DRSC/TRiP Functional Genomics Resources

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Protein Alignment l(2)gl and Stxbp5

DIOPT Version :9

Sequence 1:NP_001245801.1 Gene:l(2)gl / 33156 FlyBaseID:FBgn0002121 Length:1161 Species:Drosophila melanogaster
Sequence 2:XP_036012001.1 Gene:Stxbp5 / 78808 MGIID:1926058 Length:1180 Species:Mus musculus


Alignment Length:1182 Identity:303/1182 - (25%)
Similarity:466/1182 - (39%) Gaps:351/1182 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 QQPSADR-----HRLQKDLFAYRKTAQHGFPHKPSALAYDPVLKLMAIGTQTGALKVFGQPGVEL 69
            |.|..:|     ..||.:.|...||.:||||::|||||:|||.|::|:|||||||::||:||||.
Mouse    28 QHPPGNREPEIQETLQSEHFQLCKTVRHGFPYQPSALAFDPVQKILAVGTQTGALRLFGRPGVEC 92

  Fly    70 YGQHTLLNNSASELNVQLLEWVYGTGRILSLTAANQLILW---EPVGATLLPIK---------TL 122
            |.||   ::.|:.:.:|.|   ...|.::|..|.:.|.||   :...|.|..:|         .|
Mouse    93 YCQH---DSGAAVIQLQFL---INEGALVSALADDTLHLWNLRQKRPAVLHSLKFCRERVTFCHL 151

  Fly   123 PFDGKLKKVSSLCCSLSKDLLWIGTEGGNIYQLDLHTFTIKEPVIYHDVVLEQVPPAYKLNPGAI 187
            ||..|              .|::|||.|||:.:::.:||:...||..:..:|.   :.|.:||.:
Mouse   152 PFQSK--------------WLYVGTERGNIHIVNVESFTLSGYVIMWNKAIEL---SSKAHPGPV 199

  Fly   188 ESIRQLPNSPSKLLVAYNRGLCVLWDFESASVQRAYIAPGHGQSVGLTVNFEGSEFTWYHADGSY 252
            ..|...|....|||:.:..|..||||.:|......|.......||..  :.||.:|...|:||:.
Mouse   200 VHISDNPMDEGKLLIGFESGTVVLWDLKSKKADYRYTYDEAIHSVAW--HHEGKQFICSHSDGTL 262

  Fly   253 ATWSIDNPEPPSNVNYVPYG--------PDPCKSINRL-YKGKRRSNDVIVFSGGMPRSAYGDHN 308
            ..|::.:|..|.. ...|:|        |:|||.|.:: .|..|.....|:.|||:.....|...
Mouse   263 TIWNVRSPAKPVQ-TITPHGKQLKDGKKPEPCKPILKVELKTTRSGEPFIILSGGLSYDTVGRRP 326

  Fly   309 CVSV-HASDGHKVCLDFTSKVIDFFVTFE----NNRDVAEVLVVLLEEELCAYDLTDPNICAIKA 368
            |::| |......:.:|::  ::||....|    |:......:|||||::|...||........:.
Mouse   327 CLTVMHGKSTAVLEMDYS--IVDFLTLCETPYPNDFQEPYAVVVLLEKDLVLIDLAQNGYPIFEN 389

  Fly   369 PYLHSVHASAVT-CNYLAS---EVVQSVYESILRAGDEQDIDYSNISWPITGGTLPDNLEESVEE 429
            ||..|:|.|.|| |.|.|.   :::.::|....|   ::...||...|||.||        :...
Mouse   390 PYPLSIHESPVTCCEYFADCPVDLIPALYSVGAR---QKRQGYSKKEWPINGG--------NWGL 443

  Fly   430 DATKLYEILLTGHEDGSVKFWDCTGVLLKPIYNFKTSSIFGSESDFRDDAAADMSAEQVDEGEPP 494
            .|....||::|||.||||||||.:.:.|:.:|..|||.:| .:|..:||.   .:.:.|||    
Mouse   444 GAQSYPEIIITGHADGSVKFWDASAITLQVLYKLKTSKVF-EKSRNKDDR---QNTDIVDE---- 500

  Fly   495 FRKSGLFDPYSDDPRLAVKKIAFCPKTGQLIVGGTAGQIVIADF--------------------- 538
                   |||      |::.|::||::..|.:.|.:..::|..|                     
Mouse   501 -------DPY------AIQIISWCPESRMLCIAGVSAHVIIYRFSKQEVLTEVIPMLEVRLLYEI 552

  Fly   539 --IDLPE-----KVSLKYISMN------------LVSDRDGFVWKGHDQLNVRSNL--LDGEAIP 582
              :|.||     .:|....|.|            ..|..||          :|.|:  |..:..|
Mouse   553 NDVDTPEGEQPPPLSTPVGSSNPQPIPPQSHPSTSSSSSDG----------LRDNVPCLKVKNSP 607

  Fly   583 TTER-GVNISGVLQVL-----PPASITCMALEASWGLVSGGTAHGLVLFDFKNFVPVFHRCTLNP 641
            ..:. |.....|:|::     ||..||.:||.:|:|||..|..:|:.:.|:.....:.:..|:  
Mouse   608 LKQSPGYQTELVIQLVWVGGEPPQQITSLALNSSYGLVVFGNCNGIAMVDYLQKAVLLNLSTI-- 670

  Fly   642 NDLTGAG-----EQLSRRKSFKKS----------------LRESFRKLR---------------- 669
             :|.|:.     |..|.|||.:.|                ..||.:|||                
Mouse   671 -ELYGSNDPYRREPRSPRKSRQPSGGMLLGTPCMCGLSSLYSESVKKLRSSVITGLCDITEGTVV 734

  Fly   670 ---------KGRSTRTNQSNQ---------------------------------VPTTLEARP-- 690
                     .|.|:..|..::                                 :||.|  :|  
Mouse   735 PEDRCKSPTSGSSSPHNSDDEQKVNNFIEKVKTQSRKFSKMVANDLAKMSRKLSLPTDL--KPDL 797

  Fly   691 -VERQIEARCADDGLGSM-------VRCLLFAKTYVTNVNIT-SPTLWSATNASTVSVFLLHLPP 746
             |:....:|.....:.|:       :..|.|.:|.....:.: ||.||..|...|..|..|:|||
Mouse   798 DVKDNSFSRSRSSSVTSIDKESRETISALHFCETLTRKADSSPSPCLWVGTTVGTAFVITLNLPP 862

  Fly   747 AQTAATAVP---SASGN---------------------APPHMP---RRISAQLAKEIQLKHRAP 784
            ........|   |.||.                     :|.:.|   ..::.:..::.:||.|.|
Mouse   863 GPEQRLLQPVIVSPSGTILRLKGAILRMAFLDATGCLMSPAYEPWKEHNVAEEKDEKEKLKKRRP 927

  Fly   785 VVGISIFDQAGSPVDQLNAGENGSPPHRVLIASEEQFKVFSLPQLKPINKYKLTANEGARIRRIH 849
            |        :.||.......||    ...:|.||:|.||.|||                      
Mouse   928 V--------SVSPSSSQEISEN----QYAVICSEKQAKVMSLP---------------------- 958

  Fly   850 FGSFSCRISPETLQSMHGCSPTKSTRSHGDGEADPNISGSLAVSRGDVY---NETALICLTNMGD 911
              :.||...                         .||:.:..|.|||:.   |...|.|....|.
Mouse   959 --TQSCAYK-------------------------QNITETSFVLRGDIVALSNSVCLACFCANGH 996

  Fly   912 IMVLSVPELKRQLNAAAVRREDINGVSSLCFTNSGEALYMMSSSELQRIALATSRVVQPTGVVPV 976
            ||..|:|.|:..|:...:...::....:.||.|:|:|||::|.:|:||:..:.            
Mouse   997 IMTFSLPSLRPLLDVYYLPLTNMRIARTFCFANNGQALYLVSPTEIQRLTYSQ------------ 1049

  Fly   977 EPLENEESVLEE 988
            |..||.:.:|.|
Mouse  1050 ETCENLQEMLGE 1061

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
l(2)glNP_001245801.1 WD40 repeat 39..78 CDD:293791 25/38 (66%)
WD40 repeat 84..126 CDD:293791 14/53 (26%)
WD40 repeat 131..174 CDD:293791 11/42 (26%)
WD40 repeat 188..224 CDD:293791 11/35 (31%)
LLGL 268..>338 CDD:285555 21/83 (25%)
Stxbp5XP_036012001.1 WD40 62..280 CDD:421866 79/243 (33%)
WD40 repeat 62..95 CDD:293791 23/32 (72%)
WD40 repeat 103..141 CDD:293791 10/40 (25%)
WD40 repeat 146..192 CDD:293791 16/62 (26%)
WD40 repeat 200..236 CDD:293791 11/35 (31%)
WD40 237..>539 CDD:225201 97/338 (29%)
WD40 repeat 241..276 CDD:293791 11/37 (30%)
LLGL 276..384 CDD:400597 30/109 (28%)
R-SNARE_STXBP5 1113..1173 CDD:277246
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 51 1.000 Domainoid score I11512
eggNOG 1 0.900 - - E1_KOG1983
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000702
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X453
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.810

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