DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)gl and llgl2

DIOPT Version :9

Sequence 1:	NP_001245801.1	Gene:	l(2)gl / 33156	FlyBaseID:	FBgn0002121	Length:	1161	Species:	Drosophila melanogaster
Sequence 2:	NP_997747.1	Gene:	llgl2 / 795670	ZFINID:	ZDB-GENE-030131-9877	Length:	1020	Species:	Danio rerio

Alignment Length:	1122	Identity:	380/1122 - (33%)
Similarity:	591/1122 - (52%)	Gaps:	198/1122 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LKFIRGKGQQPSADRHRLQKDLFAYRKTAQHGFPHKPSALAYDPVLKLMAIGTQTGALKVFGQPG 66
            :|..|..|.:...|:|:  :||:.:.||.:|||||:||||.:.|.|:|:||||::||:|::|.||
Zfish     1 MKRFRRHGHESQRDKHK--QDLYQFNKTVEHGFPHQPSALGFSPSLELLAIGTRSGAIKLYGAPG 63

  Fly    67 VELYGQHTLLNNSASELNVQLLEWVYGTGRILSLTAANQLILWE-----------PVGATLL--P 118
            ||..|.|.  .|:|    |..:.::.....:::|...|.|.:|.           .:|...|  |
Zfish    64 VEFMGLHD--ENAA----VTQVHFLPNQVELVTLLEDNSLHMWTLRAHNSMCELLEIGRFTLSGP 122

  Fly   119 IKTLPFDGKLKKVSSLCCSLSKDLLWIGTEGGNIYQLDLHTF-TIKEPVIYHDVVLEQVPPAY-- 180
            ...:|   .:.:|:::....|.:||.:|||||:::.:::..| .::|..|..:.|..:||..|
Zfish   123 PGAIP---SVTRVTAVLAHSSGELLLLGTEGGHVFVVEVPGFRELEENNISVEDVQNRVPEDYVG 184

  Fly   181 KLNPGAIESIRQLPNSPSKLLVAYNRGLCVLWDFESASVQRAYIAPGHGQSVGLTVNFEGSEFTW 245
            :.|..::|::.:.|.:|.::|:.|:|||.||||.:.....:.::.....:||....  :|.....
Zfish   185 RRNLESVETLHENPLNPRQVLIGYSRGLMVLWDLDRQRPVQHFLGTQQLESVWWME--DGESILS 247

  Fly   246 YHADGSYATWSI--DNPEPPSNVNYVPYGPDPCKSINRLYK-GKRRSNDVIVFSGGMPRSAYGDH 307
            .|:||||..|::  ::|:........|||..|||:|:::.: ..::....::|||||||::|||.
Zfish   248 SHSDGSYCQWTVTGEDPQTEPEKQETPYGAFPCKAISKIIQLPSKQGPPFLIFSGGMPRASYGDR 312

  Fly   308 NCVSVHASDGHKVCLDFTSKVIDFFV--TFENNRDVAEVLVVLLEEELCAYDLTDPNICAIKAPY 370
            :|:||..|..|: .|||||::|||||  ..||::.....||||:||||...||.......|:.||
Zfish   313 HCISVIHSKTHE-ALDFTSRIIDFFVIREGENHKGEPSALVVLVEEELVVVDLQTEGWPVIQTPY 376

  Fly   371 LHSVHASAVTCNYLASEVVQSVYESILRAGDEQDIDYSNISWPITGG--TLPDNLEESVEEDATK 433
            |..:|.||:||::..|.:...::|.:..||..|:..||...|||.||  ..||..:.
Zfish   377 LVPLHCSAITCSHHVSSIPLKLWERVQAAGAHQNTHYSRKPWPINGGKNLAPDPPQR-------- 433

  Fly   434 LYEILLTGHEDGSVKFWDCTGVLLKPIYNFKTSSIFGSESDFRDDAAADMSAEQVDEGE-PPFRK 497
              ::||||||||:|:|||.:||.|.|:|...|:.:|.:::|..|      :..|..||| |||||
Zfish   434 --DLLLTGHEDGTVRFWDASGVCLYPMYKLSTAGVFHTDADPND------NMNQGSEGEWPPFRK 490

  Fly   498 SGLFDPYSDDPRLAVKKIAFCPKTGQLIVGGTAGQIVIADFIDLPEKVSLKYISMNLVSDRDGFV 562
            .|.||||||||||.::||..|..:|.|.|.||||||::.:..|...:..::...::|:..::||.
Zfish   491 VGCFDPYSDDPRLGIQKIHLCKYSGYLTVAGTAGQILVLELNDEAAEQMVEATVVDLLQGQEGFR 555

  Fly   563 WKGHDQLNVRSNLLDGEAIPTTERGVNISGVLQVLPPASITCMALEASWGLVSGGTAHGLVLFDF 627
            |||..:|:||.   :....|.   |.....::|..|||.:|.:||.:.|.||..||:||..|:|:
Zfish   556 WKGQARLDVRE---EPVLFPP---GFQPFALVQCQPPAVVTAIALHSEWKLVGFGTSHGFGLYDY 614

  Fly   628 KNFVPVFHRCTLNPNDLTGAGEQLSRRKSFKKSLRESFRKLRKGR-STRTNQSN------QVPTT 685
            .....:..:|||||:|.......|||.||.|||||:|||::|:.| |.|.:.:|      ::...
Zfish   615 NQRNNIMVKCTLNPSDQMAMEGPLSRVKSIKKSLRQSFRRIRRSRVSMRKHHTNNAAKLQEINAR 679

  Fly   686 LEAR--------PVERQIEARCADDGLGSMVRCLLFAKTYVTNVNITSPTLWSATNASTVSVFLL 742
            |||.        ||:|:||||.:||....:||.|.||.|:|::.:.::|:||:.||...|..::|
Zfish   680 LEAEALQEMELAPVQRKIEARSSDDSFTGLVRTLYFADTFVSDSSHSTPSLWAGTNGGAVFAYVL 744

  Fly   743 HLPPAQTAATAVPSASGNAPPHMPRRISAQLAKEIQLKHRAPVVGISIFDQAGSPV--------D 799
            .:||.:..|         ..|     ::|..||||||.|||||||:.:.|..|:|:        |
Zfish   745 RVPPQERRA---------EDP-----VTAHAAKEIQLMHRAPVVGLVVLDGKGAPLPEPLEVAHD 795

  Fly   800 QLNAGE-NGSPPHRVLIASEEQFKVFSLPQLKPINKYKLTANEGARIRRIHFGSFSCRISPETLQ 863
            ...:.| :||  |.:|:.||||||:|:||::...:|.||||.:|:|:||:....|.
Zfish   796 LARSPEMHGS--HHLLVVSEEQFKLFTLPKVSSKSKLKLTAVDGSRVRRVGVAWFG--------- 849

  Fly   864 SMHGCSPTKSTRSHGDGEADPNISGSLAVSRGDVYNETALICLTNMGDIMVLSVPELKRQLNAAA 928
                                         ||.|...|:.|:.|||.|::.|:|:|.:|..::...
Zfish   850 -----------------------------SRTDEQLESCLVVLTNQGELHVISLPSIKMLVHYPC 885

  Fly   929 VRREDINGVSSLCFTNSGEALYMMSSSELQRIALATSRVVQPTGVV----------PVEP----- 978
            :||||::|::|..||..|:..|::|.||.:|.:|:|..||||..:|          |..|
Zfish   886 IRREDVSGIASCVFTKYGQGFYLISPSEFERFSLSTRWVVQPHCLVEPPLQMRSKSPSSPVHRDL 950

  Fly   979 -----------------------------LENEESVLEE--NDAENNKETYACDEVVNTYEIKNP 1012
                                         |.|:||||:|  ...|.::.|:          ::|
Zfish   951 PDGVPTEHRNFKGDSEGYENSARQVMEHALLNDESVLQEIQKSLEGDQTTF----------LEN- 1004

  Fly  1013 SGISICTRPAEENVGRN 1029
               ::.|:|...||..|
Zfish  1005 ---NLKTKPKAGNVLSN 1018

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)gl	NP_001245801.1	WD40 repeat	39..78	CDD:293791	20/38 (53%)
		WD40 repeat	84..126	CDD:293791	9/54 (17%)
		WD40 repeat	131..174	CDD:293791	13/43 (30%)
		WD40 repeat	188..224	CDD:293791	12/35 (34%)
		LLGL	268..>338	CDD:285555	33/72 (46%)
llgl2	NP_997747.1	WD40	<29..253	CDD:392136	71/234 (30%)
		WD40 repeat	36..72	CDD:293791	20/37 (54%)
		WD 1	36..69		18/32 (56%)
		WD 2	76..117		6/40 (15%)
		WD40 repeat	77..119	CDD:293791	5/41 (12%)
		WD40 repeat	132..176	CDD:293791	13/43 (30%)
		WD 3	132..169		11/36 (31%)
		WD40 repeat	189..228	CDD:293791	12/38 (32%)
		WD 4	193..227		11/33 (33%)
		WD40 repeat	233..273	CDD:293791	10/41 (24%)
		WD 5	233..264		9/32 (28%)
		LLGL	273..369	CDD:369834	44/96 (46%)
		WD 6	282..324		15/41 (37%)
		WD 7	332..364		15/31 (48%)
		WD 8	386..462		33/85 (39%)
		WD 9	506..581		24/80 (30%)
		WD 10	590..651		28/60 (47%)
		WD 11	710..766		22/69 (32%)
		WD 12	775..827		19/53 (36%)
		WD 13	832..884		21/89 (24%)
		WD 14	898..921		9/22 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	935..968		2/32 (6%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594294
Domainoid	1	1.000	336	1.000	Domainoid score	I1088
eggNOG	1	0.900	-	-		E1_KOG1983
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	673	1.000	Inparanoid score	I704
OMA	1	1.010	-	-		QHG48039
OrthoDB	1	1.010	-	-		D113391at33208
OrthoFinder	1	1.000	-	-		FOG0000702
OrthoInspector	1	1.000	-	-		otm26280
orthoMCL	1	0.900	-	-		OOG6_104800
Panther	1	1.100	-	-	LDO	PTHR10241
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X453
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770