Protein Alignment l(2)gl and SRO7

DIOPT Version :10

• Sequence 1: NP_523439.2
• Gene: l(2)gl / 33156
• FlyBaseID: FBgn0002121
• Length: 1161
• Species: Drosophila melanogaster
• Sequence 2: NP_015357.1
• Gene: SRO7 / 856144
• SGDID: S000006236
• Length: 1033
• Species: Saccharomyces cerevisiae
• Alignment Length: 1136
• Identity: 206/1136 - (18%)
• Similarity: 394/1136 - (34%)
• Gaps: 374/1136 - (32%)

  Fly    23 LFAYRKTAQHGFPHKPSALAYDPVLKLMAIGTQTGALKVFGQPGVELYGQHTLLNNSASELNVQL 87
            :|:..:|.::|...||.|.|:|....|:||.|.||.:.::||..||:.   ..|.:.::...::.
Yeast    65 IFSLAETNKYGMSSKPIAAAFDFTQNLLAIATVTGEVHIYGQQQVEVV---IKLEDRSAIKEMRF 126

  Fly    88 LEWVYGTGRILSLTAANQLILWEPVGATLLPIKTLPFDGKLKKVSSLCCSLSKDLLWIGTEGGN- 151
            ::.:|    ::.:.|.:.:.:.......:|....:|     .|::|:....|.|.:.||.:.|:
Yeast   127 VKGIY----LVVINAKDTVYVLSLYSQKVLTTVFVP-----GKITSIDTDASLDWMLIGLQNGSM 182

  Fly   152 -IYQLD---LHTFTIKEPVIYHDVVLEQVPPAYKLNPGAIESIRQLPNSPSKLLVAYNRGLCVLW 212
             :|.:|   |.:|.:      .::......||.:|:|  |.||:..|.....:|::|.. :.:.:
Yeast   183 IVYDIDRDQLSSFKL------DNLQKSSFFPAARLSP--IVSIQWNPRDIGTVLISYEY-VTLTY 238

  Fly   213 DFESASVQRAYI------APG--------------------HGQSVGLTVNFEGSEFTWYHADGS 251
            ......:::::|      |||                    |..|:.:....|.:...::.|:..
Yeast   239 SLVENEIKQSFIYELPPFAPGGDFSEKTNEKRTPKVIQSLYHPNSLHIITIHEDNSLVFWDANSG 303

  Fly   252 YATWS-------IDNPEPPSNVNYVPYGPDPCKSINRLY---KGKRRSNDVIVFSGGMPRSAYGD 306
            :...:       |:.|:|    :|:.........|:::|   :.......:::....:.|   ||
Yeast   304 HMIMARTVFETEINVPQP----DYIRDSSTNAAKISKVYWMCENNPEYTSLLISHKSISR---GD 361

  Fly   307 HNCVSVHASDGHKVCLDFTSKVIDFFVT--------FENNRDV------AEVLVVLLEEELCAYD 357
            :..:::       :.|.:|.:   :.:|        :.|.:.:      ..|.:|
Yeast   362 NQSLTM-------IDLGYTPR---YSITSYEGMKNYYANPKQMKIFPLPTNVPIV---------- 406

  Fly   358 LTDPNICAI--KAPYLHSVHASAVTCNYLAS-EVVQSVYESILRAGDEQDIDYSNISW--PIT-- 415
                ||..|  ::||....|...:....|.: |:...:|.|.:.. |:..:...|:||  |:.
Yeast   407 ----NILPIPRQSPYFAGCHNPGLILLILGNGEIETMLYPSGIFT-DKASLFPQNLSWLRPLATT 466

  Fly   416 --GGTLPDN-----LEESVEED-------ATKLYEI-------LLTGHEDGSVKFWDCTGVLLKP 459
              ..::|:.     |..:..:|       .||..::       .:|||.:|||:.:|
Yeast   467 SMAASVPNKLWLGALSAAQNKDYLLKGGVRTKRQKLPAEYGTAFITGHSNGSVRIYD-------- 523

  Fly   460 IYNFKTSSIFGSESDFRDDAAADMSAEQVDEGEPPFRKSGLFDPYSDDPRLAVKKIAFCPKTGQL 524
                      .|..|.:|:|:.:::..:.               .:....|||.||:|..:|.:|
Yeast   524 ----------ASHGDIQDNASFEVNLSRT---------------LNKAKELAVDKISFAAETLEL 563

  Fly   525 IVGGTAGQIVIADFIDLPEKVSLKYISMNLVSDRDGFVWKGHDQLNVRS---NLLDGEAIPTTER 586
            .|....|.:|:           .|| .:|.....:.....|..::|.|.   |..:|..:...:|
Yeast   564 AVSIETGDVVL-----------FKY-EVNQFYSVENRPESGDLEMNFRRFSLNNTNGVLVDVRDR 616

  Fly   587 GVNISGVLQVLPPASITCMALEASWGLVSG---------GTAH---GLVLFDFKNFVPVFHRCTL 639
            ..  :||.|...|::    |:.|:.|..|.         |.|:   .|:|.|.:....::..
Yeast   617 AP--TGVRQGFMPST----AVHANKGKTSAINNSNIGFVGIAYAAGSLMLIDRRGPAIIYME--- 672

  Fly   640 NPNDLTGAGEQLSRRKSFKKSLRESFRKLRKGRSTRTNQSNQVPTTLEARPVERQIEARCADDGL 704
            |..:::||                              ||..| |.:|...:|      ..|||.
Yeast   673 NIREISGA------------------------------QSACV-TCIEFVIME------YGDDGY 700

  Fly   705 GSMVRCLLFAKTYVTNVNITSPTLWSATNASTVSVFLLHLPPAQTAATAVPSASGNAPPHMPRRI 769
            .|::                   :...|:...|..:.:           :|::.|        :.
Yeast   701 SSIL-------------------MVCGTDMGEVITYKI-----------LPASGG--------KF 727

  Fly   770 SAQLAKEIQLKHRAPVVGISIFDQ-------AGSPVDQLNAGENGSPPHRVLIASEEQFKVFSLP 827
            ..||.....:..:.|:..|..|.:       |..|..| |..:....|..|||...:..::.:|.
Yeast   728 DVQLMDITNVTSKGPIHKIDAFSKETKSSCLATIPKMQ-NLSKGLCIPGIVLITGFDDIRLITLG 791

  Fly   828 QLKPIN---KYKLTANEGARIRRIHFGSFSCRISPETLQSMHGCSPTKSTRSHGDGEADPNISGS 889
            :.|..:   ||.|.|.                          |.|...:...:.|.:
Yeast   792 KSKSTHKGFKYPLAAT--------------------------GLSYISTVEKNNDRK-------- 822

  Fly   890 LAVSRGDVYNETALICLTNMGDIMVLSVPELKRQLNAAAVRREDINGVSSLCFTNSGEALYMMSS 954
                     |.|.:|.|...|.:.|.::|:.|.|::            ..:.|..:  |.|:..|
Yeast   823 ---------NLTVIITLEINGHLRVFTIPDFKEQMS------------EHIPFPIA--AKYITES 864

  Fly   955 SELQRIALATSRVVQPTGVVPVEPLENEESVLEENDAENNKETYACDEVVNTYEIKNPSGISICT 1019
            |.|:            .|.:.:...|.:.|:.     ...||......|.:|..|   :||.|..
Yeast   865 SVLR------------NGDIAIRVSEFQASLF-----STVKEQDTLAPVSDTLYI---NGIRIPY 909

  Fly  1020 RPAEENVGRNSVQQVNGVNISNSPNQANETI 1050
            ||..     ||:|...| .:..:|.|.||.:
Yeast   910 RPQV-----NSLQWARG-TVYCTPAQLNELL 934

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)gl	NP_523439.2	WD40 repeat	39..78	CDD:293791	14/38 (37%)
		WD40 repeat	84..126	CDD:293791	4/41 (10%)
		WD40 repeat	131..174	CDD:293791	10/47 (21%)
		WD40 repeat	188..224	CDD:293791	5/35 (14%)
		LLGL	268..>338	CDD:462446	9/80 (11%)
SRO7	NP_015357.1	Lgl_C	548..943	CDD:400768	108/567 (19%)