DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)gl and SRO77

DIOPT Version :9

Sequence 1:	NP_001245801.1	Gene:	l(2)gl / 33156	FlyBaseID:	FBgn0002121	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_009444.2	Gene:	SRO77 / 852168	SGDID:	S000000202	Length:	1010	Species:	Saccharomyces cerevisiae

Alignment Length:	1239	Identity:	227/1239 - (18%)
Similarity:	392/1239 - (31%)	Gaps:	461/1239 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LQKDLFAYRKTAQHGFPHKPSALAYDPVLKLMAIGTQTGALKVFGQPGVELYGQHTLLNNSASEL 83
            :....|..:|...:|...:.:...:|....|:|:.|..|.:.|:||..:|:.   ..|.|.....
Yeast    27 INSKFFDTKKICTYGINGRITVTTFDYTQSLLAVATTAGEIHVYGQKQIEVV---FTLKNRPQIK 88

  Fly    84 NVQLLEWVYGTGRILSLTAANQLILWEPVGATLLPIKTLPFDGKLKKVSSLCC---SLSKDLLWI 145
            :::.::.:|    ::::...:.:|:.......:|.....|        :|:.|   ..|.|.:.|
Yeast    89 HMRFIKGIY----LIAVDEKSNIIVLSVHSKQILTTVFCP--------NSITCIETDPSLDWMLI 141

  Fly   146 GTEGGN--IYQLDLHTFT-IKEPVIYHDVVLEQVPPAYKLNPGAIESIRQLPNSPSKLLVAYNRG 207
            |.|.|:  ||.:|.:..: :|.......|.|    |..:|:|  :.||:..|.....:|::|..
Yeast   142 GLESGSILIYDVDRNQMSKLKIENFQKSVFL----PKERLSP--VISIQWNPRDIGTILISYEH- 199

  Fly   208 LCVLWDFESASVQRAYI------APG--------------------HGQSVG-LTVNFEGSEFTW 245
            :.|::.|....|::.:.      |||                    |..|:. |||:.:.|...|
Yeast   200 ITVIYSFIDYKVKQHFFYQLEPYAPGGDLSTNIEKKRTPKVIQSLYHPNSLHILTVHEDNSLVFW 264

  Fly   246 -------YHA----------------DGSY------------------------ATWSIDNPEPP 263
                   .||                |.|:                        ||.:.:||..|
Yeast   265 DVNSGKLIHARSIFETHVNFPNPALKDCSFTETPAIFKVSWLCQRNPEYTSLLIATKATENPCLP 329

  Fly   264 SNVNYVPYGPDPCKSINRL-----YKGKRRSNDVIVFSGGMP---------RSAY----GDHNCV 310
            ..:..:..|..|..|:...     |..|.....:....|..|         .|.|    .|.|.:
Yeast   330 QEITMIDLGGTPMYSVTSFDAMSKYYAKPVQQKLFSLIGKAPLINFLPLPKASPYFGGCHDTNLI 394

  Fly   311 SVHASDGHKVCL-----DFTSKVIDFFVTFENNRDVAEVLVVLLEEELCAYDLTDPNICAIKAPY 370
            .:...||....|     .|:||...|                             |...|...|.
Yeast   395 LLLLEDGELETLIYPAGSFSSKASIF-----------------------------PRSLAWVRPT 430

  Fly   371 LHSVHASAVTCNYLASEVVQSVYESILRAGDEQDIDYSNISWPITGGTLPDNLEESVEEDATKLY 435
            :.:..|.:|..|.....:..:..||.|:.|           .|.|         .::....|:
Yeast   431 VTTCIAQSVQKNLWLGMMTIAQSESFLKGG-----------IPAT---------RNIRRHETR-- 473

  Fly   436 EILLTGHEDGSVKFWDCTGVLLKPIYNFKTSSIFGSESDFRDDAAADMSAEQVDEGEPPFRKSGL 500
            ..|||||.:|||:.||                  .|.|:..|:|..:::..:|
Yeast   474 SALLTGHSNGSVRIWD------------------ASHSEVTDNAVFEVNTAKV------------ 508

  Fly   501 FDPYSDDPRLAVKKIAFCPKTGQLIVGGTAGQIVIADFI------DLP--EKVSLKYISMNL--- 554
               .:....||:|.|:|..:|.:|.|....|.:::..|.      .||  :.:.||:...:|
Yeast   509 ---LNRATNLAIKNISFASETLELAVSSEVGDVILFKFETNKFYGQLPKSDALQLKFSRFSLDDS 570

  Fly   555 ------VSDRDGFVWKGHDQLNVRSNLLDGEAIPTT----ERGVNISGVLQVLPPASITCMALEA 609
                  ||||        ...||:...     ||:|    ::|. :|.:             :.:
Yeast   571 KTILVDVSDR--------GPTNVKQGF-----IPSTVIHAKKGA-VSAI-------------MNS 608

  Fly   610 SWGLVSGGTAHG-LVLFDFKNFVPVFHRCTLNPNDLTGAGEQLSRRKSFKKSLRESFRKLRKGRS 673
            :.|.|:.|...| |::.|.:....:|:                           |:.|.:.|..|
Yeast   609 NIGFVAVGFIEGTLIILDRRGPAIIFN---------------------------ENIRVISKAGS 646

  Fly   674 TRTNQSNQVPTTLEARPVERQIEARCADDGLGSMVRCLLFAKTYVTNVNITSPTLWSATNASTVS 738
            :..       :|:....:|      ..|||..|::                   :...|:...:.
Yeast   647 SYV-------STVHFCVME------YGDDGFSSIL-------------------MLCGTDIGELM 679

  Fly   739 VFLLHLPPAQTAATAVPSASGNAPPHMPRRISAQLAKEIQLKHRAPVVGISIFDQAGSPVDQLNA 803
            .|.:           :|:.:|        |...:.....:..::..::||:.|           |
Yeast   680 TFKI-----------LPATNG--------RFEVKFTDATKTNNQGKILGINSF-----------A 714

  Fly   804 GENGSPPHRVLIASEEQFKVFSLPQLKPINKYKLTANEGARIRRIHFGSFSCRISPETLQSMHGC 868
            .:.|......:...:...|..::|....|:    .||:   ||.:
Yeast   715 KDTGYSCSATISKMQGLSKGIAIPGFVTIS----GAND---IRLV-------------------- 752

  Fly   869 SPTKSTRSHG-----------------DGEADPNISGSLAVSRGDVYNETALICLTNMGDIMVLS 916
            ||.||..:|.                 ||:.:..:|             |.:|.|...|||.||:
Yeast   753 SPGKSKDTHALFKYPIATSGLSFIPIIDGKGERKLS-------------TIMIVLLINGDIKVLT 804

  Fly   917 VPELKR--------QLNAAAVRREDI--NGVSSLCFTNSGEALYMMSSSELQRIALATSRVVQPT 971
            |||||.        .|:|..|....|  || ..:..|...:|..:   |.|...|..|:.....:
Yeast   805 VPELKEVKNLRCPVPLSAQYVENSSILENG-DIVIRTGKFQASLI---SVLNESATGTNHTADIS 865

  Fly   972 GVVPVEPLENEESVLEENDAENNKE---------TYACDEVV-------NTYEIKNPSGISI-CT 1019
            ...|::.|.|.:..:......|:.:         .|..||::       :.||   .|.|:. |.
Yeast   866 QHTPIDTLYNPDLKIGYRPQVNSLQWARGTIYCTPYQLDELLGGIERPESKYE---ESAIARGCI 927

  Fly  1020 RPAEENVGR---------------NSVQQVNGVNISNSPNQANETISSSIGDITVDSVRDHLNMT 1069
            ..:..|..|               .|..:.||..:..|.::|.||        .:|:|...:|..
Yeast   928 SSSSSNAARKLPPGTEDHRYARPVRSSGRSNGYGVLKSVSRAIET--------RLDTVETTINDY 984

  Fly  1070 TTTL 1073
            .||:
Yeast   985 ATTM 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)gl	NP_001245801.1	WD40 repeat	39..78	CDD:293791	10/38 (26%)
		WD40 repeat	84..126	CDD:293791	4/41 (10%)
		WD40 repeat	131..174	CDD:293791	13/48 (27%)
		WD40 repeat	188..224	CDD:293791	8/35 (23%)
		LLGL	268..>338	CDD:285555	18/92 (20%)
SRO77	NP_009444.2	WD40_like	<48..>151	CDD:407205	23/117 (20%)
		WD40 repeat	88..122	CDD:293791	3/37 (8%)
		WD40 repeat	127..167	CDD:293791	11/39 (28%)
		WD40 repeat	180..233	CDD:293791	11/53 (21%)
		WD40 repeat	240..264	CDD:293791	6/23 (26%)
		Lgl_C	514..916	CDD:400768	100/561 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345888
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1983
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10241
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.930