DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)gl and DAW1

DIOPT Version :9

Sequence 1:	NP_001245801.1	Gene:	l(2)gl / 33156	FlyBaseID:	FBgn0002121	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_001190926.1	Gene:	DAW1 / 829708	AraportID:	AT4G35560	Length:	1050	Species:	Arabidopsis thaliana

Alignment Length:	1194	Identity:	217/1194 - (18%)
Similarity:	420/1194 - (35%)	Gaps:	347/1194 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 RKTAQHGFPHKPSALAYDPVLKLMAIGTQTGALKVFGQPGVELYGQHTLLNNSASELNVQLLEWV 91
            |....:|.|......||||..|::|:.|:.|.:|:||:...    |..|::...|  ..:.||:|
plant    30 RIALHYGIPSGSHLFAYDPFQKILAVSTKDGRIKLFGKDQT----QALLVSEETS--TSRFLEFV 88

  Fly    92 YGTGRILSLTAANQLILWEPVGATLLPIKTLP----FDGKLKKVSSLCCSLSKDLLWIGTEGGNI 152
            ...|.:|::.:.||:.:|:      |..|.|.    |:|   :::|..........::|...||:
plant    89 QNQGILLNVNSKNQIEVWD------LDKKLLSHVHVFNG---EITSFRVMQHTPYFYVGDSSGNV 144

  Fly   153 YQLDLHTFTIKEPVIYHDVV-LEQVPPAYKLNPGAIES---------IRQLPNSPSKLLVAYNRG 207
                 ..|.|::.  .:.|: ||...|....|...||:         :.||.....::|:.::.|
plant   145 -----SVFKIEQD--SNQVIQLEYTIPYLASNGSPIEASEDTSVVSILPQLTAESKRILLVFSSG 202

  Fly   208 LCVLWDF-ESASVQRAYIAPGHGQ--------SVGLTVNFEGSEFTWYHADGSYATWSID----- 258
            ...|||. ||..:.:..:   ||.        :....|...||..:..:::|....|||.
plant   203 FIALWDIKESKPILKTGV---HGMVKQDTKKATCACWVCPSGSRVSVGYSNGDILIWSIPSKGEC 264

  Fly   259 NPEPPSNVNYVPYGPDPCKSINRLYKGKRRSNDVI--VFSGGMPRSAY---GDHNCVSV------ 312
            :||..:.:         || :|..||.::.....:  |::.|.....|   ...|.:.|
plant   265 SPESSAMI---------CK-LNLGYKSEKIPIASLKWVYAEGKASRVYVIGSSSNSLQVVLLNEQ 319

  Fly   313 ----------HASDGHKVCLDFTSKVIDFFVTFENNRDVAEVLVVLLEE-ELCAYD--------- 357
                      |.|:   .|.|....:.|   ..|.::...:.|.||.:. .:.|||
plant   320 TETRMIKLGLHVSE---PCADMEMIIAD---VNEQSKHKQDFLFVLGKSGRVYAYDDYMIEKYLI 378

  Fly   358 ----LTDPNI---CAIKAPYLHSVHASAVTC-NYLASEVVQSVYESILRAGDEQDIDYSNISWP- 413
                .:.|::   ..:|.|:..|   |::|. .:|.:.      ..:|...||   ||:.::..
plant   379 QSQSKSSPSLPKETVVKLPFSDS---SSITVGKFLTNP------SHLLNLSDE---DYAQLAKDA 431

  Fly   414 ---ITGGTLPDNLEESVE-EDATKLYEILLTGHEDGSVKFWDCTGVLLKPIYNFKTSSIFGSESD 474
               :...|:|.....|.. ...||:..:.:|||.||::..||.|       .:|....:|..|..
plant   432 VPFLPFHTVPKESSRSAHFPGFTKVKNVYITGHCDGTISVWDMT-------CSFPILVLFLKEQQ 489

  Fly   475 FRDDAAA-----------DMSAEQVDEGE------------PPFRKSGLFDPYSDDPRLA----V 512
            ...|.::           |.::..:..|:            .|:.....|.|:....:..    |
plant   490 IDQDVSSRGNAALTALHYDSNSRLLVSGDHNGMVRLYRFKPEPYLTENSFIPFQGSLKKGNNHIV 554

  Fly   513 KKIAFCPKTG------------QLIVGGTAGQIVIADFIDLPEKVSLKYISMNLVSDRDGFVWKG 565
            :.:.:...||            .|.:|...|.:.:.|.    |:.::.| :.::.||    :..|
plant   555 QSVKYIKLTGSITCIQKSQNSKHLAIGSDQGHVSLVDI----EEANVLY-TKHIASD----ICPG 610

  Fly   566 HDQLNVRSNLLDGEAIPTTERGVNISGVLQVLPPASITCMALEASWGLVSGGTAHGLVLFDFKNF 630
            ...|...|.::.|     .|:.|    ::..:..:|:  .||::..|.:.|..    ::...|.|
plant   611 IISLQFESCIVQG-----FEKNV----LVVAMRDSSV--FALDSDTGNMIGTN----MIKPKKPF 660

  Fly   631 VPVFHRCTLNPNDLTGAGEQLSRRKSFKK-SLRESFRKLRKGRSTRTNQSNQVPTTLEARPVERQ 694
            ..::.:......|.:|.|...||..:.:: |:|:                   |:.|.
plant   661 KVLYMQILDGKQDTSGNGFDTSRESTVEEISIRQ-------------------PSVLV------- 699

  Fly   695 IEARCADDGL----------GSMVRCLLFAKTYVTNVNITSPTLWSATNASTVSVF------LLH 743
                |::..:          |  |:.:|..|.:.::...::.|.:..:......||      :..
plant   700 ----CSEKAIYIYSLAHVVQG--VKKVLHKKKFSSSPICSASTFYGTSGVGLTLVFTDGTVEIRS 758

  Fly   744 LPP-AQTAATAVPSASGNAPPHMPRRISAQLAKEIQLKHRAPVVGISIFDQAGSPVDQLNAGENG 807
            ||. :|...|::...:.::|  .|..:              |.:.||             |..:|
plant   759 LPELSQLKQTSIRGFTYSSP--KPNSL--------------PEITIS-------------ASWDG 794

  Fly   808 SPPHRVLIASEEQFKVFS-LPQLKPINKYKLTANEGARIRR----IHFGSFSCRISPETLQSMHG 867
            .   .|::..:::..|.| |||.:   .::|..:.....::    .|.|..:.. ||...:||.|
plant   795 D---LVMVNGDDELIVSSVLPQKE---TFRLVESMNRVYKKDNSVCHEGIITSS-SPREKKSMFG 852

  Fly   868 -CSPTKSTRS-----HGDGEADPNISGSLAVS----RGDVYNETALICLTNMGDIMVLSVPEL-- 920
             ...|||.|:     ....|....:|...:.:    ..:|.|...:..:|.:.|...|.:.::
plant   853 SVFKTKSKRTTDTEPESSKETIEELSKIFSTANFPWNNNVENSREINTITRVEDEEELDIDDIDI 917

  Fly   921 -----KRQLNAAAVRREDINGVSSLCFTNSGEALYMMSSSELQRIALATSRVVQPTGVVPVEPLE 980
                 .:|.......:..::|:|.....|.    :.....:|:::|                 .:
plant   918 DDHHPNQQQQEKPKEQGILSGLSKQKMANR----FSNFKGKLKQMA-----------------AK 961

  Fly   981 NEESVLEENDAENNKETYACDEVVNTY--------------------EIKNPSGISICTRPAEE- 1024
            ||:||:..::....|.....|::...|                    .:|...|||:.|...|:
plant   962 NEKSVVTNDEKHEEKNGATVDQIKKKYGFTSSDEMGAAKMAQSKLQDNLKKLQGISLRTTEMEDT 1026

  Fly  1025 --NVGRNSVQQVNGVNISNSPNQA 1046
              :....:.:.:|.|..:...:::
plant  1027 AKSFSSTAKELLNAVEFNKQSSKS 1050

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)gl	NP_001245801.1	WD40 repeat	39..78	CDD:293791	13/38 (34%)
		WD40 repeat	84..126	CDD:293791	12/45 (27%)
		WD40 repeat	131..174	CDD:293791	7/43 (16%)
		WD40 repeat	188..224	CDD:293791	10/45 (22%)
		LLGL	268..>338	CDD:285555	16/90 (18%)
DAW1	NP_001190926.1	WD40	28..333	CDD:225201	74/337 (22%)
		WD40	45..>264	CDD:295369	58/243 (24%)
		WD40 repeat	124..159	CDD:293791	7/41 (17%)
		WD40 repeat	163..191	CDD:293791	6/27 (22%)
		WD40 repeat	231..276	CDD:293791	11/54 (20%)
		WD40 repeat	334..380	CDD:293791	10/48 (21%)
		WD40 repeat	453..487	CDD:293791	12/40 (30%)
		WD40	<460..529	CDD:295369	14/75 (19%)
		WD40 repeat	495..553	CDD:293791	5/57 (9%)
		Lgl_C	499..827	CDD:285762	64/418 (15%)
		WD40 repeat	566..602	CDD:293791	6/40 (15%)
		WD40 repeat	611..669	CDD:293791	12/72 (17%)
		R-SNARE_STXBP5_6	983..1042	CDD:277226	8/58 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1983
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122541at2759
OrthoFinder	1	1.000	-	-		FOG0000702
OrthoInspector	1	1.000	-	-		mtm958
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10241
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.920