEQVDEGEPPFRKS 498
            ..||::|||.|||:||||.:.:.|:.:|..|||.:|              ..::|.||:.     
Human   460 YPEIIITGHADGSIKFWDASAITLQMLYKLKTSKVF--------------EKQKVGEGKQ----- 505

  Fly   499 GLFDPYSDDPRLAVKKIAFCPKTGQLIVGGTAGQIVIADF---------IDLPEKVSLKY----- 549
             ..:...:|| .|::.|.:||::....|.|.:..::|..|         :.|  :|.|:|     
Human   506 -TCEIVEEDP-FAIQMIYWCPESRIFCVSGVSAYVIIYKFSRHEITTEIVSL--EVRLQYDVEDI 566

  Fly   550 -------------ISMNLVSDR-----------DGFVWKGHDQLNVRSNLLDGEAIPTTERGVNI 590
                         :|..|.|.|           :|........|||::..:   .:|.   |...
Human   567 ITPEPETSPPFPDLSAQLPSSRSLSGSTNTVASEGVTKDSIPCLNVKTRPV---RMPP---GYQA 625

  Fly   591 SGVLQVL-----PPASITCMALEASWGLVSGGTAHGLVLFDF----------------------- 627
            ..|:|::     ||..||.:|:.:::|:|:.|..:||.:.||                       
Human   626 ELVIQLVWVDGEPPQQITSLAVSSAYGIVAFGNCNGLAVVDFIQKTVLLSMGTIDLYRSSDLYQR 690

  Fly   628 ---------------------KNFVP-----------------------------------VFHR 636
                                 .||.|                                   |...
Human   691 QPRSPRKNKQFIADNFCMRGLSNFYPDLTKRIRTSYQSLTELNDSPVPLELERCKSPTSDHVNGH 755

  Fly   637 CTLNPNDLTGAGEQLSR------------RKSFKKSLRESFRKLRKGRSTRTNQSNQVPTTLEAR 689
            ||...:....:|::||.            |..|:|:...:..::....:|..|:.|....:    
Human   756 CTSPTSQSCSSGKRLSSADVSKVNRWGPGRPPFRKAQSAACMEISLPVTTEENRENSYNRS---- 816

  Fly   690 PVERQIEARCADDGLGSMVRCLLFAKTYV-TNVNITSPTLWSATNASTVSVFLLHLPPAQ----- 748
               |.......|......:..|.|..::. .|.:..||.|:..|:...|.:..|:||.|.     
Human   817 ---RSSSISSIDKDSKEAITALYFMDSFARKNDSTISPCLFVGTSLGMVLIISLNLPLADEQRFT 878

  Fly   749 TAATAVPSASGNAPPHMPRRISAQLAKEIQLKHRAPVVGISIFDQAGSPV--------DQLNAGE 805
            .....:||.:                   .|..:..|:..|..|:.|..:        |..|..|
Human   879 EPVMVLPSGT-------------------FLSLKGAVLTFSCMDRMGGLMQPPYEVWRDPNNIDE 924

  Fly   806 NGSPPHR------------------VLIASEEQFKVFSLPQLKPINKYKLTANEGARIRRIHFGS 852
            |.....|                  .:|.||:|.||||||.                        
Human   925 NEKSWRRKVVMNSSSASQEIGDHQYTIICSEKQAKVFSLPS------------------------ 965

  Fly   853 FSCRISPETLQSMHGCSPTKSTRSHGDGEADPNISGSLAVSRGDVY---NETALICLTNMGDIMV 914
                   :|...:|                  ||:.:..:.:.:|.   :...|.|....|.||:
Human   966 -------QTCLYVH------------------NITETSFILQANVVVMCSSACLACFCANGHIMI 1005

  Fly   915 LSVPELKRQLNAAAVRREDINGVSSLCFTNSGEALYMMSSSELQRIALATSRVVQPTGVVPVEPL 979
            :|:|.|:..|:...:...|:....:.||||.|:|||::|.:|:||:..:.            |..
Human  1006 MSLPSLRPMLDVNYLPLTDMRIARTFCFTNEGQALYLVSPTEIQRLTYSQ------------EMC 1058

  Fly   980 ENEESVLEENDAENNKETYACDEVVNTYEIKNPSGISICTRPAEENVGRNSVQQVNGVNISNSPN 1044
            :|.:.:|  .|.....||   .|..|...:|...|.|..|...||..|..|..:.:.....:.|.
Human  1059 DNLQDML--GDLFTPIET---PEAQNRGFLKGLFGGSGQTFDREELFGEASAGKASRSLAQHIPG 1118

  Fly  1045 QAN-ETISSSIGDITVDSVRDHLNMTTTTLCSINTEETIGRLSVLSTQT 1092
            ..: |.:..:.|.:          |...|...|..:|...||..|..:|
Human  1119 PGSIEGMKGAAGGV----------MGELTRARIALDERGQRLGELEEKT 1157

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)glNP_523439.2 WD40 repeat 39..78 CDD:293791 21/38 (55%)
WD40 repeat 84..126 CDD:293791 13/53 (25%)
WD40 repeat 131..174 CDD:293791 9/42 (21%)
WD40 repeat 188..224 CDD:293791 12/35 (34%)
LLGL 268..>338 CDD:462446 21/85 (25%)
STXBP5LNP_055795.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 15..40
WD40 37..>295 CDD:441893 86/274 (31%)
WD 1 74..107 19/32 (59%)
WD40 repeat 74..107 CDD:293791 19/32 (59%)
WD 2 114..153 10/41 (24%)
WD40 repeat 115..153 CDD:293791 10/40 (25%)
WD 3 158..194 11/49 (22%)
WD40 repeat 211..248 CDD:293791 12/39 (31%)
WD 4 213..247 12/36 (33%)
WD 5 253..285 9/31 (29%)
WD40 repeat 253..279 CDD:293791 8/25 (32%)
LLGL 288..397 CDD:462446 32/113 (28%)
WD 6 307..349 14/45 (31%)
WD 7 357..391 9/33 (27%)
WD 8 413..490 30/87 (34%)
WD 9 518..629 21/118 (18%)
WD 10 643..705 9/61 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 748..771 4/22 (18%)
WD 11 832..889 14/75 (19%)
WD 12 898..969 19/101 (19%)
WD 13 974..1018 11/43 (26%)
WD 14 1032..1055 12/22 (55%)
R-SNARE_STXBP5 1119..1179 CDD:277246 10/49 (20%)
Blue background indicates that the domain is not in the aligned region.

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