Protein Alignment l(2)gl and llgl1

DIOPT Version :10

• Sequence 1: NP_523439.2
• Gene: l(2)gl / 33156
• FlyBaseID: FBgn0002121
• Length: 1161
• Species: Drosophila melanogaster
• Sequence 2: XP_005164198.1
• Gene: llgl1 / 751760
• ZFINID: ZDB-GENE-060825-69
• Length: 1041
• Species: Danio rerio
• Alignment Length: 1119
• Identity: 421/1119 - (37%)
• Similarity: 619/1119 - (55%)
• Gaps: 157/1119 - (14%)

  Fly     1 MLKF-IRGKGQQPSADRHRLQKDLFAYRKTAQHGFPHKPSALAYDPVLKLMAIGTQTGALKVFGQ 64
            |:|| .|.:|..|  .|.::::||||:.||.:||||::||||||||.|:||||||::||:|::|.
Zfish     1 MMKFRFRRQGNDP--HREKIKQDLFAFNKTVEHGFPNQPSALAYDPKLQLMAIGTKSGAIKIYGA 63

  Fly    65 PGVELYGQHTLLNNSASELNVQLLEWVYGTGRILSLTAANQLILWEPV----GATLLPIKTLPFD 125
            ||||:.|.|   .::|:   |..:.::.|.||||||...|.:.|||.|    .:.||.:.:....
Zfish    64 PGVEMTGLH---KDTAA---VTQIHFLCGQGRILSLLDDNTIHLWEIVQRENRSHLLEVHSFNLP 122

  Fly   126 GK-------LKKVSSLCCSLSKDLLWIGTEGGNIYQLDLHTFTIKEPVIYHDVVLEQVPPAYKLN 183
            |:       ..:|:.:..:||.:||.:|||||.::.|:|.|.|:....::.|.:::.||..||..
Zfish   123 GRPGIESTSATRVTVMLLNLSCNLLALGTEGGGVHFLELPTLTLLNKSLFQDEIMQSVPEEYKCG 187

  Fly   184 P--GAIESIRQLPNSPSKLLVAYNRGLCVLWDFESASVQRAYIAPGHGQSVGLTVNFEGSEFTWY 246
            .  |.:||:::.|....|:|:.|:|||.||||..|..|...::  |..|...|.....|:.|...
Zfish   188 KSLGPVESLQEHPKDSDKILIGYSRGLVVLWDLSSRHVDNLFL--GKQQLESLVWERSGNSFVSS 250

  Fly   247 HADGSYATWSI--DNP---EPPSNVNYVPYGPDPCKSINR-LYKGKRRSNDVIVFSGGMPRSAYG 305
            |:||.|..|::  .||   :|.|:.  :||||.|||::|: |::.......:::|||||||::||
Zfish   251 HSDGGYMVWAVSSSNPCTHDPVSST--IPYGPFPCKAVNKILWRTTESGAPLVLFSGGMPRASYG 313

  Fly   306 DHNCVSVHASDGHKVCLDFTSKVIDFFVTF----ENNRDVAEVLVVLLEEELCAYDLTDPNICAI 366
            |.:|:::.....| |.|||||:|||||...    |.:.|....|||||||||...||..|....:
Zfish   314 DRHCLTILQDSSH-VTLDFTSRVIDFFTIHCTDTEKDFDEPSALVVLLEEELVVIDLQMPGWPTV 377

  Fly   367 KAPYLHSVHASAVTCNYLASEVVQSVYESILRAGDEQD--IDYSNISWPITGG--TLPDNLEESV 427
            .||||..:|:||:||:...|.|...::|.::.||.:|.  .:|.|  |||.||  ..||
Zfish   378 PAPYLAPLHSSAITCSCHISNVPPKLWERVISAGQQQCPLQNYEN--WPICGGKNLAPD------ 434

  Fly   428 EEDATKLYEILLTGHEDGSVKFWDCTGVLLKPIYNFKTSSIFGSESDFRDDAAADMSAEQVDEGE 492
                .|..|:||||||||:|:|||.:||.|||:|...|:|||.::.:..|      |..|..|.|
Zfish   435 ----PKQKELLLTGHEDGTVRFWDASGVSLKPLYKLSTASIFQTDCEHND------SLTQAGEEE 489

  Fly   493 -PPFRKSGLFDPYSDDPRLAVKKIAFCPKTGQLIVGGTAGQIVIADFIDLPEKVSLKYISMNLVS 556
             |||||.|.||||||||||.::||:.|..:|:|:|.|||||:::....|......:...:::|:.
Zfish   490 WPPFRKVGCFDPYSDDPRLGIQKISLCKYSGKLVVAGTAGQVIVMVLGDEKSDHMIDVATVDLLQ 554

  Fly   557 DRDGFVWKGHDQLNVRSNLLDGEAI--PTTERGVNISGVLQVLPPASITCMALEASWGLVSGGTA 619
            ||:||.|||||:|..:|    |..:  |    |.....::|.||||::|.:.|.|.|.|::.||:
Zfish   555 DREGFTWKGHDRLPPKS----GSVVFAP----GFQPVVLVQCLPPAAVTAVTLHAEWNLIAFGTS 611

  Fly   620 HGLVLFDFKNFVPVFHRCTLNPNDLTGAGEQLSRRKSFKKSLRESFRKLRKGR------------ 672
            ||..|||:....||..||||:|||.......|||.||.|||||:|||::||.|
Zfish   612 HGFGLFDYHRRSPVLARCTLHPNDSLAMEGPLSRVKSLKKSLRQSFRRIRKSRVSGKKRVVVNSP 676

  Fly   673 STRTNQSNQ--VPTTLEARPVERQIEARCADDGLGSMVRCLLFAKTYVTNVNITSPTLWSATNAS 735
            :::..::|.  .....|..||:|:||.|.|||.|..:||||.||.|::.:.....||:|:.||:.
Zfish   677 TSKVQEANAHLADHDAEVTPVQRRIEPRSADDSLSGVVRCLCFADTFLRDGTHHGPTMWAGTNSG 741

  Fly   736 TVSVFLLHLPPAQTAATAVPSASGNAPPHMPRRISAQLAKEIQLKHRAPVVGISIFDQAGSPVDQ 800
            :|..:.|.:|..:..:              .:.:.|.|.|||||.||||||.|::.|..|:|:.:
Zfish   742 SVYAYALDVPSQEKFS--------------EQSVEALLGKEIQLMHRAPVVSIAVLDGRGNPLPE 792

  Fly   801 -------LNAGENGSPPHRVLIASEEQFKVFSLPQLKPINKYKLTANEGARIRRIHFGSFSCRIS 858
                   |....:....|.||||||||||||.||::....|:||||:||.|:|::...:|:
Zfish   793 PYEVSRDLAKAPDMQGSHSVLIASEEQFKVFMLPKVSAKTKFKLTAHEGCRVRKVALANFT---- 853

  Fly   859 PETLQSMHGCSPTKSTRSHGDGEADPNISGSLAVSRGDVYNETALICLTNMGDIMVLSVPELKRQ 923
                                            :||..| |:|.||:||||||||.:.|||.|:.|
Zfish   854 --------------------------------SVSSED-YSENALVCLTNMGDIHMFSVPALRPQ 885

  Fly   924 LNAAAVRREDINGVSSLCFTNSGEALYMMSSSELQRIALATSRVVQPTGVVPVE-PLENEESVLE 987
            :....||:|||:|::|..||.:|:..|::|.||.:|.:|:...:.:|...|.|| |        .
Zfish   886 VRYDCVRKEDISGIASCVFTKTGQGFYLISPSEYERFSLSARVITEPLCGVDVERP--------H 942

  Fly   988 ENDAENNKETYACDEVVNTYEIKNPSGISICTRPAEENVGRNSVQQVNGVNISNSPNQANETISS 1052
            :..|.::..|....:...|::.:..|      :.||.......::.|....|.:|||.:.:....
Zfish   943 DVSAHSSSSTTLPPQANGTHKSQAES------KSAETEDLLEEMRSVLSSPILDSPNSSADITLD 1001

  Fly  1053 SIGDITVDSVRDHL 1066
            :.||:||:.|:|.|
Zfish  1002 TTGDLTVEDVKDFL 1015

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)gl	NP_523439.2	WD40 repeat	39..78	CDD:293791	24/38 (63%)
		WD40 repeat	84..126	CDD:293791	15/45 (33%)
		WD40 repeat	131..174	CDD:293791	15/42 (36%)
		WD40 repeat	188..224	CDD:293791	15/35 (43%)
		LLGL	268..>338	CDD:462446	33/74 (45%)
llgl1	XP_005164198.1	WD40 repeat	78..126	CDD:293791	16/47 (34%)
		WD40 repeat	136..172	CDD:293791	13/35 (37%)
		WD40 repeat	193..234	CDD:293791	16/42 (38%)
		LLGL	274..375	CDD:462446	46/103 (45%)